Removal of ceftriaxone and cefotaxime antibiotics from industrial wastewater via complexation with Cu(II)

IF 1.8 4区化学 Q3 CHEMISTRY, ANALYTICAL Analytical Sciences Pub Date : 2024-08-25 DOI:10.1007/s44211-024-00632-5

Doaa A. Abdel-Kader, Adel M. Kamal Eldean, Mohamed M. Abd El-Wahab, Mohamed S. Galal, Elham Y. Hashem

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Abstract

A high-performance liquid chromatographic method (HPLC) with UV detection is described for determination of ceftriaxone sodium (CFX) and cefotaxime sodium (CFM) content in pharmaceutical industrial wastewater. These methods are based on the detection of these antibiotics via the formation of chelate complexes with Cu(II). The developed Liquid Chromatographic method offers symmetric peak shape, good resolution and reasonable retention time for both drugs. The removal percentage reached about 100 and 92.1% at pH 7.2 for CFX and CFM, respectively. In UV detection, the removal of the chelating antibiotics were based on forming of chelate complexes with Cu(II) which detected at λ_{max =} 253 and 244 nm for CFX and CFM, respectively. Linearity, accuracy and precision were found to be acceptable over the concentration range of 5.99–59.86 µg mL⁻¹ for CFX and 14.33–71.63 µg mL⁻¹ for CFM. The proposed method can be used for the quality control of industrial wastewater containing CFX and CFM.

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通过与铜（II）络合去除工业废水中的头孢曲松和头孢噻肟抗生素。

介绍了一种高效液相色谱法（HPLC）和紫外检测法，用于测定制药工业废水中头孢曲松钠（CFX）和头孢噻肟钠（CFM）的含量。这些方法通过与 Cu(II) 形成螯合物来检测这些抗生素。所开发的液相色谱法对这两种药物具有对称的峰形、良好的分辨率和合理的保留时间。在 pH 值为 7.2 时，CFX 和 CFM 的去除率分别达到约 100%和 92.1%。在紫外检测中，螯合抗生素的去除是基于与 Cu(II) 形成的螯合物，CFX 和 CFM 的检测波长分别为 λmax = 253 nm 和 244 nm。结果表明，在 CFX 5.99-59.86 µg mL-1 和 CFM 14.33-71.63 µg mL-1 的浓度范围内，线性关系、准确度和精密度均可接受。该方法可用于含有 CFX 和 CFM 的工业废水的质量控制。

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来源期刊

Analytical Sciences 化学-分析化学

CiteScore

2.90

自引率

18.80%

发文量

232

审稿时长

1 months

期刊介绍： Analytical Sciences is an international journal published monthly by The Japan Society for Analytical Chemistry. The journal publishes papers on all aspects of the theory and practice of analytical sciences, including fundamental and applied, inorganic and organic, wet chemical and instrumental methods. This publication is supported in part by the Grant-in-Aid for Publication of Scientific Research Result of the Japanese Ministry of Education, Culture, Sports, Science and Technology.