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Annexin A1 triggers autophagy to orchestrate radioiodine resistance in thyroid cancer via upregulating HMGB1. 膜联蛋白A1通过上调HMGB1触发自噬，协调甲状腺癌的放射性碘抗性。
IF 6 2区 医学 Q1 ONCOLOGY
Cancer Cell International
Pub Date : 2026-03-23 DOI: 10.1186/s12935-026-04270-x
Xuehan Wang, Lin Guo, Min Yuan, Yiren Feng, Yao Wang, Gang Jin
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引用次数: 0
Characterization of KLK5-high epithelial cells and their interactions with the tumor microenvironment in high-grade serous ovarian cancer. 高级别浆液性卵巢癌中klk5 -高表达上皮细胞的特征及其与肿瘤微环境的相互作用
IF 6 2区 医学 Q1 ONCOLOGY
Cancer Cell International
Pub Date : 2026-03-22 DOI: 10.1186/s12935-026-04273-8
Zhe Wang, Longkun Ding, Qingwei Zhu, Qingjian Ou, Qi Wang, Ying Xie, Li Li, Xuan Liu, Chenghao Ni, Yufeng Wang, Yonghe Liu, Liting Yu, Jiahui Cai, Lu Gao
{"title":"Characterization of KLK5-high epithelial cells and their interactions with the tumor microenvironment in high-grade serous ovarian cancer.","authors":"Zhe Wang, Longkun Ding, Qingwei Zhu, Qingjian Ou, Qi Wang, Ying Xie, Li Li, Xuan Liu, Chenghao Ni, Yufeng Wang, Yonghe Liu, Liting Yu, Jiahui Cai, Lu Gao","doi":"10.1186/s12935-026-04273-8","DOIUrl":"https://doi.org/10.1186/s12935-026-04273-8","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 13-gene prognostic model developed using machine learning to predict the response to neoadjuvant chemoradiotherapy in rectal carcinoma. 使用机器学习开发了一个13基因预后模型来预测直肠癌对新辅助放化疗的反应。
IF 6 2区 医学 Q1 ONCOLOGY
Cancer Cell International
Pub Date : 2026-03-21 DOI: 10.1186/s12935-026-04256-9
Zhanhua Gao, Minghan Qiu, Zhen Yang, Xinyue Fang, Guoxing Yin, Qiaonan Zhang, Jinpu Liu, Ruxue Liu, Yayun Wang, Yuya Liu, Meng Zhang, Haiyang Zhang, Xiangqian Zheng, Hui Wang, Jie Hao, Ming Gao
{"title":"A 13-gene prognostic model developed using machine learning to predict the response to neoadjuvant chemoradiotherapy in rectal carcinoma.","authors":"Zhanhua Gao, Minghan Qiu, Zhen Yang, Xinyue Fang, Guoxing Yin, Qiaonan Zhang, Jinpu Liu, Ruxue Liu, Yayun Wang, Yuya Liu, Meng Zhang, Haiyang Zhang, Xiangqian Zheng, Hui Wang, Jie Hao, Ming Gao","doi":"10.1186/s12935-026-04256-9","DOIUrl":"https://doi.org/10.1186/s12935-026-04256-9","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1,4-dinitrosopiperazine specifically induces malignant nasopharyngeal transformation through the cytochrome P450 enzyme. 1,4-二硝基哌嗪通过细胞色素P450酶特异性诱导鼻咽恶性转化。
IF 6 2区 医学 Q1 ONCOLOGY
Cancer Cell International
Pub Date : 2026-03-20 DOI: 10.1186/s12935-026-04269-4
Yiwei Feng, Wei Xia, Pengcheng Zhao, Li Gong, Xunwei Feng, Nan Shi, Jiawei Wang, Shenghui Ke, Zhen Yin, Ketong Ji, Yongjing Lai, Jingyu Li, Xiang Bin, Xiang Yi, Guangyao He, Anzhou Tang
{"title":"1,4-dinitrosopiperazine specifically induces malignant nasopharyngeal transformation through the cytochrome P450 enzyme.","authors":"Yiwei Feng, Wei Xia, Pengcheng Zhao, Li Gong, Xunwei Feng, Nan Shi, Jiawei Wang, Shenghui Ke, Zhen Yin, Ketong Ji, Yongjing Lai, Jingyu Li, Xiang Bin, Xiang Yi, Guangyao He, Anzhou Tang","doi":"10.1186/s12935-026-04269-4","DOIUrl":"https://doi.org/10.1186/s12935-026-04269-4","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PDPK1 activates BIRC3 via NFKB1 to promote radiotherapy resistance in lung adenocarcinoma. PDPK1通过NFKB1激活BIRC3，促进肺腺癌放疗抵抗。
IF 6 2区 医学 Q1 ONCOLOGY
Cancer Cell International
Pub Date : 2026-03-20 DOI: 10.1186/s12935-026-04275-6
Huaping Shao, Kan Xu, Yi Liu
{"title":"PDPK1 activates BIRC3 via NFKB1 to promote radiotherapy resistance in lung adenocarcinoma.","authors":"Huaping Shao, Kan Xu, Yi Liu","doi":"10.1186/s12935-026-04275-6","DOIUrl":"https://doi.org/10.1186/s12935-026-04275-6","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of RBM23 induces ferroptosis in colon cancer cells via c-Myc regulation. 抑制RBM23通过调节c-Myc诱导结肠癌细胞铁下垂。
