Zhen Liang , Carl R. Walkley , Jacki E. Heraud-Farlow
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引用次数: 0
Abstract
Adenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2, respectively. A-to-I editing by ADAR1 is also critical in regulating hematopoiesis. This review will focus on the role of A-to-I RNA editing and ADAR enzymes, particularly ADAR1, during normal hematopoiesis in humans and mice. Furthermore, we will discuss Adar1 mouse models that have been developed to understand the contribution of ADAR1 to hematopoiesis and its role in innate immune pathways.
腺苷转肌苷（A-to-I）RNA 编辑在调节正常发育和稳态中发挥着重要作用。这一过程由作用于 RNA 的腺苷脱氨酶（ADAR）家族蛋白催化。A-I编辑调节的最广为人知的生物过程是先天性免疫和神经系统发育，分别归功于ADAR1和ADAR2。ADAR1 进行的 A 到 I 编辑在调节造血过程中也至关重要。这篇综述将重点讨论 A 到 I RNA 编辑和 ADAR 酶（尤其是 ADAR1）在人类和小鼠正常造血过程中的作用。此外，我们还将讨论为了解 ADAR1 对造血的贡献及其在先天性免疫途径中的作用而开发的 Adar1 小鼠模型。
期刊介绍：
Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.
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