Using Neuromodulators to Improve Scar Formation, Keloids, Rosacea, and Antiaging.

IF 2.5 3区医学 Q2 DERMATOLOGY Dermatologic Surgery Pub Date : 2024-09-01 Epub Date: 2024-07-23 DOI:10.1097/DSS.0000000000004353

Monica Rosales Santillan, David Ozog, Woffles Wu

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引用次数: 0

Abstract

Background: Botulinum toxin A (BoNT-A) treatment has many uses in dermatology. Its mechanism of action and long-term effects for scar formation, rosacea, and antiaging are still being investigated.

Objective: To conduct a literature review on BoNT-A to further investigate its use in scar formation, rosacea, and antiaging.

Methods: A literature review was conducted using PubMed on botulinum toxin treatment for scar formation, rosacea, and antiaging. Studies discussing the toxin mechanism of action and treatment algorithm were included. The authors also provided their personal experience in BoNT-A use for these 3 conditions.

Results: The mechanism of action of Botulinum toxin A in improving scar formation, rosacea, and antiaging is now better understood. While it is effective in the short term, little is still known about how frequently treatment needs to be repeated and if there are any long-term effects.

Conclusion: While in vitro studies have supporting evidence on the mechanism of action of BoNT-A on scar formation, rosacea, and antiaging, further studies are needed to identify long-term treatment effects.

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使用神经调节剂改善疤痕形成、瘢痕疙瘩、红斑痤疮和抗衰老。

背景：肉毒杆菌毒素 A（BoNT-A）治疗在皮肤病学中有许多用途。其对疤痕形成、酒渣鼻和抗衰老的作用机制和长期效果仍在研究中：对 BoNT-A 进行文献综述，进一步研究其在疤痕形成、酒渣鼻和抗衰老方面的应用：使用 PubMed 对肉毒毒素治疗疤痕形成、酒渣鼻和抗衰老的文献进行了综述。其中包括讨论毒素作用机制和治疗算法的研究。作者还提供了他们使用 BoNT-A 治疗这三种疾病的个人经验：结果：A 型肉毒杆菌毒素在改善疤痕形成、酒渣鼻和抗衰老方面的作用机制现已得到更好的理解。虽然肉毒杆菌毒素 A 在短期内有效，但人们对其需要重复治疗的频率以及是否有长期效果仍知之甚少：结论：虽然体外研究为 BoNT-A 在疤痕形成、酒糟鼻和抗衰老方面的作用机制提供了支持性证据，但仍需进一步研究以确定长期治疗效果。

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来源期刊

Dermatologic Surgery 医学-皮肤病学

CiteScore

3.10

自引率

16.70%

发文量

547

期刊介绍： Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.