Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Clinical efficacy of curettage combined with 5-aminolevulinic acid photodynamic therapy in treating recalcitrant acral warts","authors":"Long Zhang ,&nbsp;Yang He ,&nbsp;Juan Yuan ,&nbsp;Wen Ding ,&nbsp;Xia Lei ,&nbsp;Qionghui Cheng ,&nbsp;Nian Chen","doi":"10.1016/j.pdpdt.2026.105373","DOIUrl":"10.1016/j.pdpdt.2026.105373","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Viral warts are benign proliferative skin lesions caused by the human papillomavirus (HPV) and are contagious among humans. Currently, there are no effective treatments to address the high recurrence rate of viral warts, presenting challenges in achieving their complete eradication. The aim of this study was to evaluate the efficacy and safety of curettage combined with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for the treatment of recalcitrant acral warts.</div></div><div><h3>Methods</h3><div>Our study was carried out between July 2023 to June 2025, and the clinical data of 50 patients diagnosed with acral warts were retrospectively collected. Patients were assigned to the curettage group (<em>n</em> = 24) or the combination group (<em>n</em> = 26) based on whether they received photodynamic therapy after curettage. The clinical response effects, recurrence rate and adverse reactions of the two groups were observed and compared.</div></div><div><h3>Results</h3><div>The cure rate in the combination group was 80.8% (21/26), which was significantly higher than 45.8% (11/24) in curettage group. The recurrence rate in the combination group was 19.2% (5/26), which was lower than 54.2% (13/24) in curettage group (<em>P</em> &lt; 0.05). After three months of follow-up, moderate pain was the main adverse reaction in both groups, and no systemic adverse reactions were observed.</div></div><div><h3>Conclusion</h3><div>Our results suggest that curettage combined with ALA-PDT is promising as a safe and effective therapy for patients with recalcitrant acral warts.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105373"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accommodation and peripheral retinal defocus in school-age myopic children","authors":"Simin Zhang ,&nbsp;Riping Zhang ,&nbsp;Tsz Kin Ng ,&nbsp;Vishal Jhanji ,&nbsp;Jinyu Li","doi":"10.1016/j.pdpdt.2026.105351","DOIUrl":"10.1016/j.pdpdt.2026.105351","url":null,"abstract":"<div><h3>Background</h3><div>To investigate the influences of accommodation on peripheral retinal defocus in school-age children with corrective glasses before and after cycloplegia.</div></div><div><h3>Methods</h3><div>In total, 69 children, aged 7–12 years, with spherical equivalent between +1.75 D and -9.75 D were recruited. Peripheral retinal defocus values (RDV) before and after cycloplegia were measured using multispectral refraction tomography (MRT), and compared among different severities of myopia. The correlation between retinal defocus and axial length was also evaluated. The parameters were measured in different circular areas (15°, 30°, 45°, and 53°), annular areas (15°-30°, 30°-45°, and 45°-53°), and quadrants (superior, inferior, temporal, and nasal). Data was obtained from the right eyes of all participants. An average of three values was used for analysis.</div></div><div><h3>Results</h3><div>Before cycloplegia, significant variations were identified in the inferior retinal quadrant across different severities of myopia and age groups. After cycloplegia, multiple retinal areas showed significant differences among different severities of myopia, while there were no differences in each area among different age groups. After cycloplegia, retinal defocus shifted significantly towards more hyperopic across all areas, except for the RDV-15° area. Superior retinal defocus was positively correlated with axial length before and after cycloplegia, whereas inferior retinal defocus was negatively correlated with axial length before cycloplegia.</div></div><div><h3>Conclusion</h3><div>This study revealed various distribution of defocus across different retinal areas in school-age children. Peripheral retinal defocus can be induced with cycloplegia. Alterations in accommodation can influence peripheral retinal defocus in school-age children.