A field evaluation of a new porcine circovirus type 2d and Mycoplasma hyopneumoniae bivalent vaccine in herds suffering from subclinical PCV2d infection and enzootic pneumonia.

IF 1.8 3区 农林科学 Q2 VETERINARY SCIENCES Veterinary Medicine and Science Pub Date : 2024-09-01 DOI:10.1002/vms3.70001
Sehyeong Ham, Jeongmin Suh, Chonghan Kim, Byoung-Joo Seo, Gyeong-Seo Park, Chanhee Chae
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Abstract

Background: This field efficacy study was designed to determine the efficacy of a new bivalent vaccine containing porcine circovirus type 2d (PCV2d) and Mycoplasma hyopneumoniae at three independent pig farms.

Methods: Three pig farms were selected based on their history of subclinical PCV2 infection and enzootic pneumonia. Each farm housed a total of 40, 18-day-old pigs that were randomly allocated to 1 of 2 treatment groups. Pigs were administered a 2.0 mL dose of the bivalent vaccine intramuscularly at 21 days of age in accordance with the manufacturer's recommendations, whereas unvaccinated pigs were administered a single dose of phosphate-buffered saline at the same age.

Results: Clinically, the average daily weight gain of vaccinated groups was significantly higher (p < 0.05) than those of unvaccinated animals during the growing (70-112 days of age), finishing (112-175 days of age) and overall (3-175 days of age) stages of production. Vaccinated animals elicited neutralizing anti-PCV2 antibodies and PCV2d-specific interferon-γ secreting cells (IFN-γ-SC), which reduced the amount of PCV2d genomic copies in blood and reduced lymphoid lesions severity when compared with unvaccinated animals. Similarly, vaccinated animals elicited M. hyopneumoniae-specific IFN-γ-SC, which reduced the amount of M. hyopneumoniae in the larynx and reduced lung lesions severity.

Conclusions: The result of the field trial demonstrated that the bivalent vaccine was efficacious in the protection of swine herds suffering from subclinical PCV2d infection and enzootic pneumonia.

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新型猪圆环病毒 2d 型和肺炎支原体二价疫苗在亚临床 PCV2d 感染和流行性肺炎猪群中的实地评估。
背景:本现场药效研究旨在确定含有猪圆环病毒 2d 型(PCV2d)和肺炎支原体的新型二价疫苗在三个独立猪场的药效:根据猪场亚临床 PCV2 感染和流行性肺炎的历史,选择了三个猪场。每个猪场共饲养 40 头 18 日龄猪,随机分配到 2 个治疗组中的 1 个。按照生产商的建议,猪在 21 日龄时肌肉注射 2.0 mL 剂量的二价疫苗,而未接种疫苗的猪则在同一日龄注射单剂量磷酸盐缓冲盐水:从临床上看,接种疫苗组的平均日增重显著高于未接种疫苗组(p 结论:接种疫苗组的平均日增重显著高于未接种疫苗组):现场试验结果表明,二价疫苗可有效保护患有亚临床 PCV2d 感染和流行性肺炎的猪群。
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来源期刊
Veterinary Medicine and Science
Veterinary Medicine and Science Veterinary-General Veterinary
CiteScore
3.00
自引率
0.00%
发文量
296
期刊介绍: Veterinary Medicine and Science is the peer-reviewed journal for rapid dissemination of research in all areas of veterinary medicine and science. The journal aims to serve the research community by providing a vehicle for authors wishing to publish interesting and high quality work in both fundamental and clinical veterinary medicine and science. Veterinary Medicine and Science publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper. We aim to be a truly global forum for high-quality research in veterinary medicine and science, and believe that the best research should be published and made widely accessible as quickly as possible. Veterinary Medicine and Science publishes papers submitted directly to the journal and those referred from a select group of prestigious journals published by Wiley-Blackwell. Veterinary Medicine and Science is a Wiley Open Access journal, one of a new series of peer-reviewed titles publishing quality research with speed and efficiency. For further information visit the Wiley Open Access website.
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