Rationalizing the use of common parameters and technological tools to follow up Mycoplasma hyopneumoniae infections in pigs.

IF 3 2区 农林科学 Q1 VETERINARY SCIENCES Porcine Health Management Pub Date : 2024-08-23 DOI:10.1186/s40813-024-00381-x
Karina Sonalio, Filip Boyen, Bert Devriendt, Ilias Chantziaras, Lisa Beuckelaere, Evelien Biebaut, Freddy Haesebrouck, Irene Santamarta, Luís Guilherme de Oliveira, Dominiek Maes
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Abstract

Background: Mycoplasma (M.) hyopneumoniae is associated with respiratory disease in pigs and is the primary agent of enzootic pneumonia. Quantification of M. hyopneumoniae-related outcome parameters can be difficult, expensive, and time-consuming, in both research and field settings. In addition to well-established methods, technological tools are becoming available to monitor various aspects of relevant animal- and environment-related features, often in real-time. Therefore, this study aimed to assess whether certain parameters, such as animal movement and body temperature using microchips (IMT), correlate with established parameters and whether the currently used parameters can be rationalized.

Results: The percentage of movement was significantly reduced by M. hyopneumoniae infection in pigs (p < 0.05), where the M. hyopneumoniae-infected group showed a lower percentage of movement (1.9%) when compared to the negative control group (6.9%). On the other hand, macroscopic (MLCL) and microscopic (MLL) lung lesions, respiratory disease score (RDS), M. hyopneumoniae-DNA load, and anti-M. hyopneumoniae antibody levels increased significantly in the M. hyopneumoniae-infected group 28 days post-inoculation (p < 0.05). Moderate (r > 0.30) to very strong correlations (> 0.80) were observed between the abovementioned parameters (p < 0.05), except for IMT. A significant and moderate correlation was reported between IMT and rectal temperature (r = 0.49; p < 0.05). Last, the average daily weight gain and the percentage of air in the lung were not affected by M. hyopneumoniae infection (p > 0.05).

Conclusions: M. hyopneumoniae infection significantly reduced the movement of piglets and increased lung lesions, M. hyopneumoniae-DNA load, and anti-M. hyopneumoniae antibody levels; and, good correlations were observed between most parameters, indicating a direct relationship between them. Thus, we suggest that changes in movement might be a reliable indicator of M. hyopneumoniae infection in pigs, and that a selected group of parameters-specifically RDS, MLCL, MLL, M. hyopneumoniae-DNA load, anti-M. hyopneumoniae antibody levels, and movement-are optimal to assess M. hyopneumoniae infection under experimental conditions.

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合理使用通用参数和技术工具来跟踪猪肺炎支原体感染。
背景:猪肺炎支原体(M. hyopneumoniae)与猪的呼吸道疾病有关,是猪流行性肺炎的主要病原体。在研究和野外环境中,支原体肺炎相关结果参数的定量都很困难、昂贵且耗时。除了成熟的方法外,技术工具也逐渐可用来监测动物和环境相关特征的各个方面,通常是实时监测。因此,本研究旨在评估某些参数(如使用微芯片的动物运动和体温)是否与既定参数相关,以及目前使用的参数是否合理:结果:猪感染肺炎疫霉菌后,运动比例明显降低(p 0.30),上述参数之间的相关性非常强(> 0.80)(p 0.05):结论:猪肺炎霉菌感染会明显降低仔猪的运动能力,增加肺部病变、猪肺炎霉菌-DNA载量和抗猪肺炎霉菌抗体水平;大多数参数之间存在良好的相关性,表明它们之间存在直接关系。因此,我们认为运动变化可能是猪感染肺炎霉菌的一个可靠指标,而且选定的一组参数--特别是RDS、MLCL、MLL、肺炎霉菌-DNA载量、抗肺炎霉菌抗体水平和运动--是在实验条件下评估肺炎霉菌感染的最佳指标。
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来源期刊
Porcine Health Management
Porcine Health Management Veterinary-Food Animals
CiteScore
5.40
自引率
5.90%
发文量
49
审稿时长
14 weeks
期刊介绍: Porcine Health Management (PHM) is an open access peer-reviewed journal that aims to publish relevant, novel and revised information regarding all aspects of swine health medicine and production.
期刊最新文献
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