{"title":"Acidosis and ischemic brain damage.","authors":"B K Siesjö","doi":"10.1007/BF03160355","DOIUrl":null,"url":null,"abstract":"<p><p>It is now widely accepted that acidosis is an important component of the pathogenetic events that lead to ischemic brain damage. The objective with this article is to recall the evolution of the concept, to describe the conditions under which tissue acidosis arises and causes enhanced brain damage, and to probe into the cellular and molecular mechanisms involved.</p>","PeriodicalId":77753,"journal":{"name":"Neurochemical pathology","volume":"9 ","pages":"31-88"},"PeriodicalIF":0.0000,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03160355","citationCount":"361","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF03160355","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 361
Abstract
It is now widely accepted that acidosis is an important component of the pathogenetic events that lead to ischemic brain damage. The objective with this article is to recall the evolution of the concept, to describe the conditions under which tissue acidosis arises and causes enhanced brain damage, and to probe into the cellular and molecular mechanisms involved.
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