Pub Date : 2025-04-04DOI: 10.1016/j.jocd.2025.101586
Ibrahim Fayad , Antonio Pinti , Hassane Zouhal , Rawad El Hage
The aim of the current study was to explore the relationships between 20-meter sprinting time and composite indices of femoral neck strength (compression strength index (CSI), bending strength index (BSI) and impact strength index (ISI)) in a group of middle-aged active men. 50 middle-aged active men voluntarily participated in this study. Their mean age was 45 ± 8.6 years. Body composition, total hip bone mineral density (TH BMD) and femoral neck bone mineral density (FN BMD) were evaluated by DXA. Sprinting time was negatively correlated to CSI (r = −0.52; p < 0.001), BSI (r = −0.43; p < 0.01) and ISI (r = −0.47; p < 0.001). The significant correlations between sprinting time and composite indices of femoral neck strength (CSI, BSI and ISI) remained significant after controlling for body weight, age and maximum oxygen consumption using multiple linear regressions. In conclusion, the current study suggests that sprinting performance (m/sec) is a positive determinant of CSI, BSI and ISI in middle-aged men.
{"title":"Sprinting performance correlates with composite indices of femoral neck strength in middle-aged active men","authors":"Ibrahim Fayad , Antonio Pinti , Hassane Zouhal , Rawad El Hage","doi":"10.1016/j.jocd.2025.101586","DOIUrl":"10.1016/j.jocd.2025.101586","url":null,"abstract":"<div><div>The aim of the current study was to explore the relationships between 20-meter sprinting time and composite indices of femoral neck strength (compression strength index (CSI), bending strength index (BSI) and impact strength index (ISI)) in a group of middle-aged active men. 50 middle-aged active men voluntarily participated in this study. Their mean age was 45 ± 8.6 years. Body composition, total hip bone mineral density (TH BMD) and femoral neck bone mineral density (FN BMD) were evaluated by DXA. Sprinting time was negatively correlated to CSI (<em>r</em> = −0.52; <em>p</em> < 0.001), BSI (<em>r</em> = −0.43; <em>p</em> < 0.01) and ISI (<em>r</em> = −0.47; <em>p</em> < 0.001). The significant correlations between sprinting time and composite indices of femoral neck strength (CSI, BSI and ISI) remained significant after controlling for body weight, age and maximum oxygen consumption using multiple linear regressions. In conclusion, the current study suggests that sprinting performance (m/sec) is a positive determinant of CSI, BSI and ISI in middle-aged men.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 3","pages":"Article 101586"},"PeriodicalIF":1.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.jocd.2025.101584
Askeri Türken , Haşim Çapar
Purpose/introduction: The aim of this study was to determine which method can determine bone mineral changes in patients with Myotonic Dystrophy at an early age by applying age classification and Modified Rankin Scale for Neurological Disability (MRSND).
Methods: This descriptive, cross-sectional and retrospective study was conducted in 52 myopathy patients diagnosed with myotonic dystrophy. Analyses were performed using SPSS 25 and STATA 14. Frequency and percentage, mean and standard deviation values were reported and Pearson correlation, t-test, ANOVA and multiple linear regression analyses were performed. Confidence levels of 0.10, 0.05 and 0.01. The study complies with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement guidelines for reporting cross-sectional studies (STROBE CHECKLIST).
Results: According to the regression analysis results, body mass index had a positive effect on Femoral Z Score (p < 0.01). In addition, vitamin D had a positive effect on Femoral Z Score (p < 0.05). On the other hand, MRSND had a negative effect on Femoral Z Score (p < 0.01).
Conclusion: Myotonic dystrophic myopathy has been shown to impair the mineral structure of bone. Patients with this condition have been shown to recognize possible changes in their bones earlier in using the MRSND scale.
