{"title":"Joint association of weekend catch-up sleep and triglyceride-glucose index on bone loss and all-cause mortality in employed U.S. adults aged 18-60 with diabetes.","authors":"Cong Ma, Jingcheng Li, Ronghui Yu, Junhong Li, Zhen'ai Liang, Kangwei Wang, Hongxiang Feng, Ping Liu, Xiaodong Wang, Yuxiong Weng","doi":"10.1186/s12944-026-02936-z","DOIUrl":"https://doi.org/10.1186/s12944-026-02936-z","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploration of the structural diversity and distribution pattern of gangliosides and sulfatides in mouse brain tissues and biomarkers for Parkinson's Disease.","authors":"Ming-Yang Liu, Juan Wang, Xiong-Yu Meng, Jia-Ru Liu, Xiao-Jun Yao, Yu-Wei Wang, Lee-Fong Yau, An-Ran Sun, Jia-Ning Mi, Liang Liu, Wen-Jing Ren, Yue Kang, Jing-Rong Wang","doi":"10.1186/s12944-026-02918-1","DOIUrl":"https://doi.org/10.1186/s12944-026-02918-1","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Residual cardiovascular risk persists in statin-treated patients with coronary artery disease (CAD), even when low-density lipoprotein cholesterol (LDL-C) targets are met. Excess apolipoprotein B (apoB), defined as measured apoB minus LDL-C-predicted apoB, may capture atherogenic particle burden beyond LDL-C, but its prognostic value for long-term mortality in secondary prevention remains uncertain.
Methods: We conducted a pooled analysis of two nationwide Chinese cohorts (CIN-II and RED-CARPET) comprising 68,616 statin-treated CAD patients. Excess apoB was calculated using an internal reference population (triglycerides ≤ 1.0 mmol/L). Associations with all-cause and cardiovascular mortality were assessed using multivariable Cox models, with adjustment for clinical covariates including nutritional status. External validation was performed in 13,702 participants from the UK Biobank.
Results: Over a median follow-up of 5.2 years, 10,835 deaths occurred (5,090 cardiovascular). Each 1-standard deviation (15.4 mg/dL) increase in excess apoB was associated with a 12% higher risk of all-cause mortality (adjusted hazard ratio [aHR] 1.12, 95% CI 1.06-1.18) and a 24% higher risk of cardiovascular mortality (aHR 1.24, 95% CI 1.15-1.34). Patients in the highest excess apoB quartile (≥ 11.5 mg/dL) had significantly worse survival. Notably, these associations persisted consistently across all achieved LDL-C strata (< 2.0 to > 4.0 mmol/L). These findings were robustly confirmed in the external validation cohort.
Conclusions: Excess apoB is an independent predictor of long-term mortality in statin-treated CAD patients, even among those with well-controlled LDL-C. Its incorporation into risk assessment could improve prognostic stratification and guide personalized management in secondary prevention.
Trial registration: CIN-II: ClinicalTrials.gov, NCT05050877 (Retrospectively registered, 21 September 2021); RED-CARPET: Chinese Clinical Trial Registry, ChiCTR2000039901 (Prospectively registered, 14 November 2020). The UK Biobank study is covered by generic ethical approval from the NHS National Research Ethics Service (Ref: 99231).