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105351"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes following transurethral laser ablation with topical versus general or spinal anesthesia for non–muscle-invasive bladder cancer: A Japanese single-center pilot study","authors":"Shinkuro Yamamoto ,&nbsp;Satoshi Fukata ,&nbsp;Sho Shimasaki ,&nbsp;Yoshitaka Kurano ,&nbsp;Erika Yamashita ,&nbsp;Kaya Atagi ,&nbsp;Ryu Shigehisa ,&nbsp;Hiroto Osakabe ,&nbsp;Tomoya Nao ,&nbsp;Tsutomu Shimamoto ,&nbsp;Hideo Fukuhara ,&nbsp;Nobutaka Shimizu ,&nbsp;Shingo Ashida ,&nbsp;Keiji Inoue","doi":"10.1016/j.pdpdt.2026.105376","DOIUrl":"10.1016/j.pdpdt.2026.105376","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare transurethral laser ablation (TULA) outcomes for non-muscle invasive bladder cancer (NMIBC) performed under topical anesthesia versus general or spinal anesthesia in a Japanese cohort.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed 28 patients who underwent 32 TULA sessions with a 980-nm diode laser from February 2024 to June 2025. Patients treated between February and October 2024 received TULA under general or spinal anesthesia (general or spinal anesthesia group, <em>n</em> = 14). Those treated between October 2024 and June 2025 underwent TULA with topical lidocaine lubrication (topical anesthesia group, <em>n</em> = 18). We compared demographic, perioperative, and short-term oncologic outcomes. Complications were graded according to Clavien–Dindo classification.</div></div><div><h3>Results</h3><div>Baseline characteristics were similar between groups. Operation time, treatment energy, and treatment duration were comparable. The topical anesthesia group experienced a significantly shorter median post-treatment hospital stay (1 [1–1] vs. 2 [2–2.75] days; <em>p</em> &lt; 0.001) and catheterization duration (0 [0–0] vs. 1 [1–1] days; <em>p</em> &lt; 0.001). Complications were mild (grade 1–2), affecting one general or spinal anesthesia group patient (7.1%) and three topical anesthesia group patients (16.7%). Under strict follow-up criteria (≥90 and ≥180 days), 3-month recurrence-free survival (RFS) was 100% (14/14) in both groups, and 6-month RFS was 92.3% (12/13) in the anesthesia group vs. 58.3% (7/12) in the topical anesthesia group. Kaplan–Meier analysis showed no statistically significant difference (<em>p</em> = 0.19).</div></div><div><h3>Conclusions</h3><div>TULA under topical anesthesia for selected NMIBC patients was associated with shorter post-treatment hospital stays and a catheter-free recovery. Early oncologic outcomes, including short-term RFS, seem promising; however, these preliminary, pilot-scale findings warrant further validation in larger studies. TULA with topical anesthesia may provide perioperative advantages compared with procedures performed under general or spinal anesthesia, particularly in older patients or those with significant comorbidities.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105376"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal susceptibility testing and clinical efficacy observation of methylene blue photodynamic therapy in treating trichophyton indotineae infections","authors":"Wei-Lun Xu ,&nbsp;Gao-Yuan Peng ,&nbsp;Shu-Lei Qin ,&nbsp;Yan-Qing Zheng ,&nbsp;Jia-Can Huang ,&nbsp;Jun-Meng Zhou ,&nbsp;Ming-Yu Zheng ,&nbsp;Dong-Yan Zheng ,&nbsp;Xinyu Zhang","doi":"10.1016/j.pdpdt.2026.105363","DOIUrl":"10.1016/j.pdpdt.2026.105363","url":null,"abstract":"<div><div>Superficial fungal infections caused by Trichophyton indotineae are spreading globally, with mutations in its SQLE gene (F397L/L393S) increasing resistance to traditional antifungals like terbinafine, creating an urgent need for new therapies. This study evaluated the clinical efficacy of methylene blue-mediated photodynamic therapy (MB-PDT). In vitro susceptibility testing was performed on a multidrug-resistant T. indotineae strain isolated from a 25-year-old Indian male with extensive skin lesions (confirmed by ITS sequencing). A randomized controlled trial was conducted: the experimental group (forearm lesions) received topical 1 % methylene blue plus 630 ± 5 nm red light irradiation (100 J/cm², once weekly for 4 weeks), while the control group (other lesions) were treated with topical 1 % terbinafine cream twice daily. Results showed the strain was highly sensitive to methylene blue (MIC = 1.0 μg/mL) but resistant to terbinafine (MIC = 8.0 μg/mL). After 2 weeks, the experimental group achieved scaling