{"title":"Analysis of Changes in Bone Mineral Density by Disability Level in Patients with Myotonic Dystrophy Myopathy","authors":"Askeri Türken , Haşim Çapar","doi":"10.1016/j.jocd.2025.101584","DOIUrl":"10.1016/j.jocd.2025.101584","url":null,"abstract":"<div><div><em>Purpose/introduction:</em> The aim of this study was to determine which method can determine bone mineral changes in patients with Myotonic Dystrophy at an early age by applying age classification and Modified Rankin Scale for Neurological Disability (MRSND).</div><div><em>Methods:</em> This descriptive, cross-sectional and retrospective study was conducted in 52 myopathy patients diagnosed with myotonic dystrophy. Analyses were performed using SPSS 25 and STATA 14. Frequency and percentage, mean and standard deviation values were reported and Pearson correlation, t-test, ANOVA and multiple linear regression analyses were performed. Confidence levels of 0.10, 0.05 and 0.01. The study complies with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement guidelines for reporting cross-sectional studies (STROBE CHECKLIST).</div><div><em>Results:</em> According to the regression analysis results, body mass index had a positive effect on Femoral Z Score (<em>p</em> < 0.01). In addition, vitamin D had a positive effect on Femoral Z Score (<em>p</em> < 0.05). On the other hand, MRSND had a negative effect on Femoral Z Score (<em>p</em> < 0.01).</div><div><em>Conclusion:</em> Myotonic dystrophic myopathy has been shown to impair the mineral structure of bone. Patients with this condition have been shown to recognize possible changes in their bones earlier in using the MRSND scale.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 2","pages":"Article 101584"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-26DOI: 10.1016/j.jocd.2025.101585
Yong-Chan Ha , Shinjune Kim , Jun-Il Yoo
Background: Sarcopenia, the age-related loss of muscle mass, increases health risks in older adults. Accurate measurement of skeletal muscle mass is critical for diagnosis. While DEXA is widely used, its extended scan time limits clinical utility. This study evaluates the accuracy of lean mass measurements from the newly developed iNSiGHT C510 X-ray bone densitometer compared to MRI, the gold standard.
Methods: This single-center, open-label clinical trial included 20 adult participants (10 males, 10 females) aged 20–70 years. Participants underwent whole-body scans using the iNSiGHT C510 and MRI. Lean and fat mass measurements were obtained from both devices. Statistical analysis included Bland-Altman plots, intraclass correlation coefficients (ICC), and concordance correlation coefficients (CCC) to assess agreement between the two methods. Linear regression analysis was performed to derive conversion formulas between C510 and MRI measurements.
Results: The study found a very strong correlation between lean mass measurements from the iNSiGHT C510 and MRI, with correlation coefficients (r) of 0.961 for the right side, 0.967 for the left, and 0.963 for combined lean mass. ICC and CCC values for lean mass were also high, indicating strong agreement between the two methods. Fat mass measurements, though moderately correlated, showed larger discrepancies compared to lean mass. The iNSiGHT C510 significantly reduced measurement time by 50 % compared to conventional DEXA scans.
Conclusion: The iNSiGHT C510 demonstrated high accuracy in measuring lean mass compared to MRI, with the added benefit of shorter measurement time, making it a practical tool for sarcopenia diagnosis and monitoring in clinical settings. However, further research with larger sample sizes and long-term assessments is needed to validate its broader clinical utility.
{"title":"Correlation of Lean Mass Measurements Between a Novel Whole-body X-ray Bone Densitometer (iNSiGHT C510) and Magnetic Resonance Imaging: A Single-center Comparative study","authors":"Yong-Chan Ha , Shinjune Kim , Jun-Il Yoo","doi":"10.1016/j.jocd.2025.101585","DOIUrl":"10.1016/j.jocd.2025.101585","url":null,"abstract":"<div><div><em>Background:</em> Sarcopenia, the age-related loss of muscle mass, increases health risks in older adults. Accurate measurement of skeletal muscle mass is critical for diagnosis. While DEXA is widely used, its extended scan time limits clinical utility. This study evaluates the accuracy of lean mass measurements from the newly developed iNSiGHT C510 X-ray bone densitometer compared to MRI, the gold standard.</div><div><em>Methods:</em> This single-center, open-label clinical trial included 20 adult participants (10 males, 10 females) aged 20–70 years. Participants underwent whole-body scans using the iNSiGHT C510 and MRI. Lean and fat mass measurements were obtained from both devices. Statistical analysis included Bland-Altman plots, intraclass correlation coefficients (ICC), and concordance correlation coefficients (CCC) to assess agreement between the two methods. Linear regression analysis was performed to derive conversion formulas between C510 and MRI measurements.</div><div><em>Results:</em> The study found a very strong correlation between lean mass measurements from the iNSiGHT C510 and MRI, with correlation coefficients (r) of 0.961 for the right side, 0.967 for the left, and 0.963 for combined lean mass. ICC and CCC values for lean mass were also high, indicating strong agreement between the two methods. Fat mass measurements, though moderately correlated, showed larger discrepancies compared to lean mass. The iNSiGHT C510 significantly reduced measurement time by 50 % compared to conventional DEXA scans.</div><div><em>Conclusion:</em> The iNSiGHT C510 demonstrated high accuracy in measuring lean mass compared to MRI, with the added benefit of shorter measurement time, making it a practical tool for sarcopenia diagnosis and monitoring in clinical settings. However, further research with larger sample sizes and long-term assessments is needed to validate its broader clinical utility.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 3","pages":"Article 101585"},"PeriodicalIF":1.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-22DOI: 10.1016/j.jocd.2025.101583
Hoc Nguyen Van , Khanh Nguyen Manh , Hoang Le Xuan
Objectives: After total knee arthroplasty (TKA), bone structure changes around prosthetics gradually appear. Adverse changes, such as decreased bone mineral density (BMD) and bone remodeling, can lead to joint loosening, affecting surgical outcomes. The study aims to detect BMD changes in the bone around the artificial knee early after TKA.
