Estimation of Multi-Component Flow in the Kidney with Multi-b-value Spectral Diffusion.

ArXiv Pub Date : 2025-07-30

Mira M Liu, Thomas Gladytz, Jonathan Dyke, Ian Bolger, Jonas Jasse, Sergio Calle, Tanner Crews, Surya Seshan, Steven Salvatore, Isaac Stillman, Thangamani Muthukumar, Bachir Taouli, Samira Farouk, Octavia Bane, Sara Lewis

{"title":"Estimation of Multi-Component Flow in the Kidney with Multi-b-value Spectral Diffusion.","authors":"Mira M Liu, Thomas Gladytz, Jonathan Dyke, Ian Bolger, Jonas Jasse, Sergio Calle, Tanner Crews, Surya Seshan, Steven Salvatore, Isaac Stillman, Thangamani Muthukumar, Bachir Taouli, Samira Farouk, Octavia Bane, Sara Lewis","doi":"","DOIUrl":null,"url":null,"abstract":"Purpose: Examine the theory and potential clinical application of estimated intravoxel 'flow' of separated perfusion, tubular flow, and diffusion from multi-b-value DWI in kidney allografts.Methods: Multi-b-value DWI (9 b-values; 0-800 s/mm2) from a kidney cortex is simulated with anisotropic and non-Gaussian (i.e. anomalous) vascular, tubular, and tissue components and analyzed with a Bayesian biexponential, least-squares triexponential, and spectral diffusion MRI. Comparison and application of biexponential, triexponential, and spectral diffusion <math><mrow><mi>f</mi> <mi>D</mi></mrow> </math> is demonstrated in a two-center study of 54 kidney allografts patients (21F/33M, 48.8±10.5years) and compared to fibrosis (Banff 2017 interstitial fibrosis and tubular atrophy score 0-6 from clinical biopsies of the renal cortex), impaired kidney function (CKD-EPI 2021 eGFR<45ml/min/1.73m2), and proteinuria.Results: Spectral diffusion <math><mrow><mi>f</mi> <mi>D</mi></mrow> </math> demonstrated strong correlation to input <math><mrow><mi>f</mi> <mi>D</mi></mrow> </math> of the simulated anisotropic and anomalous components. It agreed with both three-component diffusion <math> <mrow> <mfenced><mrow><mi>y</mi> <mo>=</mo> <mfenced><mrow><mn>1.10</mn> <mi>x</mi> <mo>-</mo> <mn>0.1</mn> <mo>,</mo> <msup><mi>R</mi> <mn>2</mn></msup> <mo>=</mo> <mn>0.74</mn></mrow> </mfenced> </mrow> </mfenced> </mrow> </math> and two-component diffusion <math> <mrow> <mfenced><mrow><mi>y</mi> <mo>=</mo> <mn>1.01</mn> <mo>+</mo> <mn>0.2</mn> <mo>,</mo> <msup><mi>R</mi> <mn>2</mn></msup> <mo>=</mo> <mn>0.88</mn></mrow> </mfenced> </mrow> </math> . <math><mrow><mi>f</mi> <mi>D</mi></mrow> </math> showed similar or improved agreement and correlation to input than individual parameters, and spectral diffusion showed similar or improved agreement than corresponding bi- and triexponential models. In kidney allografts, <math><mrow><mi>f</mi> <mi>D</mi></mrow> </math> from spectral diffusion showed that higher allograft fibrosis score had higher <math><mrow><mi>f</mi> <msub><mi>D</mi> <mrow><mi>t</mi> <mi>i</mi> <mi>s</mi> <mi>s</mi> <mi>u</mi> <mi>e</mi></mrow> </msub> </mrow> </math> (f-stat=3.86, p=0.02) and that impaired allograft function showed reduced <math><mrow><mi>f</mi> <msub><mi>D</mi> <mrow><mi>t</mi> <mi>u</mi> <mi>b</mi> <mi>u</mi> <mi>l</mi> <mi>e</mi></mrow> </msub> </mrow> </math> (Mann-Whitney U-test=-2.14, p=0.04). Across diagnostic groups of function and fibrosis, <math><mrow><mi>f</mi> <msub><mi>D</mi> <mrow><mi>v</mi> <mi>a</mi> <mi>s</mi> <mi>c</mi> <mi>u</mi> <mi>l</mi> <mi>a</mi> <mi>r</mi></mrow> </msub> </mrow> </math> negatively correlated with proteinuria <math> <mrow> <mfenced><mrow><mi>y</mi> <mo>=</mo> <mo>-</mo> <mn>348</mn> <mi>x</mi> <mo>+</mo> <mn>1144</mn> <mo>,</mo> <mi>p</mi> <mo>=</mo> <mn>0.035</mn> <mspace></mspace> <msup><mi>R</mi> <mn>2</mn></msup> <mo>=</mo> <mn>0.82</mn></mrow> </mfenced> </mrow> </math> .Conclusions: Spectral diffusion MRI with multi-Gaussian <math><mrow><mi>f</mi> <mi>D</mi></mrow> </math> as a flow proxy separated different anomalous and anisotropic diffusion components of perfusion, tubular flow, and tissue diffusion and may hold clinical value in diffusion MRI of kidney pathophysiology.","PeriodicalId":93888,"journal":{"name":"ArXiv","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343220/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ArXiv","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Examine the theory and potential clinical application of estimated intravoxel 'flow' of separated perfusion, tubular flow, and diffusion from multi-b-value DWI in kidney allografts.

