Cannabidiol plus krill oil supplementation improves chronic stifle osteoarthritis in dogs: A double-blind randomized controlled trial

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary journal Pub Date : 2024-08-22 DOI:10.1016/j.tvjl.2024.106227
K. Soontornvipart , P. Wongsirichatchai , A. Phongphuwanan , K. Chatdarong , S. Vimolmangkang
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Abstract

Osteoarthritis (OA) is the most common orthopedic disorder characterized by chronic inflammation and pain in dogs and cats. Cannabis spp. contains cannabidiol (CBD), a substance with pain relief and anti-inflammatory properties in different animals including dogs with OA. The use of CBD supplements has been increasingly intertwining in veterinary medicine. This study aimed to evaluate the clinical efficacy of CBD + krill oil-supplemented biscuit against canine OA. In total, 30 dogs with stifle OA were randomized and divided into the placebo, krill oil, and CBD + krill oil groups. The Canine Brief Pain Inventory questionnaire was used to evaluate the efficacy of each treatment against pain. Stifle temperature was monitored to identify degrees of stifle inflammation. Two and one dogs in the placebo group were excluded from the study due to worsening lameness and increased pain interference score (PIS) and pain severity score (PSS) at days 14 and 28, respectively.

The PIS and PSS scores of the krill oil and CBD + krill oil groups gradually and significantly improved after two weeks of treatment. The CBD + krill oil group had better PIS and PSS scores than the placebo and krill oil groups. However, there was no statistically significant difference in the PIS and PSS scores between the krill oil and CBD + krill oil groups. The stifle temperature of the three groups at different periods did not significantly differ. In conclusion, CBD + krill oil supplements are safe against canine OA. CBD can reduce pain and inflammation.

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大麻二酚加磷虾油能改善狗的慢性跗关节骨关节炎:双盲随机对照试验
骨关节炎(OA)是最常见的骨科疾病,其特征是猫狗的慢性炎症和疼痛。大麻属植物含有大麻二酚(CBD),这种物质对包括患有 OA 的狗在内的不同动物具有镇痛和消炎作用。CBD补充剂的使用已越来越多地与兽医学结合在一起。本研究旨在评估CBD+磷虾油补充饼干对犬类OA的临床疗效。共有30只患有跗关节OA的狗被随机分为安慰剂组、磷虾油组和CBD+磷虾油组。犬简易疼痛量表问卷用于评估每种疗法对疼痛的疗效。对跗关节温度进行监测,以确定跗关节炎症的程度。安慰剂组分别有两只和一只狗因跛行恶化以及第 14 天和第 28 天疼痛干扰评分 (PIS) 和疼痛严重程度评分 (PSS) 增加而被排除在研究之外。磷虾油组和 CBD + 磷虾油组的 PIS 和 PSS 评分在治疗两周后逐渐显著改善。CBD + 磷虾油组的 PIS 和 PSS 评分优于安慰剂组和磷虾油组。然而,磷虾油组和 CBD + 磷虾油组的 PIS 和 PSS 评分在统计学上没有显著差异。三组在不同时期的跗关节温度也没有显著差异。总之,CBD + 磷虾油补充剂对犬 OA 是安全的。CBD 可以减轻疼痛和炎症。
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来源期刊
Veterinary journal
Veterinary journal 农林科学-兽医学
CiteScore
4.10
自引率
4.50%
发文量
79
审稿时长
40 days
期刊介绍: The Veterinary Journal (established 1875) publishes worldwide contributions on all aspects of veterinary science and its related subjects. It provides regular book reviews and a short communications section. The journal regularly commissions topical reviews and commentaries on features of major importance. Research areas include infectious diseases, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology and oncology.
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