Journal of Clinical Densitometry最新文献

Corrigendum to 'Osteoporosis prediction from frontal lumbar spine X-rays' [Journal of clinical densitometry, volume 29 (2026), 101666]. “腰椎前位x光预测骨质疏松症”的更正[Journal of clinical density， vol . 29(2026), 101666]。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-31 DOI: 10.1016/j.jocd.2026.101671

Ryusei Inamori, Tomoya Kobayashi, Eichi Takaya, Junya Iwazaki, Carlos Makoto Miyauchi, Saori Ikumi, Yoshikazu Okamoto, Cheng Wei Lin, Sheng Che Hsiao, Qingzong Tseng, Shinya Sonobe

引用次数: 0

Novel DXA body composition approaches: comparison with traditional total body scans. 新的DXA身体成分方法：与传统全身扫描的比较。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-16 DOI: 10.1016/j.jocd.2026.101668

Diane Krueger, Gretta Borchardt, Lucas Andersen, Benjamin Rush, Jevin Lortie, Adam J Kuchnia, Jennifer Sanfilippo, Neil Binkley

Introduction: Traditionally, total body (TB) dual-energy x-ray absorptiometry (DXA) scans to assess body composition include the entire body, however novel abbreviated acquisition methods exist. The purpose of this study was to evaluate comparability of measured and estimated body composition results using three novel acquisition techniques; total body less head (TBLH), neck to knee (NTK) and lower extremity (LE). We hypothesized that body composition mass with these three novel methods would not differ from traditional TB acquisition.

Methods: Each subject had TB, TBLH, NTK and LE scans acquired using a Lunar iDXA. A subset of 30 had repeat NTK and LE scans with repositioning between and a matched historical precision control was compiled from existing data for comparison. TBLH and NTK scans used automated software to limit anatomy scanned; NTK estimated non-scanned lower leg mass. LE scans were acquired from L3 to just beyond the toes. Automated analysis, with manual correction, was used for all but LE scans, which were analyzed manually. Equivalence testing was used to compare regional lean, fat and bone mineral content (BMC) measurements from the novel scanning methods to traditional full TB scans. Precision was determined by the ISCD Precision Calculator and compared to TB historical precision by F-test.

Results: The study sample included 82 subjects, 41F/41 M mean (SD) age 51.0 (18.4) years and BMI 25.5 (3.7) kg/m². Total and regional lean, fat and bone mass were equivalent among all approaches (p < 0.01). There was excellent agreement between sexes and ages with TB and TBLH (p < 0.001). Some clinically irrelevant disagreement was observed in NTK and LE fat and lean measurements while NTK and LE precision was excellent, ranging from 0.45 to 2.31%CV.

Conclusion: These three novel approaches provide regional body composition data consistent with traditional TB measurement and may be considered as equivalent substitutes when appropriate.

传统上，全身（TB）双能x射线吸收仪（DXA）扫描评估身体成分包括整个身体，但是存在新的简化获取方法。本研究的目的是评估使用三种新型采集技术测量和估计的体成分结果的可比性；全身无头部（TBLH）、颈至膝（NTK）和下肢（LE）。我们假设这三种新方法的身体成分质量与传统的结核病获取没有什么不同。方法：每个受试者使用Lunar iDXA进行TB、TBLH、NTK和LE扫描。30个子集进行了重复的NTK和LE扫描，重新定位之间和匹配的历史精度控制从现有数据中编译进行比较。TBLH和NTK扫描使用自动化软件限制解剖扫描；NTK估计未扫描的小腿质量。从L3到脚趾上方进行LE扫描。除了LE扫描外，所有扫描都使用了手动校正的自动分析。LE扫描是手动分析的。等效检验用于比较区域瘦，脂肪和骨矿物质含量（BMC）测量从新的扫描方法和传统的全TB扫描。精度由ISCD精度计算器确定，并通过f检验与TB历史精度进行比较。结果：研究样本包括82名受试者，41 f /41 M，平均（SD）年龄51.0（18.4）岁，BMI 25.5 (3.7) kg/m2。两种方法的总瘦、脂肪和骨量相当（p < 0.01）。结核病和TBLH在性别和年龄之间有很好的一致性（p < 0.001）。在NTK和LE的脂肪和瘦肉测量中观察到一些与临床无关的差异，而NTK和LE的精度非常好，范围从0.45到2.31%CV。结论：这三种新方法提供了与传统结核病测量一致的区域身体成分数据，在适当的时候可以被视为等效替代品。