resolution and negative fungal microscopy, with sustained efficacy at 4 weeks; the control group retained residual hyphae. Conclusion: MB-PDT rapidly eradicates drug-resistant T. indotineae infections, outperforming traditional topical agents and providing a safe, effective alternative for drug-resistant dermatophytosis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105363"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy combined with systemic treatment achieves significant remission in microsatellite instability-high locally advanced colorectal cancer: A case report and literature review","authors":"Jingwei Ma ,&nbsp;Jike Hu ,&nbsp;Yali Li ,&nbsp;Lingzhi Liao ,&nbsp;Jing Liu ,&nbsp;Yile Qi ,&nbsp;Jiahui Ma ,&nbsp;Lin Xiang ,&nbsp;Hao Chen","doi":"10.1016/j.pdpdt.2026.105361","DOIUrl":"10.1016/j.pdpdt.2026.105361","url":null,"abstract":"<div><div>Patients with locally advanced colorectal cancer (LACRC) are at high risk of recurrence and metastasis and benefit little from neoadjuvant radiotherapy (nCRT) or neoadjuvant chemotherapy (nCT). Although the Microsatellite instability-high (MSI-H) status has been identified as a valid predictive marker for immunotherapy response, heterogeneity in the treatment response remains. In this study, we report a case of a 70-year-old woman with locally advanced rectal cancer with MSI-H status who had no chance of surgery due to tumor invasion of the uterine wall (cT3N2Mx) and who underwent a systemic treatment regimen of photodynamic therapy (PDT) in combination with a PD-1 inhibitor and antiangiogenic therapy. The treatment consisted of four tumor-directed PDT sessions and a 6-cycle systemic regimen (sintilimab/tislelizumab 200 mg/q3W combined with bevacizumab 7.5 mg/kg/q3W and capecitabine 1000 mg/m²). After six cycles, the tumor achieved near-complete remission, with negative mesorectal fascia (MRF) and extramural vascular invasion (EMVI) status. As of the most recent telephone follow-up prior to manuscript submission, the patient remained progression-free for 17 months. This case demonstrates the synergistic efficacy of PDT combined with immune-targeted therapy in MSI-H LACRC, offering a novel non-surgical treatment option for organ preservation in such patients.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105361"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision conversion of colorectal cancer lung metastases: A personalized quadruplet regimen integrating photodynamic therapy with targeted, immunotherapy, and chemotherapy","authors":"Qinying Han ,&nbsp;Lei Gao ,&nbsp;Yunpeng Wang ,&nbsp;Zhuanfang Wang ,&nbsp;Lijuan He ,&nbsp;Ben Liu ,&nbsp;Jike Hu ,&nbsp;Bo Xu ,&nbsp;Hao Chen","doi":"10.1016/j.pdpdt.2026.105362","DOIUrl":"10.1016/j.pdpdt.2026.105362","url":null,"abstract":"<div><h3>Significance</h3><div>Colorectal cancer (CRC) has a high incidence and mortality rate, with lung metastasis being the second most common site. Current treatments have limited efficacy, and novel approaches are needed.</div></div><div><h3>Approach</h3><div>We report a case of a middle-aged female with CRC and lung metastasis treated with four cycles of PDT and five cycles of systemic therapy, including chemotherapy, targeted therapy, and immunotherapy.</div></div><div><h3>Results</h3><div>After treatment, the lung metastases showed cystic changes, and the primary tumor significantly regressed (TRG: AJCC 0, Becker 1a). The patient successfully underwent surgical treatment.</div></div><div><h3>Conclusions</h3><div>This multimodal therapy shows promise in CRC lung metastasis, offering new insights for treatment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105362"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of photodynamic therapy with multimodal therapy achieves anus preservation in MSS ultra-low rectal cancer—A case report and literature review","authors":"Jing Liu ,&nbsp;Lingzhi Liao ,&nbsp;Jiahui Ma ,&nbsp;Jingwei Ma ,&nbsp;Yali Li ,&nbsp;Yile Qi ,&nbsp;Baohong Gu ,&nbsp;Jike Hu ,&nbsp;Ewetse Paul Maswikiti ,&nbsp;Hao Chen","doi":"10.1016/j.pdpdt.2025.105299","DOIUrl":"10.1016/j.pdpdt.2025.105299","url":null,"abstract":"<div><div>The preservation of the anus in ultra-low rectal cancer (ULRC) surgery presents considerable clinical challenges. While combined neoadjuvant therapy is considered a pivotal treatment strategy, its effectiveness is constrained by factors such