Relationship between Ikigai and longitudinal changes in serum HDL cholesterol levels: the Circulatory Risk in Communities Study (CIRCS).

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Lipids in Health and Disease Pub Date : 2024-08-28 DOI:10.1186/s12944-024-02256-0

Shiori Ikeda, Ai Ikeda, Kazumasa Yamagishi, Isao Muraki, Takumi Matsumura, Tomomi Kihara, Tomoko Sankai, Midori Takada, Takeo Okada, Masahiko Kiyama, Hironori Imano, Hiroyasu Iso, Takeshi Tanigawa

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Abstract

Background: Having positive psychological well-being has been associated with serum high-density lipoprotein cholesterol (HDLC), but no longitudinal study to date has examined the association between Ikigai and serum HDLC. Therefore, we examined the association between Ikigai and change in serum HDLC over time using a cohort dataset spanning 2010-2018.

Methods: The study included 471 men and 776 women aged 40-74 years who underwent a cardiovascular examination in 2010 and were asked their levels of Ikigai. We combined "definitely yes" and "yes" as "with Ikigai" and recorded "a little" as "with a little Ikigai" and "no" as "without Ikigai". We measured serum HDLC using direct methods. The association between Ikigai and serum HDLC levels at baseline, and changes in this relationship during an eight-year period, were analyzed using linear mixed-effect models.

Results: At the baseline, relative to those without Ikigai, women with Ikigai had higher serum HDLC (baseline difference in those with a little Ikigai = 7.52 mg/dl, 95% confidence interval [CI]: 1.12 to 13.9 and in those with Ikigai = 8.11 mg/dl, 95% CI: 1.54 to 14.7). The difference in serum HDLC between women with and without Ikigai remained over the eight-year follow-up period. There were no similar Ikigai-associated differences in the serum HDLC of men.

Conclusions: Women with Ikigai showed differences in serum HDLC that were observed at baseline and persisted over time.

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Ikigai 与血清高密度脂蛋白胆固醇水平纵向变化之间的关系：社区循环风险研究 (CIRCS)。

背景：积极的心理健康与血清高密度脂蛋白胆固醇（HDLC）有关，但迄今为止还没有纵向研究考察过Ikigai与血清HDLC之间的关系。因此，我们使用 2010-2018 年的队列数据集研究了 Ikigai 与血清高密度脂蛋白胆固醇随时间变化的关系：研究对象包括 471 名男性和 776 名女性，年龄在 40-74 岁之间，他们在 2010 年接受了心血管检查，并被问及 Ikigai 的水平。我们将 "肯定是 "和 "是 "合并为 "有 Ikigai"，将 "有一点 "记录为 "有一点 Ikigai"，将 "没有 "记录为 "没有 Ikigai"。我们采用直接方法测量血清高密度脂蛋白胆固醇。我们使用线性混合效应模型分析了基线 Ikigai 与血清高密度脂蛋白胆固醇水平之间的关系，以及八年间这种关系的变化：结果：与没有 Ikigai 的女性相比，有 Ikigai 的女性在基线时的血清高密度脂蛋白胆固醇水平较高（有少量 Ikigai 的女性的基线差异 = 7.52 mg/dl，95% 置信区间 [CI]：1.12 至 13.9；无 Ikigai 的女性的基线差异 = 7.52 mg/dl：1.12 至 13.9，Ikigai=8.11 mg/dl，95% 置信区间 [CI]：1.54 至 14.7）。在长达八年的随访期间，有 Ikigai 和没有 Ikigai 的女性之间的血清高密度脂蛋白胆固醇差异依然存在。男性血清高密度脂蛋白胆固醇与 Ikigai 没有类似的差异：结论：患有 Ikigai 的女性血清高密度脂蛋白胆固醇的差异在基线时就已观察到，并随着时间的推移而持续存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.