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引用次数: 0

Sarcopenic obesity negatively affects composite indices of femoral neck strength in premenopausal women 肌少性肥胖对绝经前妇女股骨颈强度综合指标有负向影响

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-12 DOI: 10.1016/j.jocd.2026.101667

Nour Khalil , Rawad El Hage , Emne Hammoud, Elie Maliha, Gisèle El Khoury, Zaher El Hage, Christophe Jacob

引用次数: 0

Bridging diagnostic gaps in osteoporosis and sarcopenia in long-term care: Leveraging a mobile assessment unit for clinical trials and comprehensive musculoskeletal evaluations 弥合长期护理中骨质疏松症和肌肉减少症的诊断差距：利用移动评估单元进行临床试验和全面的肌肉骨骼评估

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 DOI: 10.1016/j.jocd.2025.101664

Nami Safai Haeri , Subashan Perera , Susan L. Greenspan

Background: Osteoporosis and sarcopenia are prevalent in older adults, particularly in long-term care (LTC) settings, where logistical barriers often impede timely musculoskeletal assessments. Traditional mobile DXA services are limited and typically lack integrated evaluations of muscle health and functional performance. The present report shares our experience with an all-in-one mobile assessment unit designed to provide comprehensive musculoskeletal evaluations directly at LTC facilities.

Methods: The mobile unit was deployed across five randomized controlled trials in over 30 LTC facilities from 2007 to 2025. It integrates multiple modalities to evaluate bone and muscle health. We report on feasibility, resource utilization, acceptability, and safety.

Results: A total of 876 individuals were enrolled in the trials and underwent 3,623 assessments in the mobile unit, including screenings of non-enrolled individuals and repeated visits during 2–3 years of follow-up among enrolled participants. The mobile unit effectively conducted comprehensive assessments within 45 to 60 min per participant. No device-related adverse events occurred.

Conclusion: This mobile assessment model offers a scalable solution to enhance musculoskeletal care access for older adults in LTC settings. Future directions include expanding its use to underserved populations and integrating telehealth capabilities to further improve care delivery.

背景：骨质疏松症和肌肉减少症在老年人中很普遍，特别是在长期护理（LTC）环境中，后勤障碍经常阻碍及时的肌肉骨骼评估。传统的移动DXA服务是有限的，通常缺乏对肌肉健康和功能表现的综合评估。本报告分享了我们的经验，一个一体化的移动评估单元，旨在提供全面的肌肉骨骼评估直接在LTC设施。方法：从2007年到2025年，在30多个LTC设施的5个随机对照试验中部署了移动单元。它整合了多种方式来评估骨骼和肌肉健康。我们报告了可行性、资源利用率、可接受性和安全性。结果：共有876人参加了试验，并在移动单元中进行了3,623次评估，包括对未参加试验的人进行筛查，并在参加试验的参与者中进行了2-3年的随访。流动小组在每位参与者45至60分钟内有效地进行了全面评估。未发生与器械相关的不良事件。结论：这种移动评估模型提供了一种可扩展的解决方案，以增强老年人在LTC环境中的肌肉骨骼护理。未来的方向包括将其扩大到服务不足的人群，并整合远程保健能力，以进一步改善保健服务。

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引用次数: 0

Exploring body composition ratios and their relation to cardiometabolic disease risk factors in adults with varying body mass index categories 探讨不同体重指数类别成人的身体组成比及其与心脏代谢疾病危险因素的关系

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 DOI: 10.1016/j.jocd.2025.101661

Hannah E. Westerberg , Madeline A. Czeck , Donald R. Dengel , Lisa S. Chow

Introduction: Muscle and bone are impacted by adiposity and metabolic dysfunction. To investigate their relationship, we assessed total and regional muscle-to-bone (MBR) and soft tissue-to-bone (SBR) ratios and their association with cardiometabolic risk factors in adults across body mass indexes (BMIs).

