Correlation between body composition and bone mineral density differs by sex and skeletal site in overweight and obese Chinese subjects

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-08-23 DOI:10.1016/j.jocd.2024.101526

Xiang Chen , Yanhong Guo , Fangli Zhou , Xi Wang , Suyuan Wang , Chenghui Zhang , Mingxia Li , Yunhong Wu

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Abstract

Previous studies have yielded inconsistent results regarding the relationship between obesity and bone mineral density (BMD). The aim of this study was to determine the influence of body composition on BMD and the serum sclerostin level in overweight and obese adults. The study had a cross-sectional design and included 90 men and 118 women with a body mass index ≥25. Fat mass, lean mass, and spinal and pelvic BMD were measured using dual-emission X-ray absorptiometry. Subcutaneous fat, visceral fat, and lean mass were measured between L2 and L3 by 16-slice spiral computed tomography. The serum sclerostin level was determined by enzyme-linked immunosorbent assay. Pearson analysis showed that fat mass and appendicular lean mass were positively correlated with spinal BMD in both sexes. A positive association of both fat mass and lean mass with pelvic BMD, which was stronger in women, was also found. Partial correlation analysis showed the positive association between fat mass and BMD was significantly attenuated but the positive association between lean mass and pelvic BMD remained after adjustment for age and body weight. A negative correlation was observed between visceral fat and spinal and pelvic BMD only in women, and the positive association between lean mass with pelvic BMD was more obvious in women than in men, indicating body composition seemed to have a greater impact on the BMD in women. The serum sclerostin level was positively associated with BMD but not with body composition. These findings suggest that the correlation between body composition and BMD is influenced by sex and skeletal site.

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超重和肥胖中国受试者的身体成分与骨矿物质密度之间的相关性因性别和骨骼部位而异

关于肥胖与骨矿物质密度（BMD）之间的关系，以往的研究结果并不一致。本研究旨在确定身体成分对超重和肥胖成年人骨密度和血清硬骨素水平的影响。研究采用横断面设计，包括体重指数≥25 的 90 名男性和 118 名女性。使用双发射 X 射线吸收测量法测量了脂肪量、瘦肉量、脊柱和骨盆 BMD。通过 16 片螺旋计算机断层扫描测量了 L2 和 L3 之间的皮下脂肪、内脏脂肪和瘦体重。通过酶联免疫吸附试验测定了血清硬骨素水平。皮尔逊分析表明，男性和女性的脂肪量和阑尾瘦肉量与脊柱 BMD 呈正相关。脂肪量和瘦体重与骨盆 BMD 也呈正相关，女性的相关性更强。部分相关分析表明，在调整年龄和体重后，脂肪量与 BMD 之间的正相关性明显减弱，但瘦体重与骨盆 BMD 之间的正相关性依然存在。只有女性的内脏脂肪与脊柱和骨盆 BMD 之间呈负相关，而女性的瘦体重与骨盆 BMD 之间的正相关比男性更明显，这表明身体成分似乎对女性的 BMD 影响更大。血清硬骨生成素水平与 BMD 呈正相关，但与身体成分无关。这些研究结果表明，身体成分与 BMD 之间的相关性受性别和骨骼部位的影响。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.