Repeated spaced cortical paired associative stimulation promotes additive plasticity in the human parietal-motor circuit

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-08-14 DOI:10.1016/j.clinph.2024.08.005

Elana R. Goldenkoff , Joseph A. Deluisi , Taraz G. Lee , Benjamin M. Hampstead , Stephan F. Taylor , Thad A. Polk , Michael Vesia

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Abstract

Objective

Repeated spaced sessions of repetitive transcranial magnetic stimulation (TMS) to the human primary motor cortex can lead to dose-dependent increases in motor cortical excitability. However, this has yet to be demonstrated in a defined cortical circuit. We aimed to examine the effects of repeated spaced cortical paired associative stimulation (cPAS) on excitability in the motor cortex.

Methods

cPAS was delivered to the primary motor cortex (M1) and posterior parietal cortex (PPC) with two coils. In the multi-dose condition, three sessions of cPAS were delivered 50-min apart. The single-dose condition had one session of cPAS, followed by two sessions of a control cPAS protocol. Motor-evoked potentials were evaluated before and up to 40 min after each cPAS session as a measure of cortical excitability.

Results

Compared to a single dose of cPAS, motor cortical excitability significantly increased after multi-dose cPAS. Increasing the number of cPAS sessions resulted in a cumulative, dose-dependent effect on excitability in the motor cortex, with each successive cPAS session leading to notable increases in potentiation.

Conclusion

Repeated spaced cPAS sessions summate to increase motor cortical excitability induced by single cPAS.

Significance

Repeated spaced cPAS could potentially restore abilities lost due to disorders like stroke.

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重复间隔皮层配对联想刺激促进人类顶叶运动回路的可塑性增加

目的对人类初级运动皮层进行有间隔的重复经颅磁刺激（TMS）可导致运动皮层兴奋性的剂量依赖性增加。然而，这一点尚未在确定的皮层回路中得到证实。我们旨在研究重复间隔皮质配对联想刺激（cPAS）对运动皮质兴奋性的影响。在多剂量条件下，三次cPAS注射间隔50分钟。在单剂量条件下，先进行一次 cPAS 治疗，然后进行两次对照 cPAS 方案治疗。结果与单剂量 cPAS 相比，多剂量 cPAS 后运动皮层兴奋性显著增加。增加cPAS疗程的次数会对运动皮层的兴奋性产生累积性、剂量依赖性效应，每次连续的cPAS疗程都会导致电位显著增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.