Methods: Multi-b-value DWI (9 b-values; 0-800 s/mm²) from a kidney cortex is simulated with anisotropic and non-Gaussian (i.e. anomalous) vascular, tubular, and tissue components and analyzed with a Bayesian biexponential, least-squares triexponential, and spectral diffusion MRI. Comparison and application of biexponential, triexponential, and spectral diffusion $f D$ is demonstrated in a two-center study of 54 kidney allografts patients (21F/33M, 48.8±10.5years) and compared to fibrosis (Banff 2017 interstitial fibrosis and tubular atrophy score 0-6 from clinical biopsies of the renal cortex), impaired kidney function (CKD-EPI 2021 eGFR<45ml/min/1.73m²), and proteinuria.

Results: Spectral diffusion $f D$ demonstrated strong correlation to input $f D$ of the simulated anisotropic and anomalous components. It agreed with both three-component diffusion $(y = (1.10 x - 0.1, R^{2} = 0.74))$ and two-component diffusion $(y = 1.01 + 0.2, R^{2} = 0.88)$ . $f D$ showed similar or improved agreement and correlation to input than individual parameters, and spectral diffusion showed similar or improved agreement than corresponding bi- and triexponential models. In kidney allografts, $f D$ from spectral diffusion showed that higher allograft fibrosis score had higher $f D_{t i s s u e}$ (f-stat=3.86, p=0.02) and that impaired allograft function showed reduced $f D_{t u b u l e}$ (Mann-Whitney U-test=-2.14, p=0.04). Across diagnostic groups of function and fibrosis, $f D_{v a s c u l a r}$ negatively correlated with proteinuria $(y = - 348 x + 1144, p = 0.035 R^{2} = 0.82)$ .

Conclusions: Spectral diffusion MRI with multi-Gaussian $f D$ as a flow proxy separated different anomalous and anisotropic diffusion components of perfusion, tubular flow, and tissue diffusion and may hold clinical value in diffusion MRI of kidney pathophysiology.

Abstract Image

微信好友朋友圈 QQ好友复制链接

本刊更多论文

利用光谱弥散核磁共振成像量化多室流动。

目的：利用多b值扩散加权成像和多高斯模型估算肾脏中以ml/100g/min为单位的fD多室体内流量：介绍并模拟了利用水运输时间量化fD的多高斯模型。多室各向异性 DWI 信号是通过（1）刚性双指数模型、（2）刚性三指数模型和（3）体内非相干运动（频谱扩散）扩散谱成像模型进行模拟分析的。这项应用在一项双中心研究中得到了验证，研究对象是 54 例肾脏同种异体移植物，这些移植物具有 9 个 b 值的高级 DWI，并按功能（CKD-EPI 2021 eGFRR）进行了分割：对于模拟的三室各向异性扩散（y=1.08x+0.1，R2=0.71）和两室各向异性扩散（y=0.91x+0.6，R2=0.74），频谱扩散与真实情况有很强的相关性，在室数可变的情况下，频谱扩散优于刚性模型。使用{\lambda}=0.1的固定正则化参数，计算量增加了208倍，与体素交叉验证正则化结果一致（一致性相关系数=0.99）。肾脏同种异体组织的频谱扩散显示组织实质区的 fD 显著增加（f-stat=3.86，p=0.02）。功能受损的异体移植物肾小管fD明显下降（Mann-Whitney Utest t-stat=-2.14, p=0.04）：结论：即使在肾脏等存在中度各向异性的情况下，也能通过多高斯扩散的 fD 以毫升/100 克/分钟为单位估算出定量的多腔静脉内血流。采用多高斯模型和固定正则化参数的频谱扩散技术，在肾脏等生理分区数量可变的器官中大有可为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

ArXiv

自引率

0.00%

发文量