Is Family History for the Management of Cardiovascular Health in Youth Still Relevant in Clinical Practice?

IF 5.7 2区医学 Q1 PERIPHERAL VASCULAR DISEASE Current Atherosclerosis Reports Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI:10.1007/s11883-024-01232-4

Daphney Kernizan, Sean Connolly, Dima Turpin, Abbas Zaidi, Carissa M Baker-Smith

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Abstract

Purpose of review: Family history of premature cardiovascular disease is a strong predictor of individual cardiovascular risk. However, family history is not always available and not always reliable. Roughly 80% of health outcomes are influenced not by genetic risk but by societal factors, including adverse health behaviors and environment. Furthermore, in the present age of genetic testing, laboratory evaluations, and imaging, a key question remains: What is the contemporary relevance of family history screening in the management of cardiovascular disease in youth?

Recent findings: Knowledge of an individual's family history can help clinicians identify not only inherited risk but also familial clustering of unhealthy behaviors and environmental adversity contributing to enhanced cardiovascular disease risk in youth. For those at greatest risk, prevention strategies can be applied sooner and more conservatively. Integrating family history into clinical practice is crucial for cardiovascular risk assessment and for optimizing outcomes, but, in some cases, is more reflective of social factors.

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临床实践中，青少年心血管健康管理的家族史是否仍有意义？

回顾的目的：过早患心血管疾病的家族史是个人心血管风险的有力预测因素。然而，家族史并不总是可以获得，也并不总是可靠。大约 80% 的健康结果不是受遗传风险的影响，而是受社会因素（包括不良健康行为和环境）的影响。此外，在基因检测、实验室评估和成像技术发达的今天，一个关键问题依然存在：家族史筛查在当代青少年心血管疾病管理中的意义何在？了解个人的家族史不仅能帮助临床医生识别遗传风险，还能识别导致青少年心血管疾病风险增加的不健康行为和环境逆境的家族聚集。对于风险最大的人群，可以更早、更保守地采取预防策略。将家族史纳入临床实践对于心血管风险评估和优化治疗效果至关重要，但在某些情况下，家族史更能反映社会因素。

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来源期刊

Current Atherosclerosis Reports 医学-

CiteScore

9.00

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.

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