Methods: We performed a prospectively descriptive study on 54 patients who were operated at Viet Duc University Hospital from 4/2017 to 4/2019. Bone density was measured using dual-energy X-ray absorptiometry (DEXA) at the seventh days, 3,6,12, and 24 months post-surgery.
Results: The BMD in the medial metaphyseal region of interest decreased by 10.36 %, 11.5 %, 11.88 %, and 12.13 % at 3, 6, 12, and 24 months respectively, compared to 7 days post-surgery. The lateral metaphyseal region of interest decreased by 6.09 %, 6.47 %, 6.97 %, and 7.1 % and the tibial diaphyseal region of interest decreased by 3.75 %, 4.66 %, 5.91 %, and 5.8 % over the same follow-up periods. The BMD in the femoral condyle region of interest decreased by 8.15 %, 8.62 %, 9.24 %, and 10.65 % compared to the corresponding 7-day period at 3,6,12, and 24 months post-surgery.
Conclusion: The periprosthetic BMD rapidly reduced in the first 3 months, then gradually decreased. After 24 months of follow-up, the BMD in the medial metaphyseal region of interest decreased the most.
{"title":"Periprosthetic Bone Mineral Density Change after Total Knee Arthroplasty in Vietnamese Population","authors":"Hoc Nguyen Van , Khanh Nguyen Manh , Hoang Le Xuan","doi":"10.1016/j.jocd.2025.101583","DOIUrl":"10.1016/j.jocd.2025.101583","url":null,"abstract":"<div><div><em>Objectives:</em> After total knee arthroplasty (TKA), bone structure changes around prosthetics gradually appear. Adverse changes, such as decreased bone mineral density (BMD) and bone remodeling, can lead to joint loosening, affecting surgical outcomes. The study aims to detect BMD changes in the bone around the artificial knee early after TKA.</div><div><em>Methods:</em> We performed a prospectively descriptive study on 54 patients who were operated at Viet Duc University Hospital from 4/2017 to 4/2019. Bone density was measured using dual-energy X-ray absorptiometry (DEXA) at the seventh days, 3,6,12, and 24 months post-surgery.</div><div><em>Results:</em> The BMD in the medial metaphyseal region of interest decreased by 10.36 %, 11.5 %, 11.88 %, and 12.13 % at 3, 6, 12, and 24 months respectively, compared to 7 days post-surgery. The lateral metaphyseal region of interest decreased by 6.09 %, 6.47 %, 6.97 %, and 7.1 % and the tibial diaphyseal region of interest decreased by 3.75 %, 4.66 %, 5.91 %, and 5.8 % over the same follow-up periods. The BMD in the femoral condyle region of interest decreased by 8.15 %, 8.62 %, 9.24 %, and 10.65 % compared to the corresponding 7-day period at 3,6,12, and 24 months post-surgery.</div><div><em>Conclusion:</em> The periprosthetic BMD rapidly reduced in the first 3 months, then gradually decreased. After 24 months of follow-up, the BMD in the medial metaphyseal region of interest decreased the most.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 3","pages":"Article 101583"},"PeriodicalIF":1.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-19DOI: 10.1016/j.jocd.2025.101578
Ahdad Ziyar , Alexander Bolufer , Emily Littman , Shazia Beg
Introduction: Osteoporosis represents a preventable and often treatable condition that is responsible for 1.5 million fractures annually in the United States. Proper patient knowledge represents a crucial aspect of disease management and has potential implications in treatment adherence and lifestyle modification. By examining how much patients know about their own diagnosis, their disease knowledge, and what resources they would like to use, we aim to lay the groundwork for developing efficient patient education resources. Methodology: We surveyed 52 individuals and collected data on demographics, bone density test results, disease knowledge, and educational sources both used and preferred. This was done to learn how much patients know about their condition on a fundamental level. Results: 50% of participants diagnosed with osteoporosis correctly self-reported their condition, as did 21.1% diagnosed with osteopenia. Between the normal, osteopenia, and osteoporosis groups there were no significant differences between participants’ scores on the patient knowledge questionnaire. The resources most used by patients were handouts/brochures and internet/personal research, and patients reported a preference for learning directly from their doctor/nurse. Conclusion: Osteoporosis is associated with millions of fragility fractures occurring annually worldwide. Our study showed a consistent level of knowledge across patients with normal bone mineral density, osteopenia, and osteoporosis, suggesting the need for targeted education efforts, particularly for those with severe forms of the disease. We confirmed the invaluable role of medical personnel in teaching patients about bone density loss. It is through efficient learning that patients can be empowered to take charge of their health.
