Case-control study of the characteristics and risk factors of hot clot artefacts on 18F-FDG PET/CT.

IF 3.5 2区 医学 Q2 ONCOLOGY Cancer Imaging Pub Date : 2024-08-27 DOI:10.1186/s40644-024-00760-1
Jacques Dzuko Kamga, Romain Floch, Kevin Kerleguer, David Bourhis, Romain Le Pennec, Simon Hennebicq, Pierre-Yves Salaün, Ronan Abgral
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Abstract

Introduction: The pulmonary Hot Clot artifact (HCa) on 18F-FDG PET/CT is a poorly understood phenomenon, corresponding to the presence of a focal tracer uptake without anatomical lesion on combined CTscan. The hypothesis proposed in the literature is of microembolic origin. Our objectives were to determine the incidence of HCa, to analyze its characteristics and to identify associated factors.

Methods: All 18F-FDG PET/CT retrieved reports containing the keywords (artifact/vascular adhesion/no morphological abnormality) during the period June 2021-2023 at Brest University Hospital were reviewed for HCa. Each case was associated with 2 control patients (same daily work-list). The anatomical and metabolic characteristics of HCa were analyzed. Factors related to FDG preparation/administration, patient and vascular history were investigated. Case-control differences between variables were tested using Chi-2 test and OR (qualitative) or Student's t-test (quantitative).

Results: Of the 22,671 18F-FDG PET/CT performed over 2 years, 211 patients (0.94%) showed HCa. The focus was single in 97.6%, peripheral in 75.3%, and located independently in the right or left lung (51.1% vs. 48.9%). Mean ± SD values for SUVmax, SUVmean, MTV and TLG were 11.3 ± 16.5, 5.1 ± 5.0, 0.3 ± 0.3 ml and 1.5 ± 2.1 g respectively. The presence of vascular adhesion (p < 0.001), patient age (p = 0.002) and proximal venous access (p = 0.001) were statistically associated with the presence of HCa.

Conclusion: HCa is a real but rare phenomenon (incidence around 1%), mostly unique, intense, small in volume (< 1 ml), and associated with the presence of vascular FDG uptake, confirming the hypothesis of a microembolic origin due to probable vein wall trauma at the injection site.

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18F-FDG PET/CT 热血块伪影特征和风险因素的病例对照研究。
导言:18F-FDG PET/CT 上的肺热凝块伪影(HCa)是一种鲜为人知的现象,它与联合 CT 扫描中出现的无解剖病灶的局灶性示踪剂摄取相对应。文献中提出的假设是微栓塞起源。我们的目的是确定 HCa 的发生率,分析其特征并找出相关因素:方法:对布雷斯特大学医院 2021 年 6 月至 2023 年 6 月期间所有 18F-FDG PET/CT 检索报告中包含关键词(伪影/血管粘连/无形态异常)的 HCa 进行审查。每个病例均与 2 名对照患者(日常工作清单相同)相关联。对 HCa 的解剖和代谢特征进行了分析。还调查了与 FDG 制备/给药、患者和血管病史有关的因素。使用Chi-2检验和OR(定性)或学生t检验(定量)检验变量之间的病例对照差异:在两年内进行的 22671 例 18F-FDG PET/CT 中,有 211 例患者(0.94%)出现 HCa。97.6%的患者为单发病灶,75.3%的患者为外周病灶,病灶独立位于右肺或左肺(51.1% vs. 48.9%)。SUVmax、SUVmean、MTV和TLG的平均值(± SD)分别为11.3±16.5、5.1±5.0、0.3±0.3毫升和1.5±2.1克。血管粘连的存在(p 结论:HCa 是一种真实但罕见的现象:HCa 是一种真实但罕见的现象(发生率约为 1%),大多具有独特性、强度高、体积小 (
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来源期刊
Cancer Imaging
Cancer Imaging ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
7.00
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Cancer Imaging is an open access, peer-reviewed journal publishing original articles, reviews and editorials written by expert international radiologists working in oncology. The journal encompasses CT, MR, PET, ultrasound, radionuclide and multimodal imaging in all kinds of malignant tumours, plus new developments, techniques and innovations. Topics of interest include: Breast Imaging Chest Complications of treatment Ear, Nose & Throat Gastrointestinal Hepatobiliary & Pancreatic Imaging biomarkers Interventional Lymphoma Measurement of tumour response Molecular functional imaging Musculoskeletal Neuro oncology Nuclear Medicine Paediatric.
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