Effects of vitamin D supplementation on patients with chronic heart failure: A meta-analysis

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Nutrition Clinique et Metabolisme Pub Date : 2024-08-08 DOI:10.1016/j.nupar.2024.05.001

Qian Tang , Lin Liu , Lin Liu , Min Chen

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Abstract

Objective

To systematically evaluate the effect of vitamin D supplementation on cardiac function in patients with chronic heart failure.

Methods

Search multiple databases to find randomized controlled trials of vitamin D for chronic heart failure from the self-built database until September 1, 2023. Meta-analysis was performed using RevMan5.3 and Stata15.0 software.

Results

Eighteen articles were included. Vitamin D supplementation has improved left ventricular ejection fraction [WMD = 3.18%, 95%CI (1.07, 5.3), P < 0.05] and 6-minute walking distance [MD = −11.54, 95%CI (−22,215, −0.871), P < 0.05], has decreased left ventricular end-diastolic diameter [MD = −1.67, 95%CI (−2.88, −0.46), P < 0.05], left ventricular end-diastolic volume [MD = −11.94, 95%CI (−20.59, −3.29), P < 0.05], N-terminal forebrain natriuretic peptide [WMD = −0.7, 95%CI (0.24, 1.16), P < 0.05].

Conclusion

Vitamin D supplementation can improve cardiac function, inhibit ventricular remodeling, and increase exercise endurance inpatients with chronic heart failure.

INPLASY registration number

202440032.

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维生素 D 补充剂对慢性心力衰竭患者的影响：荟萃分析

目的系统评估维生素D补充剂对慢性心力衰竭患者心脏功能的影响。方法检索多个数据库，从自建数据库中找到截至2023年9月1日的维生素D治疗慢性心力衰竭的随机对照试验。结果共纳入18篇文章。维生素 D 补充剂改善了左心室射血分数[WMD = 3.18%，95%CI (1.07, 5.3)，P <0.05]和 6 分钟步行距离[MD = -11.54，95%CI (-22,215, -0.871, P <0.05]。871), P < 0.05]，左心室舒张末期直径[MD = -1.67, 95%CI (-2.88, -0.46), P < 0.05]、左心室舒张末期容积[MD = -11.结论补充维生素 D 可改善慢性心力衰竭患者的心功能、抑制心室重塑并提高运动耐力。

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来源期刊

Nutrition Clinique et Metabolisme 医学-内分泌学与代谢

CiteScore

0.80

自引率

16.70%

发文量

216

审稿时长

78 days

期刊介绍： Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.