{"title":"An Examination of Patient Knowledge and Education in Patients with Osteoporosis, Osteopenia, and Normal Bone Density","authors":"Ahdad Ziyar , Alexander Bolufer , Emily Littman , Shazia Beg","doi":"10.1016/j.jocd.2025.101578","DOIUrl":"10.1016/j.jocd.2025.101578","url":null,"abstract":"<div><div><em>Introduction:</em> Osteoporosis represents a preventable and often treatable condition that is responsible for 1.5 million fractures annually in the United States. Proper patient knowledge represents a crucial aspect of disease management and has potential implications in treatment adherence and lifestyle modification. By examining how much patients know about their own diagnosis, their disease knowledge, and what resources they would like to use, we aim to lay the groundwork for developing efficient patient education resources. <em>Methodology:</em> We surveyed 52 individuals and collected data on demographics, bone density test results, disease knowledge, and educational sources both used and preferred. This was done to learn how much patients know about their condition on a fundamental level. <em>Results:</em> 50% of participants diagnosed with osteoporosis correctly self-reported their condition, as did 21.1% diagnosed with osteopenia. Between the normal, osteopenia, and osteoporosis groups there were no significant differences between participants’ scores on the patient knowledge questionnaire. The resources most used by patients were handouts/brochures and internet/personal research, and patients reported a preference for learning directly from their doctor/nurse. <em>Conclusion:</em> Osteoporosis is associated with millions of fragility fractures occurring annually worldwide. Our study showed a consistent level of knowledge across patients with normal bone mineral density, osteopenia, and osteoporosis, suggesting the need for targeted education efforts, particularly for those with severe forms of the disease. We confirmed the invaluable role of medical personnel in teaching patients about bone density loss. It is through efficient learning that patients can be empowered to take charge of their health.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 3","pages":"Article 101578"},"PeriodicalIF":1.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-11DOI: 10.1016/j.jocd.2025.101581
Xin'e Zhong , Liyun Li , Weiliang Wan
Objective: To evaluate the efficacy and safety of different kidney-tonifying Chinese medicines (KTCMs) combined with bisphosphonates (BPs) in postmenopausal osteoporosis (PMOP) patients.
Methods: This study included 15 randomized controlled trials (RCTs) involving a total of 1,360 PMOP patients to compare the efficacy and safety of various KTCMs combined with BPs. A systematic search was conducted in eight medical databases (CNKI, PUBMED, Web of Science, Cochrane, EMBASE, Wanfang, VIP, and TCM Online). The inclusion criteria were as follows: (1) participants were postmenopausal women with PMOP; (2) the intervention involved different KTCMs combined with BPs; (3) outcome measures included pain Visual Analog Scale (VAS) scores, lumbar spine bone mineral density (BMD), femoral neck BMD, serum osteocalcin levels, and the incidence of adverse events. A network meta-analysis was performed to integrate data, calculating mean differences (MD) with 95 % confidence intervals (CIs). SUCRA values were used to rank treatment efficacy and assess the relative advantages of different regimens. League tables were used to visually present direct and indirect comparisons of treatments, while funnel plots were used to evaluate publication bias. The quality of the included studies was assessed using the Cochrane risk-of-bias tool.
Results: GSK + BPs and JWEX + BPs were the most effective in pain relief, while GSK + BPs showed the best efficacy in improving lumbar spine and femoral neck BMD. LWDH + BPs demonstrated superior performance in promoting bone metabolism. Safety analysis indicated a low incidence of adverse events, with no statistically significant difference between the experimental and control groups (p > 0.05).
Conclusion: This study suggests that GSK + BPs and JWEX + BPs are the most effective combinations for pain relief and BMD improvement, while LWDH + BPs and GSK + BPs have advantages in promoting bone metabolism. The combination of KTCMs with BPs can effectively improve PMOP with high safety, offering significant clinical value.
