Clinicopathological Characteristics of Oral Squamous Cell Carcinoma at the Central Referral and Teaching Hospital in West Java, Indonesia.

IF 2.5 4区医学 Q3 ONCOLOGY Cancer Management and Research Pub Date : 2024-08-21 eCollection Date: 2024-01-01 DOI:10.2147/CMAR.S476557

Irna Sufiawati, Alamsyah Piliang, Adi Ahmad Yusuf, Tenny Setiani Dewi, Hasrayati Agustina, Yohana Azhar, Adi Idris

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Abstract

Purpose: This study aimed to investigate the clinicopathological characteristics of oral squamous cell carcinoma (OSCC) patients and analyze the relationship between the degree of differentiation and factors including age, sex, stage, and tumor location in West Java, Indonesia.

Patients and methods: A retrospective cross-sectional study was conducted at the Central Referral and Teaching Hospital in West Java, Indonesia. The data were collected by reviewing medical records with International Classification of Diseases (ICD) codes C00-C06 from 2016 to 2023. Descriptive statistics were employed to summarize the clinicopathological characteristics of OSCC patients. Chi-square, rank Spearman tests, and contingency correlation coefficients were used to analyze the relationship between the degree of differentiation and various factors, such as age, sex, stage, and tumor location of OSCC.

Results: Out of the 627 oral cancer patients, 70.49% were diagnosed with OSCC with a gender distribution of 45.7% males and 54.3% females, predominantly within the age range of 30-49 (37.2%). Most OSCC cases were stage IV (37.7%), with the tongue identified as the most common site (68.8%). A consistent trend of higher well-differentiated and moderately differentiated OSCC by age and gender was observed. Statistical analysis revealed no significant correlation between age, gender, tumor location, and the degree of OSCC differentiation (p>0.05). However, a statistically significant correlation was identified between the degree of OSCC differentiation and stage (p<0.001, r=0.460).

Conclusion: There is a correlation between the degree of differentiation of OSCC and stage, suggesting significant prognostic implications that can aid in treatment planning and outcome prediction. However, further studies are needed due to the lack of comprehensive data on risk factors and survival rates of oral cancer patients, which is essential for enhancing prevention and treatment strategies for OSCC.

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印度尼西亚西爪哇中央转诊和教学医院口腔鳞状细胞癌的临床病理特征。

目的：本研究旨在调查印度尼西亚西爪哇省口腔鳞状细胞癌（OSCC）患者的临床病理学特征，并分析分化程度与年龄、性别、分期和肿瘤位置等因素之间的关系：在印度尼西亚西爪哇的中央转诊和教学医院进行了一项回顾性横断面研究。数据是通过查阅2016年至2023年国际疾病分类（ICD）代码为C00-C06的病历收集的。研究采用描述性统计来总结OSCC患者的临床病理特征。采用Chi-square、等级Spearman检验和或然相关系数分析OSCC的分化程度与年龄、性别、分期和肿瘤位置等各种因素之间的关系：在 627 名口腔癌患者中，70.49% 被确诊为 OSCC，性别分布为男性 45.7%，女性 54.3%，年龄主要集中在 30-49 岁之间（37.2%）。大多数 OSCC 病例处于 IV 期（37.7%），舌头是最常见的部位（68.8%）。根据年龄和性别的不同，分化良好和中度分化的 OSCC 呈上升趋势。统计分析表明，年龄、性别、肿瘤部位与 OSCC 分化程度之间无明显相关性（P>0.05）。然而，OSCC 分化程度与分期之间存在统计学意义上的明显相关性（p 结论：OSCC 分化程度与分期之间存在相关性：OSCC的分化程度与分期之间存在相关性，这表明分化程度对预后有重要影响，有助于制定治疗计划和预测预后。然而，由于缺乏有关口腔癌患者风险因素和生存率的全面数据，因此还需要进一步的研究，这对加强 OSCC 的预防和治疗策略至关重要。

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来源期刊

Cancer Management and Research Medicine-Oncology

CiteScore

7.40

自引率

0.00%

发文量

448

审稿时长

16 weeks

期刊介绍： Cancer Management and Research is an international, peer reviewed, open access journal focusing on cancer research and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival, and quality of life for cancer patients. Specific topics covered in the journal include: ◦Epidemiology, detection and screening ◦Cellular research and biomarkers ◦Identification of biotargets and agents with novel mechanisms of action ◦Optimal clinical use of existing anticancer agents, including combination therapies ◦Radiation and surgery ◦Palliative care ◦Patient adherence, quality of life, satisfaction The journal welcomes submitted papers covering original research, basic science, clinical & epidemiological studies, reviews & evaluations, guidelines, expert opinion and commentary, and case series that shed novel insights on a disease or disease subtype.