as anatomical location, postoperative complications, systemic toxic reactions, and tumor drug resistance. Photodynamic therapy (PDT), as a localized treatment modality, operates through multiple mechanisms, including the targeted eradication of tumor cells, disruption of the tumor vascular system, reversal of drug resistance, and activation of antitumor immune responses. This article presents a case study of a patient with stage IIIb (cT4N1Mx), microsatellite stable (MSS) ULRC, who successfully achieved tumor downstaging and underwent anus-preserving surgery following a comprehensive treatment regimen. This regimen included PDT, systemic therapy, da Vinci robot-assisted anus-preserving surgery, and anastomotic stent implantation. The patient has achieved a progression-free survival (PFS) exceeding 14 months. At present, the patient exhibits satisfactory defecation function, and no complications, such as anastomotic fistula, have been observed.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105299"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal structural alterations in patients with type 2 diabetes mellitus without clinical diabetic retinopathy using ultra-widefield swept-source OCTA: A cross-sectional study","authors":"Cong Chen ,&nbsp;Wen-Jing Zhang ,&nbsp;Qin Ding ,&nbsp;Shu-Min Shen ,&nbsp;Ya Ye ,&nbsp;Zhen Huang ,&nbsp;Ming Yan ,&nbsp;Yan-Ping Song","doi":"10.1016/j.pdpdt.2026.105349","DOIUrl":"10.1016/j.pdpdt.2026.105349","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to quantitatively examine choroidal structural alterations in patients with type 2 diabetes mellitus (T2DM) of varying disease duration who did not present with clinical diabetic retinopathy (DR), using ultra-widefield swept-source optical coherence tomography angiography (UWF-SS-OCTA).</div></div><div><h3>Methods</h3><div>This cross-sectional study included 200 patients with T2DM without DR (200 eyes) and 78 healthy individuals (78 eyes). Based on diabetes duration, patients were categorized into three groups: &lt;5 years (DM1, <em>n</em> = 80), 5 to 10 years (DM2, <em>n</em> = 60), and &gt;10 years (DM3, <em>n</em> = 60). UWF-SS-OCTA was used to quantify choroidal thickness (CT), choroidal vascular volume (CVV), and choroidal vascularity index (CVI) in the peripapillary region, the macula-centered UWF central area (1–12 mm), and the peripheral area (12–21 mm). One-way analysis of variance with post hoc testing assessed intergroup differences. Multivariable linear regression was performed to evaluate the associations between diabetes duration and choroidal parameters.</div></div><div><h3>Results</h3><div>Relative to healthy controls, patients in the DM3 group exhibited significant reductions in CT and CVV in all evaluated regions, along with decreases in CVI in most regions (all <em>p</em> &lt; 0.05). When diabetic subgroups were compared, the DM3 group demonstrated significantly lower CT and CVV across all regions compared with the DM1 and DM2 groups (all <em>p</em> &lt; 0.05). Central CVI showed a progressive decline with longer diabetes duration, while peripheral CVI differed significantly only between the DM3 and DM1 groups. Except for peripheral CVI, CT, CVV, and central CVI across all assessed regions were independently and negatively associated with diabetes duration (all <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Patients with T2DM without DR demonstrated early choroidal thinning and vascular deterioration, which progressively worsened with longer diabetes duration. UWF-SS-OCTA revealed that the choroidal alterations in T2DM without DR were widespread but most pronounced in the peripheral regions, highlighting the importance of wide-field imaging for comprehensive assessment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105349"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic analysis reveals the molecular mechanisms of methylene blue-mediated photodynamic therapy against Microsporum canis","authors":"Gaoyuan Peng ,&nbsp;Weilun Xu ,&nbsp;Shulei Qin ,&nbsp;Junmeng Zhou ,&nbsp;Kaisu Pan ,&nbsp;Lan Huang ,&nbsp;Dongyan Zheng ,&nbsp;Xinyu Zhang","doi":"10.1016/j.pdpdt.2026.105364","DOIUrl":"10.1016/j.pdpdt.2026.105364","url":null,"abstract":"<div><h3>Background</h3><div>Microsporum canis is a predominant cause of dermatophytosis, presenting a significant therapeutic challenge due to the limitations of conventional antifungal agents and the emergence of drug resistance. Methylene Blue-mediated Photodynamic Therapy (MB-PDT) represents a promising alternative; however, the comprehensive transcriptomic response and specific molecular pathways disrupted by this modality in M. canis remain largely elusive.