{"title":"Optimal kidney-tonifying traditional chinese medicines for postmenopausal osteoporosis: A network meta-analysis of randomized controlled trials","authors":"Xin'e Zhong , Liyun Li , Weiliang Wan","doi":"10.1016/j.jocd.2025.101581","DOIUrl":"10.1016/j.jocd.2025.101581","url":null,"abstract":"<div><div><em>Objective:</em> To evaluate the efficacy and safety of different kidney-tonifying Chinese medicines (KTCMs) combined with bisphosphonates (BPs) in postmenopausal osteoporosis (PMOP) patients.</div><div><em>Methods:</em> This study included 15 randomized controlled trials (RCTs) involving a total of 1,360 PMOP patients to compare the efficacy and safety of various KTCMs combined with BPs. A systematic search was conducted in eight medical databases (CNKI, PUBMED, Web of Science, Cochrane, EMBASE, Wanfang, VIP, and TCM Online). The inclusion criteria were as follows: (1) participants were postmenopausal women with PMOP; (2) the intervention involved different KTCMs combined with BPs; (3) outcome measures included pain Visual Analog Scale (VAS) scores, lumbar spine bone mineral density (BMD), femoral neck BMD, serum osteocalcin levels, and the incidence of adverse events. A network meta-analysis was performed to integrate data, calculating mean differences (MD) with 95 % confidence intervals (CIs). SUCRA values were used to rank treatment efficacy and assess the relative advantages of different regimens. League tables were used to visually present direct and indirect comparisons of treatments, while funnel plots were used to evaluate publication bias. The quality of the included studies was assessed using the Cochrane risk-of-bias tool.</div><div><em>Results:</em> GSK + BPs and JWEX + BPs were the most effective in pain relief, while GSK + BPs showed the best efficacy in improving lumbar spine and femoral neck BMD. LWDH + BPs demonstrated superior performance in promoting bone metabolism. Safety analysis indicated a low incidence of adverse events, with no statistically significant difference between the experimental and control groups (<em>p</em> > 0.05).</div><div><em>Conclusion:</em> This study suggests that GSK + BPs and JWEX + BPs are the most effective combinations for pain relief and BMD improvement, while LWDH + BPs and GSK + BPs have advantages in promoting bone metabolism. The combination of KTCMs with BPs can effectively improve PMOP with high safety, offering significant clinical value.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 2","pages":"Article 101581"},"PeriodicalIF":1.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-10DOI: 10.1016/j.jocd.2025.101582
Mina Ebrahimiarjestan , Miriam O'sullivan , Attracta Brennan , Erjiang E , Bryan Whelan , Lan Yang , Tingyan Wang , Carmel Silke , Ming Yu , Mary Dempsey , John J. Carey
DXA technology is widely available today in many regions of the world. There is a growing realization of the value of DXA not only for osteoporosis management but also for sports medicine, sarcopenia, and the assessment of cardiovascular disease and mortality. Such features may be of particular interest for populations with a greater risk of these outcomes such as those with diabetes mellitus or rheumatoid arthritis. Recent systematic reviews and meta-analyses show DXA can robustly predict fractures, cardiovascular disease, dementia and mortality. Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting multiple organs including synovial joints, bone and other tissues. People suffering from RA have a greater propensity to osteoporotic fracture, cardiovascular disease, infection and premature death, which is well recognised. RA is the only unique disease included in some fracture risk algorithms such as FRAX, and so RA patients are often referred for a DXA scan to evaluate their risk of osteoporosis. We have previously shown vertebral fractures, aortic calcification and cardiovascular disease are prevalent in our RA population, with strong association. In this paper we performed a scoping review of published literature in Medline and Embase to better understand the current status of DXA and cardiovascular disease in RA populations. 822 papers were identified in an initial search of which 7 papers reflecting 2,038 RA patients from 7 different countries were included. Study design included 4 cross-sectional, 2 longitudinal and 1 case-control. All included associations with various cardiovascular measures, while only 1 included clinical events as an outcome. Our results suggest this is an area which remains relatively unexplored but has substantial important clinical potential.
{"title":"DXA and cardiovascular disease in rheumatoid arthritis: A scoping review","authors":"Mina Ebrahimiarjestan , Miriam O'sullivan , Attracta Brennan , Erjiang E , Bryan Whelan , Lan Yang , Tingyan Wang , Carmel Silke , Ming Yu , Mary Dempsey , John J. Carey","doi":"10.1016/j.jocd.2025.101582","DOIUrl":"10.1016/j.jocd.2025.101582","url":null,"abstract":"<div><div>DXA technology is widely available today in many regions of the world. There is a growing realization of the value of DXA not only for osteoporosis management but also for sports medicine, sarcopenia, and the assessment of cardiovascular disease and mortality. Such features may be of particular interest for populations with a greater risk of these outcomes such as those with diabetes mellitus or rheumatoid arthritis. Recent systematic reviews and meta-analyses show DXA can robustly predict fractures, cardiovascular disease, dementia and mortality. Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting multiple organs including synovial joints, bone and other tissues. People suffering from RA have a greater propensity to osteoporotic fracture, cardiovascular disease, infection and premature death, which is well recognised. RA is the only unique disease included in some fracture risk algorithms such as FRAX, and so RA patients are often referred for a DXA scan to evaluate their risk of osteoporosis. We have previously shown vertebral fractures, aortic calcification and cardiovascular disease are prevalent in our RA population, with strong association. In this paper we performed a scoping review of published literature in Medline and Embase to better understand the current status of DXA and cardiovascular disease in RA populations. 822 papers were identified in an initial search of which 7 papers reflecting 2,038 RA patients from 7 different countries were included. Study design included 4 cross-sectional, 2 longitudinal and 1 case-control. All included associations with various cardiovascular measures, while only 1 included clinical events as an outcome. Our results suggest this is an area which remains relatively unexplored but has substantial important clinical potential.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 2","pages":"Article 101582"},"PeriodicalIF":1.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-10DOI: 10.1016/j.jocd.2025.101580
Mohammad Reza Foroutani , Mohammad Reza Salamat , Sakineh Bagherzadeh , Mohammad Keshtkar , Mehri Khoshhali , Mahdi Asgari
Background: The aim of this study was to investigate the differential effects of trunk region body composition—specifically fat mass (FM) and lean mass (LM)—on lumbar spine bone mineral density (BMD) and bone mineral content (BMC), with a focus on variations by gender and menopausal status.
