Photodynamic therapy combined with voriconazole of extensive ulcer caused by Trichosporon asahii

IF 3.1 3区 医学 Q2 ONCOLOGY Photodiagnosis and Photodynamic Therapy Pub Date : 2024-08-24 DOI:10.1016/j.pdpdt.2024.104313
Shuting Chen , Yuwu Luo , Hui Wu , Jing Zhang , Wei Li
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Abstract

Trichosporon species are part of the normal microbiota of humans which can cause both superficial and invasive infections, primarily affecting immunocompetent and immunocompromised hosts, respectively. Giant ulcer caused by Trichosporon asahii is relatively uncommon in immunocompetent hosts. Increased drug resistance and biofilm-associated virulence makes the treatment of infectious ulcers challenging. Herein, we present a case of a massive ulcer caused by T. asahii which resulted in completed healing when treated with photodynamic therapy (PDT) and voriconazole. It provided the feasibility for PDT combined with antifungal drugs to treat similar refractory cases.

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光动力疗法联合伏立康唑治疗旭三代孢子虫引起的大面积溃疡。
三代孢子菌是人类正常微生物群的一部分,可引起表皮感染和侵袭性感染,分别主要影响免疫功能健全的宿主和免疫功能低下的宿主。在免疫功能正常的宿主中,旭三代孢子菌引起的巨型溃疡并不常见。耐药性和生物膜相关毒力的增加使感染性溃疡的治疗面临挑战。在此,我们介绍了一例由阿萨伊曲霉菌引起的大面积溃疡病例,该病例在接受光动力疗法(PDT)和伏立康唑治疗后完全愈合。这为光动力疗法结合抗真菌药物治疗类似难治性病例提供了可行性。
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来源期刊
CiteScore
5.80
自引率
24.20%
发文量
509
审稿时长
50 days
期刊介绍: Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.
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