Methodology: This study included 152 males (n=58; age 28.8±6.4 yrs) and females (n=94; age 28.1±6.8 yrs) with different BMIs. Dual X-ray absorptiometry provided lean mass, fat mass, and bone mineral content. ANCOVA with Bonferroni correction assessed ratio differences between BMIs while controlling for age. Linear regression assessed associations between the ratios with insulin, glucose, homeostatic model assessment of insulin resistance (HOMA-IR), triglycerides, total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein, TC:HDL ratio, and blood pressure while controlling for BMI and self-reported exercise status.

Results: Males with obesity (O_M) had higher arm and leg, but not total MBR than males with healthy weight (HW_M). O_M had higher total, arm, and leg SBRs (all p<0.001) than HW_M. Females with obesity (O_F) had higher total, arm, and leg MBRs and SBRs than healthy weight (HW_F) (all p<0.01). Controlling for BMI and exercise status in females, total MBR and SBR positively associated with insulin (MBR: adjusted r²=0.24, p=0.02; SBR: adjusted r²=0.25, p=0.01) and HOMA-IR (MBR: adjusted r²=0.28, p=0.04; SBR: adjusted r²=0.30, p=0.01) while SBR associated with TC:HDL ratio (adjusted r²=0.19, p=0.03). No associations were found between the ratios with cardiometabolic outcomes in males.

Conclusions: O_F had higher total and regional MBRs and SBRs than HW_F. O_M had higher regional MBRs and all SBRs than HW_M, but not total MBR. Total MBR and SBR associated positively with insulin and HOMA-IR in females, but not males. In females, SBR also positively associated with TC:HDL ratio. Although higher MBRs and SBRs may relate to higher cardiometabolic risk in females, further research is needed.

肌肉和骨骼受到肥胖和代谢功能障碍的影响。为了研究它们之间的关系，我们评估了总体和区域肌肉与骨（MBR）和软组织与骨（SBR）比率，以及它们与成人身体质量指数（bmi）中心脏代谢危险因素的关系。方法：本研究纳入152例不同bmi的男性58例（年龄28.8±6.4岁）和女性94例（年龄28.1±6.8岁）。双x线吸收仪提供瘦质量、脂肪质量和骨矿物质含量。在控制年龄的情况下，采用Bonferroni校正的ANCOVA评估bmi之间的比率差异。线性回归评估胰岛素、葡萄糖、胰岛素抵抗稳态模型评估（HOMA-IR）、甘油三酯、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白、TC:HDL比率和血压之间的相关性，同时控制BMI和自我报告的运动状态。结果：肥胖男性（OM）的手臂和腿比健康体重男性（HWM）高，但总MBR不高。OM的总sbr、上肢和腿部sbr均高于HWM （p < 0.001）。肥胖女性（OF）的总mbr、手臂和腿部mbr和sbr均高于健康体重（HWF）（p < 0.01）。在控制BMI和运动状态的情况下，总MBR和SBR与胰岛素（调整后的MBR r2=0.24, p=0.02；调整后的SBR r2=0.25, p=0.01）和HOMA-IR（调整后的MBR r2=0.28, p=0.04；调整后的SBR r2=0.30, p=0.01）呈正相关，SBR与TC:HDL比值（调整后的r2=0.19, p=0.03）呈正相关。在男性中，没有发现这些比率与心脏代谢结果之间的关联。结论：OF的总mbr和区域sbr高于HWF。OM的区域MBR和所有sbr均高于HWM，但总MBR高于HWM。在女性中，总MBR和SBR与胰岛素和HOMA-IR呈正相关，而在男性中没有。在女性中，SBR也与TC:HDL比值呈正相关。虽然较高的mbr和sbr可能与女性较高的心脏代谢风险有关，但还需要进一步的研究。