Materials and Methods: We identified 331 adult patients (69 men, 161 premenopausal women, and 101 postmenopausal women) who underwent dual-energy X-ray absorptiometry (DXA) to simultaneously measure trunk body composition and lumbar spine BMD (L2-L4). The Pearson correlation coefficient was used to assess the linear relationships between body composition components and lumbar spine BMD and BMC, stratified by gender and menopausal status. Additionally, multiple linear regression analysis with the forward stepwise elimination procedure was applied to find a reasonable subset of predictor variables.
Result: The highest correlation coefficients between body composition and BMD were seen for men and post- and premenopausal individuals in the following areas: pelvic fat mass (r = 0.325; P < 0.01), chest lean mass (r = 0.260; P < 0.01), and total lean mass (r = 0.312; P < 0.01), respectively. Additionally, total lean mass (r = 0.477; P < 0.01), chest lean mass (r = 0.360; P < 0.01), and total lean mass (r = 0.459; P < 0.01) had the strongest correlation coefficients between body composition and BMC. Forward stepwise regression identified age, chest lean mass, and midriff fat mass as predictors of BMC in postmenopausal women; BMI and total lean mass in premenopausal women; and total lean mass in men. For BMD, chest lean mass (postmenopausal), total lean mass (premenopausal), and BMI (men) were significant predictors.
Conclusions: Fat mass does not affect BMD or BMC, while lean mass, strongly predicts bone health. Trunk body composition showed varying relationships with BMD and BMC, making it challenging to pinpoint how lean mass distribution in the chest and midriff specifically impacts bone health.
{"title":"The role of trunk region body composition in lumbar spine bone mineral content and density","authors":"Mohammad Reza Foroutani , Mohammad Reza Salamat , Sakineh Bagherzadeh , Mohammad Keshtkar , Mehri Khoshhali , Mahdi Asgari","doi":"10.1016/j.jocd.2025.101580","DOIUrl":"10.1016/j.jocd.2025.101580","url":null,"abstract":"<div><div><em>Background:</em> The aim of this study was to investigate the differential effects of trunk region body composition—specifically fat mass (FM) and lean mass (LM)—on lumbar spine bone mineral density (BMD) and bone mineral content (BMC), with a focus on variations by gender and menopausal status.</div><div><em>Materials and Methods:</em> We identified 331 adult patients (69 men, 161 premenopausal women, and 101 postmenopausal women) who underwent dual-energy X-ray absorptiometry (DXA) to simultaneously measure trunk body composition and lumbar spine BMD (L<sub>2</sub>-L<sub>4</sub>). The Pearson correlation coefficient was used to assess the linear relationships between body composition components and lumbar spine BMD and BMC, stratified by gender and menopausal status. Additionally, multiple linear regression analysis with the forward stepwise elimination procedure was applied to find a reasonable subset of predictor variables.</div><div><em>Result:</em> The highest correlation coefficients between body composition and BMD were seen for men and post- and premenopausal individuals in the following areas: pelvic fat mass (<em>r</em> = 0.325; <em>P</em> < 0.01), chest lean mass (<em>r</em> = 0.260; <em>P</em> < 0.01), and total lean mass (<em>r</em> = 0.312; <em>P</em> < 0.01), respectively. Additionally, total lean mass (<em>r</em> = 0.477; <em>P</em> < 0.01), chest lean mass (<em>r</em> = 0.360; <em>P</em> < 0.01), and total lean mass (<em>r</em> = 0.459; <em>P</em> < 0.01) had the strongest correlation coefficients between body composition and BMC. Forward stepwise regression identified age, chest lean mass, and midriff fat mass as predictors of BMC in postmenopausal women; BMI and total lean mass in premenopausal women; and total lean mass in men. For BMD, chest lean mass (postmenopausal), total lean mass (premenopausal), and BMI (men) were significant predictors.</div><div><em>Conclusions:</em> Fat mass does not affect BMD or BMC, while lean mass, strongly predicts bone health. Trunk body composition showed varying relationships with BMD and BMC, making it challenging to pinpoint how lean mass distribution in the chest and midriff specifically impacts bone health.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 3","pages":"Article 101580"},"PeriodicalIF":1.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-09DOI: 10.1016/j.jocd.2025.101579
Marcus Vinícius de Oliveira Cattem, Josely Correa Koury
Background: Bone geometry parameters are essential for evaluating bone health and fracture risk in soccer players, whose physical demands affect their bone characteristics. However, studies on adolescent soccer players linking raw bioelectrical data to bone data are lacking, in addition to potential discrepancies in phase angle (PhA) values obtained using single-frequency (SF-BIA) and multifrequency (MF-BIA) bioelectrical impedance devices.
