{"title":"Breast Cancer Detection Using Si-Doped MoS2 Channel-Based Thickness Engineered TFET Biosensor","authors":"Priya Kaushal;Gargi Khanna","doi":"10.1109/LSENS.2024.3438872","DOIUrl":null,"url":null,"abstract":"This letter investigates the electrical performance characteristics for breast cancer cell line detection by developing the Si-doped molybdenum disulfide thickness engineered tunnel field effect transistor biosensor. A complete study of the electrostatic field is presented, including the surface potential, electric field, transconductance (g\n<sub>m</sub>\n), threshold voltage (V\n<sub>th</sub>\n), \n<sc>on</small>\n current (I\n<sub>ON</sub>\n), and subthreshold swing. The sensitivity is analyzed in terms of drain current (I\n<sub>ds</sub>\n), g\n<sub>m</sub>\n, V\n<sub>th</sub>\n, I\n<sub>ON</sub>\n, I\n<sub>ON</sub>\n/I\n<sub>OFF</sub>\n ratio, and g\n<sub>m</sub>\n. Further, this study investigates the impact of device geometry variations, specifically cavity thickness, and length on the sensitivity of drain current (\n<inline-formula><tex-math>$\\text{S}_{\\rm{I}_{\\rm{ds}}}$</tex-math></inline-formula>\n), transconductance (\n<inline-formula><tex-math>$\\text{S}_{\\rm{g}_{\\rm{m}}}$</tex-math></inline-formula>\n ), threshold voltage (\n<inline-formula><tex-math>${\\text{S}}_{{{\\rm{V}}_{{\\rm{th}}}}}$</tex-math></inline-formula>\n), and \n<sc>on</small>\n current (\n<inline-formula><tex-math>${\\text{S}}_{{{\\rm{I}}_{{\\rm{ON}}}}}$</tex-math></inline-formula>\n). In addition, the impact of immobilized cell line occupancy on device performance has been examined. The presented biosensor is highly sensitive with increased cavity occupancy resulting in enhanced performance. As a result, array-based screening and diagnosis of breast cancer cells can be accomplished with the device, which is also economical and simpler to fabricate.","PeriodicalId":13014,"journal":{"name":"IEEE Sensors Letters","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Sensors Letters","FirstCategoryId":"1085","ListUrlMain":"https://ieeexplore.ieee.org/document/10623876/","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0
Abstract
This letter investigates the electrical performance characteristics for breast cancer cell line detection by developing the Si-doped molybdenum disulfide thickness engineered tunnel field effect transistor biosensor. A complete study of the electrostatic field is presented, including the surface potential, electric field, transconductance (g
m
), threshold voltage (V
th
),
on
current (I
ON
), and subthreshold swing. The sensitivity is analyzed in terms of drain current (I
ds
), g
m
, V
th
, I
ON
, I
ON
/I
OFF
ratio, and g
m
. Further, this study investigates the impact of device geometry variations, specifically cavity thickness, and length on the sensitivity of drain current (
$\text{S}_{\rm{I}_{\rm{ds}}}$
), transconductance (
$\text{S}_{\rm{g}_{\rm{m}}}$
), threshold voltage (
${\text{S}}_{{{\rm{V}}_{{\rm{th}}}}}$
), and
on
current (
${\text{S}}_{{{\rm{I}}_{{\rm{ON}}}}}$
). In addition, the impact of immobilized cell line occupancy on device performance has been examined. The presented biosensor is highly sensitive with increased cavity occupancy resulting in enhanced performance. As a result, array-based screening and diagnosis of breast cancer cells can be accomplished with the device, which is also economical and simpler to fabricate.