Emerging strategies for the treatment of endometriosis

Qiong Chen , Jing Wang , Xiaoya Ding , Qingfei Zhang , Ping Duan
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Abstract

Endometriosis is an estrogen-dependent disorder of the reproductive tract, affecting approximately 10 ​% of women. The symptoms of this condition are vague and not correlated with the disease's stage. These associated symptoms significantly impact women's overall well-being. The etiology of endometriosis remains inadequately understood, with coelomic metaplasia, lymphatic and vascular dissemination being regarded as additional hypotheses in addition to the retrograde menstruation theory. Endometriosis is primarily treated with drug therapy and surgical intervention, but the recurrence rate of symptoms after five years remains approximately 50 ​%. Therefore, the advancement of more effective and safe therapies for the treatment of endometriosis is of paramount importance. In this review, we introduce the utilization of photodynamic therapy, hyperthermia, gene therapy, immunotherapy, stem cell therapy, nanotechnology, and micron technology in the management of endometriosis. The objective is to provide novel research perspectives for therapeutic approaches and facilitate future clinical translation to enhance patient outcomes.

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治疗子宫内膜异位症的新策略
子宫内膜异位症是一种依赖雌激素的生殖道疾病,约有 10% 的妇女会患病。这种疾病的症状比较模糊,而且与疾病的阶段无关。这些相关症状严重影响了妇女的整体健康。人们对子宫内膜异位症的病因仍不十分清楚,除月经逆行理论外,还有一些其他的假说,如子宫内膜移行症、淋巴和血管播散等。子宫内膜异位症主要采用药物治疗和手术干预,但五年后症状复发率仍高达约 50%。因此,开发更有效、更安全的子宫内膜异位症治疗方法至关重要。在这篇综述中,我们将介绍光动力疗法、热疗、基因疗法、免疫疗法、干细胞疗法、纳米技术和微米技术在子宫内膜异位症治疗中的应用。目的是为治疗方法提供新的研究视角,并促进未来的临床转化,以提高患者的治疗效果。
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