背景：即使低密度脂蛋白胆固醇（LDL-C）达标，他汀类药物治疗的冠状动脉疾病（CAD）患者仍存在残留的心血管风险。过量载脂蛋白B (apoB)，定义为测定的载脂蛋白B减去LDL-C预测的载脂蛋白B，可能捕获超过LDL-C的致动脉粥样硬化颗粒负担，但其在二级预防中对长期死亡率的预后价值仍不确定。方法：我们对两个全国性的中国队列（CIN-II和RED-CARPET）进行了汇总分析，其中包括68,616名他汀类药物治疗的CAD患者。使用内参人群（甘油三酯≤1.0 mmol/L）计算过量载脂蛋白ob。使用多变量Cox模型评估与全因死亡率和心血管死亡率的关联，并调整包括营养状况在内的临床协变量。外部验证在来自UK Biobank的13702名参与者中进行。结果：在中位随访5.2年期间，10,835人死亡（5,090人死于心血管疾病）。过量载脂蛋白每增加1个标准偏差（15.4 mg/dL），全因死亡风险增加12%（校正危险比[aHR] 1.12, 95% CI 1.06-1.18），心血管死亡风险增加24% （aHR 1.24, 95% CI 1.15-1.34）。最高过量载脂蛋白四分位数（≥11.5 mg/dL）的患者生存期明显较差。值得注意的是，这些关联在所有达到的LDL-C层（4.0 mmol/L）中都持续存在。这些发现在外部验证队列中得到了有力的证实。结论：过量载脂蛋白ob是他汀类药物治疗的冠心病患者长期死亡率的独立预测因子，即使在LDL-C控制良好的患者中也是如此。将其纳入风险评估可以改善预后分层，指导二级预防的个性化管理。试验注册：CIN-II: ClinicalTrials.gov, NCT05050877（回顾性注册，2021年9月21日）；红地毯：中国临床试验注册中心，ChiCTR2000039901（前瞻性注册，2020年11月14日）。英国生物银行的研究是由NHS国家研究伦理服务的通用伦理批准（参考：99231）。
{"title":"Excess apolipoprotein B predicts long-term survival in statin-treated CAD irrespective of achieved LDL-C levels: a pooled cohort analysis.","authors":"Wei Pan, Xiaozhao Lu, Ziwei Zhou, Jin Liu, Shaozhao Zhang, Haozhang Huang, Yibo He, Jingru Deng, Yihang Ling, Xianlin Ruan, Ling Jing, Weipeng Zhang, Shiqun Chen, Xinxue Liao, Jiyan Chen, Xiaodong Zhuang, Yong Liu","doi":"10.1186/s12944-026-02928-z","DOIUrl":"https://doi.org/10.1186/s12944-026-02928-z","url":null,"abstract":"<p><strong>Background: </strong>Residual cardiovascular risk persists in statin-treated patients with coronary artery disease (CAD), even when low-density lipoprotein cholesterol (LDL-C) targets are met. Excess apolipoprotein B (apoB), defined as measured apoB minus LDL-C-predicted apoB, may capture atherogenic particle burden beyond LDL-C, but its prognostic value for long-term mortality in secondary prevention remains uncertain.</p><p><strong>Methods: </strong>We conducted a pooled analysis of two nationwide Chinese cohorts (CIN-II and RED-CARPET) comprising 68,616 statin-treated CAD patients. Excess apoB was calculated using an internal reference population (triglycerides ≤ 1.0 mmol/L). Associations with all-cause and cardiovascular mortality were assessed using multivariable Cox models, with adjustment for clinical covariates including nutritional status. External validation was performed in 13,702 participants from the UK Biobank.</p><p><strong>Results: </strong>Over a median follow-up of 5.2 years, 10,835 deaths occurred (5,090 cardiovascular). Each 1-standard deviation (15.4 mg/dL) increase in excess apoB was associated with a 12% higher risk of all-cause mortality (adjusted hazard ratio [aHR] 1.12, 95% CI 1.06-1.18) and a 24% higher risk of cardiovascular mortality (aHR 1.24, 95% CI 1.15-1.34). Patients in the highest excess apoB quartile (≥ 11.5 mg/dL) had significantly worse survival. Notably, these associations persisted consistently across all achieved LDL-C strata (< 2.0 to > 4.0 mmol/L). These findings were robustly confirmed in the external validation cohort.</p><p><strong>Conclusions: </strong>Excess apoB is an independent predictor of long-term mortality in statin-treated CAD patients, even among those with well-controlled LDL-C. Its incorporation into risk assessment could improve prognostic stratification and guide personalized management in secondary prevention.</p><p><strong>Trial registration: </strong>CIN-II: ClinicalTrials.gov, NCT05050877 (Retrospectively registered, 21 September 2021); RED-CARPET: Chinese Clinical Trial Registry, ChiCTR2000039901 (Prospectively registered, 14 November 2020). The UK Biobank study is covered by generic ethical approval from the NHS National Research Ethics Service (Ref: 99231).</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-19DOI: 10.1186/s12944-026-02930-5