</div></div><div><h3>Methods</h3><div>This study employed RNA-sequencing (RNA-Seq) to elucidate the global transcriptomic response of M. canis to a sub-inhibitory concentration of MB-PDT. Differentially expressed genes (DEGs) were identified, and their biological functions were characterized via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Furthermore, the expression profiles of key marker genes were validated using qRT-PCR.</div></div><div><h3>Results</h3><div>A total of 619 DEGs were identified, comprising 341 upregulated and 278 downregulated genes. Functional enrichment analysis highlighted the \"ribosome\" and \"steroid biosynthesis\" pathways as the most significantly impacted. The transcriptomic profile suggests that MB-PDT induces multi-target oxidative damage, specifically compromising cell membrane integrity, mitochondrial function, and ribosomal activity. Notably, the expression patterns of key marker genes indicate that M. canis activates an intrinsic programmed cell death (PCD) pathway in response to this irreparable oxidative stress.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that MB-PDT exerts its antifungal effect against <em>M. canis</em> through a multi-target mechanism that overwhelms cellular repair systems, ultimately triggering the initiation of PCD. This mode of action may mitigate the risk of resistance development, underscoring MB-PDT as a potent therapeutic alternative for the management of dermatophytosis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105364"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase I/II clinical study of next-generation photodynamic therapy (L-PDT) using talaporfin sodium (Laserphyrin®) for cervical intraepithelial neoplasia: Efficacy, safety, and fertility preservation","authors":"Masaru Sakamoto ,&nbsp;Shuji Takeda ,&nbsp;Arisa Fujiwara ,&nbsp;Momo Hirata ,&nbsp;Sou Hirose ,&nbsp;Kazuko Matsuoka ,&nbsp;Kenji Umayahara ,&nbsp;Keiichi Iwaya ,&nbsp;Tadao Tanaka ,&nbsp;Aikou Okamoto","doi":"10.1016/j.pdpdt.2026.105372","DOIUrl":"10.1016/j.pdpdt.2026.105372","url":null,"abstract":"<div><h3>Background</h3><div>PDT using Photofrin® (P-PDT) has been applied to over 900 gynecologic tumor cases since 1989, demonstrating excellent efficacy and fertility preservation; however, post-treatment photosensitivity has limited its clinical application for CIN and cervical cancer. This study aimed to establish a safe, effective, and fertility-preserving alternative to cervical conization.</div></div><div><h3>Methods</h3><div>To overcome photosensitivity, we conducted a prospective Phase I/II clinical study to evaluate the safety, efficacy, oncological control, and fertility outcomes of L-PDT using talaporfin sodium (Laserphyrin®) and a diode laser for CIN grades 2–3. Forty-three women with biopsy-confirmed CIN2–3 were enrolled. Phase I determined the optimal light dose (50, 75, or 100 J/cm²), and Phase II assessed efficacy and safety at 100 J/cm². Talaporfin sodium (40 mg/m²) was administered intravenously 4 hours before laser irradiation under colposcopic guidance.</div></div><div><h3>Results</h3><div>Complete response (CR) was achieved in 95% (95% CI: 89.1–100%) at 3 months and 98% (95% CI: 93.2–100%) at 6 months after treatment. Original high-risk human papillomavirus clearance was 92.5% at 3 months and 95% at 12 months. Adverse events were mild and transient, including abdominal pain and low-grade fever. No recurrences occurred during a median follow-up of 66.4 months among patients achieving CR. Among women desiring pregnancy, the conception rate was 74% (23/31) and the live birth rate was 79% (27/34), with a low preterm birth rate of 3.7% (1/27). Conclusions: These results suggest that L-PDT is a safe and highly effective non-excisional treatment for CIN that may contribute to fertility preservation; however, potential advantages over conventional conization and laser vaporization need to be confirmed in comparative studies.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"58 ","pages":"Article 105372"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}