Aims: In this cross-sectional study, we aimed to compare raw bioelectrical impedance data (resistance (R), reactance (Xc), and PhA values) obtained using SF-BIA and MF-BIA devices and test the relationships among PhA and bioelectrical impedance vector analysis (BIVA) with bone mineral density (BMD), and leg hip-femur geometry (HF-G) parameters in adolescent male soccer players.
Methods: Raw bioelectrical impedance data were assessed using the SF-BIA and MF-BIA devices at a frequency of 50 kHz. The HF-G parameters were obtained by dual-energy X-ray absorptiometry. BIVA was used to compare bone data considering BMD and HF-G median values.
Results: Overall, 59 adolescent male soccer players participated in this study. Raw SF-BIA data had lower R values (-19.3 %, p < 0.001), but higher Xc (+5.3 %, p < 0.001) and PhA values (+20.3 %, p < 0.001) than when using MF-BIA data. PhA values obtained using SF-BIA (r = 0.27, p = 0.04) or MF-BIA (r = 0.43, p < 0.001) were positively correlated with total hip-femur BMD. Considering BIVA, the ellipses differed for the total BMD (p = 0.0018), neck BMD (p = 0.026), and cross-sectional area (p = 0.024).
Conclusion: The PhA and R values obtained using SF-BIA were higher than those obtained using MF-BIA, possibly because of the technological differences between the devices. However, the MF-BIA data suggests that PhA and BIVA can be used as tools for continuous use to warn of possible imbalances in bone tissue.
{"title":"Bioelectrical phase angle and impedance vectors are related to leg hip-femur density and bone geometry parameters in adolescent male soccer players","authors":"Marcus Vinícius de Oliveira Cattem, Josely Correa Koury","doi":"10.1016/j.jocd.2025.101579","DOIUrl":"10.1016/j.jocd.2025.101579","url":null,"abstract":"<div><div><em>Background:</em> Bone geometry parameters are essential for evaluating bone health and fracture risk in soccer players, whose physical demands affect their bone characteristics. However, studies on adolescent soccer players linking raw bioelectrical data to bone data are lacking, in addition to potential discrepancies in phase angle (PhA) values obtained using single-frequency (SF-BIA) and multifrequency (MF-BIA) bioelectrical impedance devices.</div><div><em>Aims:</em> In this cross-sectional study, we aimed to compare raw bioelectrical impedance data (resistance (R), reactance (Xc), and PhA values) obtained using SF-BIA and MF-BIA devices and test the relationships among PhA and bioelectrical impedance vector analysis (BIVA) with bone mineral density (BMD), and leg hip-femur geometry (HF-G) parameters in adolescent male soccer players.</div><div><em>Methods:</em> Raw bioelectrical impedance data were assessed using the SF-BIA and MF-BIA devices at a frequency of 50 kHz. The HF-G parameters were obtained by dual-energy X-ray absorptiometry. BIVA was used to compare bone data considering BMD and HF-G median values.</div><div><em>Results:</em> Overall, 59 adolescent male soccer players participated in this study. Raw SF-BIA data had lower R values (-19.3 %, <em>p</em> < 0.001), but higher Xc (+5.3 %, <em>p</em> < 0.001) and PhA values (+20.3 %, <em>p</em> < 0.001) than when using MF-BIA data. PhA values obtained using SF-BIA (<em>r</em> = 0.27, <em>p</em> = 0.04) or MF-BIA (<em>r</em> = 0.43, <em>p</em> < 0.001) were positively correlated with total hip-femur BMD. Considering BIVA, the ellipses differed for the total BMD (<em>p</em> = 0.0018), neck BMD (<em>p</em> = 0.026), and cross-sectional area (<em>p</em> = 0.024).</div><div><em>Conclusion:</em> The PhA and R values obtained using SF-BIA were higher than those obtained using MF-BIA, possibly because of the technological differences between the devices. However, the MF-BIA data suggests that PhA and BIVA can be used as tools for continuous use to warn of possible imbalances in bone tissue.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 2","pages":"Article 101579"},"PeriodicalIF":1.7,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1016/j.jocd.2025.101577
John T. Schousboe , Neil Binkley , William D. Leslie
Background: Bone mineral density (BMD) measurement is less precise amongst those with body mass index (BMI) > 30 kg/m2. We hypothesized that the association of BMD with incident hip and major osteoporotic fractures (MOF; hip, clinical vertebral, forearm, or humerus) becomes weaker with increasing BMI.
