Yu Ye , Shulei Wu , Zaoduan Wu , Qianqian Lei, Xuan Yang, Hongyu Cai, Tao Jiang, Yuxuan Chen, Mingzu Dai, Zehua Yang
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引用次数: 0
Abstract
Five NNN type pincer-metal complexes NNN-CuCl2 (6a), (R,R)-NNN-CuCl2 (6b), NNN-NiCl2⋅H2O (6c), (R,R)-NNN-NiCl2⋅H2O (6d), and (R,R)-NNN-CoCl2 (6e) were synthesized in reasonable yield and characterized by HRMS, and/or single crystal X-ray diffractions. The ORTEP drawing of complexes 6b, 6e shows that the coordination geometry around the metal center is approximately square pyramidal. The cytotoxicities of these compounds were evaluated in vitro against K562, 293T, MCF-7, SiHa, and SH-SY5Y cell lines. The pharmacological results showed that most of the prepared compounds displayed good selective cytotoxicity toward K562 cells. Among them, compounds 6a and 6b possessed good anticancer activity against all cancer cells with less cell toxicity on 293T cells, even superior to cisplatin.
期刊介绍：
The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds.
Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome.
The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.
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