Characterization of the stem cell landscape and identification of a stemness-associated prognostic signature in bladder cancer.

IF 5.3 2区 医学 Q1 ONCOLOGY Cancer Cell International Pub Date : 2024-08-24 DOI:10.1186/s12935-024-03465-4
Gaoteng Lin, Jiamei Lin, Hao Wang, Liucheng Wang, Fangfang Zhan, Liqian Wu, Liang Xue, Yang Dong, Wanqing Wei, Lin Liu
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Abstract

It is accepted that cancer stem cells (CSCs) are key to the occurrence, progression, drug resistance, and recurrence of bladder cancer (BLCA). Here, we aimed to characterize the landscapes of CSCs and investigate the biological and clinical signatures based on a prognostic model constructed by genes associated with CSCs. The malignant epithelial cells were discovered and sorted into six clusters through single cell analysis. C2 was identified as the CSCs. The signaling involved in the interactions between C2, cancer-associated fibroblasts (CAFs), and immune cells mainly consisted of MK, THBS, ANGPTL, VISFATIN, JAM, and ncWNT pathways. The CSC-like prognostic index (CSCLPI) constructed by the random survival forest was a reliable risk factor for BLCA and had a stable and powerful effect on predicting the overall survival of patients with BLCA. The level of CAFs was higher among patients with higher CSCLPI scores, suggesting that CAFs play a significant role in regulating biological characteristics. The CSCLPI-developed survival prediction nomogram has the potential to be applied clinically to predict the 1-, 2-, 3-, and 5-year overall survival of patients with BLCA. The CSCLPI can be used for prognostic prediction and drug treatment evaluation in the clinic.

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膀胱癌干细胞图谱的特征和干细胞相关预后特征的鉴定。
癌症干细胞(CSCs)是膀胱癌(BLCA)发生、发展、耐药和复发的关键,这一点已得到公认。在此,我们旨在描述癌干细胞的分布,并根据与癌干细胞相关的基因构建的预后模型研究其生物学和临床特征。我们发现了恶性上皮细胞,并通过单细胞分析将其分为六个集群。C2被确定为CSCs。C2、癌相关成纤维细胞(CAF)和免疫细胞之间的信号转导主要包括MK、THBS、ANGPTL、VISFATIN、JAM和ncWNT通路。随机生存森林构建的类干细胞预后指数(CSCLPI)是BLCA的可靠危险因素,对预测BLCA患者的总生存期具有稳定而强大的作用。在CSCLPI得分较高的患者中,CAFs的水平较高,这表明CAFs在调控生物学特征方面发挥着重要作用。CSCLPI开发的生存预测提名图有望应用于临床,预测BLCA患者的1年、2年、3年和5年总生存率。CSCLPI 可用于临床预后预测和药物治疗评估。
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来源期刊
CiteScore
10.90
自引率
1.70%
发文量
360
审稿时长
1 months
期刊介绍: Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.
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