Quercetin Attenuates Cancer-Associated Fibroblast Activation via Tumor-Stromal Interactions and Demonstrates Its Clinical Value in Pancreatic Cancer

IF 3.5 2区 农林科学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Food Biochemistry Pub Date : 2024-08-28 DOI:10.1155/2024/2177516
Defeng Lei, Yicui Piao, Tongning Zhong, Citing Zhang, Weipeng Ai, Yixing Kang, Haijun Ye, Biao Zheng, Jianhua Qu, Zilong Yan, Zhengquan Lai, Jikui Liu
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a rapidly progressing malignancy with a poor prognosis. Quercetin is a flavonoid compound with various biological benefits that can be extracted from Chinese herbs or daily foods. Quercetin has anticancer properties in various types of cancers. However, its therapeutic effects and potential mechanisms in PDAC have not been investigated extensively. Here, we confirmed the therapeutic effect of quercetin in PDAC using a mouse model. Based on high-throughput RNA sequencing (RNA-seq) and bioinformatic analysis, we propose that quercetin is involved in stromal infiltration of PDAC. Quercetin attenuates the activation of cancer-associated fibroblasts (CAFs) via tumor-stromal interaction. Meanwhile, we have identified two quercetin-related prognostic models for patients with PDAC. Finally, we proposed a downstream target of quercetin, the ITGB4 gene, which could be a potential therapeutic target for PDAC.

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槲皮素可通过肿瘤间质相互作用抑制癌症相关成纤维细胞的活化,并证明了其在胰腺癌中的临床价值
胰腺导管腺癌(PDAC)是一种进展迅速、预后不良的恶性肿瘤。槲皮素是从中草药或日常食物中提取的黄酮类化合物,具有多种生物功效。槲皮素对多种癌症具有抗癌作用。然而,它对 PDAC 的治疗效果和潜在机制尚未得到广泛研究。在此,我们利用小鼠模型证实了槲皮素对 PDAC 的治疗效果。基于高通量 RNA 测序(RNA-seq)和生物信息学分析,我们认为槲皮素参与了 PDAC 的基质浸润。槲皮素可通过肿瘤与基质之间的相互作用,抑制癌相关成纤维细胞(CAFs)的活化。同时,我们还发现了两种与槲皮素相关的 PDAC 患者预后模型。最后,我们提出了槲皮素的下游靶点--ITGB4基因,它可能成为PDAC的潜在治疗靶点。
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来源期刊
Journal of Food Biochemistry
Journal of Food Biochemistry 生物-生化与分子生物学
CiteScore
7.80
自引率
5.00%
发文量
488
审稿时长
3.6 months
期刊介绍: The Journal of Food Biochemistry publishes fully peer-reviewed original research and review papers on the effects of handling, storage, and processing on the biochemical aspects of food tissues, systems, and bioactive compounds in the diet. Researchers in food science, food technology, biochemistry, and nutrition, particularly based in academia and industry, will find much of great use and interest in the journal. Coverage includes: -Biochemistry of postharvest/postmortem and processing problems -Enzyme chemistry and technology -Membrane biology and chemistry -Cell biology -Biophysics -Genetic expression -Pharmacological properties of food ingredients with an emphasis on the content of bioactive ingredients in foods Examples of topics covered in recently-published papers on two topics of current wide interest, nutraceuticals/functional foods and postharvest/postmortem, include the following: -Bioactive compounds found in foods, such as chocolate and herbs, as they affect serum cholesterol, diabetes, hypertension, and heart disease -The mechanism of the ripening process in fruit -The biogenesis of flavor precursors in meat -How biochemical changes in farm-raised fish are affecting processing and edible quality
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