Elvire N Landstra, Valerie Lohner, Juliana F Tavares, Kersten Diers, Alexandra Koch, Monique M B Breteler
{"title":"Plasma complex lipids in relation to cortical thickness and brain volumes: results from the population-based Rhineland study.","authors":"Elvire N Landstra, Valerie Lohner, Juliana F Tavares, Kersten Diers, Alexandra Koch, Monique M B Breteler","doi":"10.1186/s12944-026-02930-5","DOIUrl":"https://doi.org/10.1186/s12944-026-02930-5","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-19DOI: 10.1186/s12944-026-02932-3
Xinran Wang, Sirun Qin, Hong Xiang, Ye Tao, Shuhua Chen, Hongwei Lu
{"title":"Association of the atherogenic index of plasma combined with obesity indices with cardiovascular disease and mortality.","authors":"Xinran Wang, Sirun Qin, Hong Xiang, Ye Tao, Shuhua Chen, Hongwei Lu","doi":"10.1186/s12944-026-02932-3","DOIUrl":"https://doi.org/10.1186/s12944-026-02932-3","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SdLDL‑C/LDL‑C discordance as a practical surrogate for triglyceride‑associated cardiovascular risk: identification of at‑risk lipid phenotypes in the CHARLS prospective cohort.","authors":"Yaya Xue, Jing Luo, Xinyu Yang, Zhaoyu Ren, Hongxuan Fan, Wei Luo, Bin Liang","doi":"10.1186/s12944-026-02925-2","DOIUrl":"https://doi.org/10.1186/s12944-026-02925-2","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1186/s12944-026-02922-5
Tania Guillemette, David Rhainds, Océane Robert, Catherine Mounier
{"title":"Exploring sex bias in cardiometabolic diseases.","authors":"Tania Guillemette, David Rhainds, Océane Robert, Catherine Mounier","doi":"10.1186/s12944-026-02922-5","DOIUrl":"https://doi.org/10.1186/s12944-026-02922-5","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1186/s12944-026-02917-2
Igor Oliveira, Andreas Elias Gilpin-Falk, Robert C Block
{"title":"Hypothesis: the rs66698963 insertion-deletion alters the AA/EPA ratio and cardiovascular disease risk.","authors":"Igor Oliveira, Andreas Elias Gilpin-Falk, Robert C Block","doi":"10.1186/s12944-026-02917-2","DOIUrl":"https://doi.org/10.1186/s12944-026-02917-2","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1186/s12944-026-02903-8
Fangqu Liu, Yan Li, Bingxuan Kong, Chanhua Liang, Li Chen, Jingfan Xiong, Xiu Zhao, Zhe Su, Pei Xiao, Jie Mi, Ping Yao, Yuhan Tang, Yanyan Li
{"title":"Exposure to phthalate and phenol mixtures and obesity in children and adolescents: the dominant role of bisphenol A.","authors":"Fangqu Liu, Yan Li, Bingxuan Kong, Chanhua Liang, Li Chen, Jingfan Xiong, Xiu Zhao, Zhe Su, Pei Xiao, Jie Mi, Ping Yao, Yuhan Tang, Yanyan Li","doi":"10.1186/s12944-026-02903-8","DOIUrl":"https://doi.org/10.1186/s12944-026-02903-8","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-16DOI: 10.1186/s12944-026-02919-0
Xiaoxue Zhang, Qing Xu, Yan Chenxi, Huan Wang, Mei Zhizun, Min Hu, Cai Cheng, Yi Bian, Shiliang Li
{"title":"Unmasking silent bioenergetic failure in normolactatemic AMI patients: a multicenter validation of the TyG-ACAG index.","authors":"Xiaoxue Zhang, Qing Xu, Yan Chenxi, Huan Wang, Mei Zhizun, Min Hu, Cai Cheng, Yi Bian, Shiliang Li","doi":"10.1186/s12944-026-02919-0","DOIUrl":"https://doi.org/10.1186/s12944-026-02919-0","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号