Dermatologic Surgery最新文献

Background: Hyaluronic acid (HA) is a cornerstone of aesthetic skin treatments due to its vital role in skin hydration and combating aging signs.

Objective: This trial evaluated the efficacy and safety of a novel non-cross-linked HA gel for improving skin quality in a Chinese population.

Materials and methods: In this multicenter, randomized, controlled trial, 420 subjects were enrolled (2:1, treatment: control). The treatment group received three full-face intradermal injections of the HA gel at 3-week intervals, whereas the control group received no intervention. Primary end points were blinded evaluations of the Global Aesthetic Improvement Scale and a composite improvement rate for skin dryness/dullness.

Results: The treatment group showed significantly higher Global Aesthetic Improvement Scale improvement (90.63% vs 3.65%) and composite improvement rates (83.20% vs 3.65%) than control group (p < .0001), with effects sustained for 6 months. Skin hydration and elasticity significantly increased from baseline (p < .05). Peak efficacy rates for fine lines and roughness reached 51.59% and 50.00%, respectively. Adverse events were mild and transient, with decreasing incidence.

Conclusion: This non-cross-linked HA gel effectively enhances skin hydration, elasticity, and texture with sustained 6-month benefits and a favorable safety profile, supporting its use for facial rejuvenation.

Background: Genital and inguinal cutaneous malignancies are uncommon but clinically significant because of complex anatomy and potential morbidity. Nevertheless, these sites remain underrepresented in dermatologic surgery literature and training.

Objective: To practically review the anatomy relevant to cutaneous oncologic surgery of the male and female genitalia and inguinal region, emphasizing landmarks, danger zones, safe planes, and reconstruction.

Methods: A review was conducted. Clinical series, cadaveric studies, and reviews most applicable to dermatologic surgery were prioritized.

Results: Surface landmarks such as the penile and scrotal raphes, clitoral hood and fourchette, and the inguinal ligament help orient dissection. Safe undermining planes include the subdartos tissue of the penis and scrotum and tissue superficial to Scarpa fascia in the groin. Critical danger zones include the dorsal penile and clitoral neurovascular bundles, the ventral urethra at the frenulum and urethral meatus, the Bartholin glands at the posterior vestibule, and the femoral neurovasculature within the femoral triangle.

Conclusion: As Mohs micrographic surgery is increasingly applied to genital and inguinal tumors, dermatologic surgeons will play a growing role in their management. Safe outcomes depend on respecting fascial planes and danger zones, and the principles summarized here provide a practical framework for excision and reconstruction.

Background: Vitiligo is an acquired disorder of pigmentation thought to occur due to loss and dysfunction of melanocytes that causes skin depigmentation.

Objective: To evaluate the effect of fractional carbon dioxide (CO2) laser combined with topical corticosteroid and ultraviolet B narrow band (UVB-NB) in treatment of stable vitiligo.

Patients and methods: Twenty-five patients with stable vitiligo were enrolled. In every patient, the authors selected 2 groups of lesions: that on the right side (group A) were treated with fractional CO2 laser, topical corticosteroid, and UVB-NB, and the lesions on the left side (group B) were treated with topical corticosteroid and UVB-NB.

Results: In group A, only 16% of the patients were not repigmented, whereas most of the patients of group B 72% were not repigmented ( p = .000*). Approximately 20% of the patients of group A showed excellent repigmentation, whereas no patient in group B showed excellent repigmentation ( p = .050*). After treatment, the patients in group A were more satisfied than in group B ( p = .000*).

Conclusion: Triple combination of fractional CO2 laser with topical betamethasone and UVB-NB was more effective in treatment of stable vitiligo than double combination of UVB-NB with topical betamethasone.