IF 6 2区 医学 Q1 ONCOLOGY
Cancer Cell International
Pub Date : 2026-03-19 DOI: 10.1186/s12935-026-04262-x
Je Joung Oh, Yu Jin Lee, Yeo Jeong Han, Jinbong Park, Woojin Kim, In-Seon Lee, Seunghoon Lee, Min Gi Jo, Ji Hoon Jung
{"title":"Inhibition of RBM23 induces ferroptosis in colon cancer cells via c-Myc regulation.","authors":"Je Joung Oh, Yu Jin Lee, Yeo Jeong Han, Jinbong Park, Woojin Kim, In-Seon Lee, Seunghoon Lee, Min Gi Jo, Ji Hoon Jung","doi":"10.1186/s12935-026-04262-x","DOIUrl":"https://doi.org/10.1186/s12935-026-04262-x","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sugen kinase 495 promotes the proliferation, migration and invasion of lung squamous cell carcinoma cells by targeting Foxo1 transcription factor. Sugen kinase 495通过靶向Foxo1转录因子促进肺鳞癌细胞的增殖、迁移和侵袭。
IF 6 2区 医学 Q1 ONCOLOGY
Cancer Cell International
Pub Date : 2026-03-18 DOI: 10.1186/s12935-026-04267-6
Yuanmei Lou, Jun Chen, Yangpeng Tang, Yingying Zhou, Chaowu Liu, Lin Mi, Hanbo Le, Zhijun Chen
{"title":"Sugen kinase 495 promotes the proliferation, migration and invasion of lung squamous cell carcinoma cells by targeting Foxo1 transcription factor.","authors":"Yuanmei Lou, Jun Chen, Yangpeng Tang, Yingying Zhou, Chaowu Liu, Lin Mi, Hanbo Le, Zhijun Chen","doi":"10.1186/s12935-026-04267-6","DOIUrl":"https://doi.org/10.1186/s12935-026-04267-6","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-omics data reveal B cell regulated immune heterogeneity of MIF signaling pathway in uveal melanoma. 多组学数据揭示葡萄膜黑色素瘤中B细胞调节的MIF信号通路的免疫异质性。
IF 6 2区 医学 Q1 ONCOLOGY
Cancer Cell International
Pub Date : 2026-03-16 DOI: 10.1186/s12935-026-04257-8
He-Yan Li, Li Dong, Yue-Ming Liu, Wen-Bin Wei
{"title":"Multi-omics data reveal B cell regulated immune heterogeneity of MIF signaling pathway in uveal melanoma.","authors":"He-Yan Li, Li Dong, Yue-Ming Liu, Wen-Bin Wei","doi":"10.1186/s12935-026-04257-8","DOIUrl":"https://doi.org/10.1186/s12935-026-04257-8","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeted radio-thermo dual sensitizer magnetic gold core-shells nanoparticles enhance radioresistant glioblastoma via promoting apoptosis and ROS generation. 靶向放射-热双增敏剂磁性金核-壳纳米颗粒通过促进细胞凋亡和活性氧生成来增强胶质母细胞瘤的放射抗性。
IF 6 2区 医学 Q1 ONCOLOGY
Cancer Cell International
Pub Date : 2026-03-13 DOI: 10.1186/s12935-026-04254-x
Sakine Shirvalilou, Samideh Khoei, Sepideh Khoee, Mohammad Reza Karimi, Bahareh Haji Ali, Elahe Sadri, Mohammad Hossein Parsaei
{"title":"Targeted radio-thermo dual sensitizer magnetic gold core-shells nanoparticles enhance radioresistant glioblastoma via promoting apoptosis and ROS generation.","authors":"Sakine Shirvalilou, Samideh Khoei, Sepideh Khoee, Mohammad Reza Karimi, Bahareh Haji Ali, Elahe Sadri, Mohammad Hossein Parsaei","doi":"10.1186/s12935-026-04254-x","DOIUrl":"https://doi.org/10.1186/s12935-026-04254-x","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a G2/M checkpoint subtype classifier for guiding precision therapy in liver hepatocellular carcinoma patients. G2/M检查点亚型分类器在肝癌患者精准治疗中的应用
IF 6 2区 医学 Q1 ONCOLOGY
Cancer Cell International
Pub Date : 2026-03-13 DOI: 10.1186/s12935-026-04237-y
Qianwen Zhou, Ganghua Zhang, Xuan Wang, Zhangyan Du, Honghua Peng, Yulong Zhang, Peiguo Cao
{"title":"Development of a G2/M checkpoint subtype classifier for guiding precision therapy in liver hepatocellular carcinoma patients.","authors":"Qianwen Zhou, Ganghua Zhang, Xuan Wang, Zhangyan Du, Honghua Peng, Yulong Zhang, Peiguo Cao","doi":"10.1186/s12935-026-04237-y","DOIUrl":"https://doi.org/10.1186/s12935-026-04237-y","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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