Predictive value of early dynamic changes of NLR and PLR for the efficacy of immune checkpoint inhibitor in head and neck squamous cell carcinoma

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-10 DOI:10.1016/j.oooo.2024.07.014

Dong Hyun Kim MD, MS , Seo Yoon Jang MD , Bhumsuk Keam MD, PhD

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Abstract

Objective

We analyzed the predictive value of dynamic changes in neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) treated with immune checkpoint inhibitors (ICIs).

Study Design

A total of 104 patients with R/M HNSCC treated with ICIs during August 2018 to June 2023 were included. Dynamic changes were defined as the difference between NLR and PLR on day 1 of cycles 1 and 2.

Results

Patients with increased NLR or PLR had an independently increased risk of disease progression at the first response evaluation (odds ratio [OR] 5.26, P = .005; OR 2.29, P = .042), disease progression (hazard ratio [HR] 2.29, P = .003; HR 1.68, P = .027), and death (HR 1.86, P = .027; HR 1.68, P = .037). Furthermore, patients with a decrease in NLR showed longer progression-free survival, with HRs of 0.36 (P < .001) for those with low pre-ICI NLR and 0.52 (P = .041) for those with high pre-ICI NLR, compared to those with increased NLR.

Conclusions

Increased NLR or PLR was associated with adverse outcomes after ICI treatment in patients with R/M HNSCC.

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NLR和PLR的早期动态变化对头颈部鳞状细胞癌免疫检查点抑制剂疗效的预测价值

目的我们分析了中性粒细胞-淋巴细胞比值（NLR）和血小板-淋巴细胞比值（PLR）的动态变化对接受免疫检查点抑制剂（ICIs）治疗的复发性和/或转移性（R/M）头颈部鳞状细胞癌（HNSCC）的预测价值：共纳入2018年8月至2023年6月期间接受ICIs治疗的104例R/M HNSCC患者。动态变化定义为第1周期和第2周期第1天NLR和PLR之间的差异.结果：NLR或PLR增加的患者在首次反应评估时疾病进展风险独立增加（几率比[OR]5.26，P = .005；OR 2.29，P = .042）、疾病进展（危险比[HR]2.29，P = .003；HR 1.68，P = .027）和死亡（HR 1.86，P = .027；HR 1.68，P = .037）。此外，与NLR升高的患者相比，NLR降低的患者无进展生存期更长，ICI前NLR低的患者HR为0.36（P < .001），ICI前NLR高的患者HR为0.52（P = .041）：结论：NLR或PLR升高与R/M HNSCC患者接受ICI治疗后的不良预后有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.

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