Methodology: Our study population was 75,391 individuals age ≥ 50 years who had a bone density test in the province of Manitoba 1998 to 2018. BMD of the total hip was assessed on GE Lunar densitometers. Incident MOF and hip fractures were ascertained using linked health claims data over a mean (SD) follow-up of 8.6 (5.3) years. The associations of total hip BMD with incident major osteoporotic and hip fractures were estimated with Cox proportional hazards models including an interaction term between BMI category and BMD to test if the association of BMD with incident fractures varies by BMI.
Result: The multivariable adjusted associations of total hip BMD with incident MOF did not vary by BMI (hazard ratio [HR] 1.56, 95 % C.I. 1.30, 1.85 for BMI ≥ 40 kg/m2; HR 1.36, 95 % C.I. 1.17, 1.58 for BMI <18.5 kg/m2; p-value for interaction 0.14). However, the association of total hip BMD with incident hip fracture was stronger for those with BMI ≥ 35 kg/m2 (HR 2.16, 95 % C.I. 1.71, 2.74) compared to those with BMI <18.5 kg/m2 (HR 1.48, 95 % C.I. 1.19, 1.84, p-value 0.001 for interaction).
Conclusion: The associations of total hip BMD with incident major osteoporotic and hip fracture are as strong for those with very high BMI as for those with normal BMI. However, total hip BMD may have a weaker association with incident hip fracture among underweight individuals. Further studies to confirm and explain this finding are warranted.
{"title":"The association of hip bone mineral density (BMD) with incident major osteoporotic and hip fractures varies by body mass index","authors":"John T. Schousboe , Neil Binkley , William D. Leslie","doi":"10.1016/j.jocd.2025.101577","DOIUrl":"10.1016/j.jocd.2025.101577","url":null,"abstract":"<div><div><em>Background:</em> Bone mineral density (BMD) measurement is less precise amongst those with body mass index (BMI) > 30 kg/m<sup>2</sup>. We hypothesized that the association of BMD with incident hip and major osteoporotic fractures (MOF; hip, clinical vertebral, forearm, or humerus) becomes weaker with increasing BMI.</div><div><em>Methodology:</em> Our study population was 75,391 individuals age ≥ 50 years who had a bone density test in the province of Manitoba 1998 to 2018. BMD of the total hip was assessed on GE Lunar densitometers. Incident MOF and hip fractures were ascertained using linked health claims data over a mean (SD) follow-up of 8.6 (5.3) years. The associations of total hip BMD with incident major osteoporotic and hip fractures were estimated with Cox proportional hazards models including an interaction term between BMI category and BMD to test if the association of BMD with incident fractures varies by BMI.</div><div><em>Result:</em> The multivariable adjusted associations of total hip BMD with incident MOF did not vary by BMI (hazard ratio [HR] 1.56, 95 % C.I. 1.30, 1.85 for BMI ≥ 40 kg/m<sup>2</sup>; HR 1.36, 95 % C.I. 1.17, 1.58 for BMI <18.5 kg/m<sup>2</sup>; p-value for interaction 0.14). However, the association of total hip BMD with incident hip fracture was stronger for those with BMI ≥ 35 kg/m<sup>2</sup> (HR 2.16, 95 % C.I. 1.71, 2.74) compared to those with BMI <18.5 kg/m<sup>2</sup> (HR 1.48, 95 % C.I. 1.19, 1.84, p-value 0.001 for interaction).</div><div><em>Conclusion:</em> The associations of total hip BMD with incident major osteoporotic and hip fracture are as strong for those with very high BMI as for those with normal BMI. However, total hip BMD may have a weaker association with incident hip fracture among underweight individuals. Further studies to confirm and explain this finding are warranted.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 2","pages":"Article 101577"},"PeriodicalIF":1.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号