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引用次数: 0

Reference data for peripheral quantitative computed tomography for assessment of bone geometry and strength in Indian children and youth 周边定量计算机断层扫描评估印度儿童和青少年骨骼几何形状和强度的参考数据

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 DOI: 10.1016/j.jocd.2025.101665

Anuradha Khadilkar , Chirantap Oza , Neha Kajale , Vaman Khadilkar , Alex Ireland , Dipali Ladkat , Vivek Patwardhan , Raja Padidela , M. Zulf Mughal

Introduction: Currently, there is a paucity of data for bone geometry and strength parameters for Indian children. This is essential because of differences in stature, body composition, and bone outcomes between Indian children and Western populations on which existing reference data are based. As dual energy X-ray absorptiometry is size dependent, we conducted the present study with the objective of generating age and sex-specific reference centile curves for peripheral quantitative computed tomography (pQCT) for Indian children and adolescents.

Methods: A cross-sectional, observational study was conducted from November 2017 to July 2022 on 961 (501 boys) healthy children aged 8 to 18 years from Pune, India. The XCT-2000 pQCT scanner (Stratec Inc, GmbH, Pforzheim, Germany) was used to measure volumetric trabecular density at 4 % site and volumetric cortical density, polar stress-strain index, cortical thickness, and muscle area at 66 % site of left radius.

Results: We have presented percentile curves for total, trabecular, and cortical density for age, as well as cortical area and cortical thickness for height. A maximum increase in total volumetric density to the preceding age group of 10.7 % was observed in boys at the age of 17 years, whereas a maximum increase of 8 % was observed in girls at the age of 15 years. Average increase in trabecular density was 0.2 % per year. Cortical density was significantly higher in girls (8.7 %) from the age of 13 years as compared to boys. Cortical thickness was significantly higher in girls (13.3 %) as compared to boys at 12 years, while it was higher in boys (9.1 %) at 16 years and 18 years. A steep increase was observed in the cortical area for height and cortical thickness for height in both sexes.

Conclusion: We have established reference curves for pQCT parameters in Indian children and adolescents to aid in the assessment of pediatric bone geometry.

目前，印度儿童的骨几何和强度参数数据缺乏。这是至关重要的，因为印度儿童和西方人口在身高、身体组成和骨骼结果方面存在差异，而这些都是现有参考数据的基础。由于双能x线吸收仪依赖于尺寸，我们进行了本研究，目的是为印度儿童和青少年的外周定量计算机断层扫描（pQCT）生成年龄和性别特异性的参考百分位曲线。方法：2017年11月至2022年7月，对来自印度浦那的961名（501名）8至18岁健康儿童进行了横断面观察性研究。使用XCT-2000 pQCT扫描仪（strategy Inc, GmbH, Pforzheim, Germany）测量左桡骨66%部位的体积小梁密度和体积皮质密度、极应力-应变指数、皮质厚度和肌肉面积。结果：我们给出了年龄的总、小梁和皮质密度的百分位数曲线，以及身高的皮质面积和皮质厚度的百分位数曲线。在17岁的男孩中观察到总体积密度最大增加10.7%，而在15岁的女孩中观察到最大增加8%。小梁密度平均每年增加0.2%。从13岁开始，女孩的皮质密度明显高于男孩（8.7%）。女孩在12岁时的皮质厚度明显高于男孩（13.3%），而男孩在16岁和18岁时的皮质厚度则高于男孩（9.1%）。在两性中，身高的皮质面积和身高的皮质厚度都急剧增加。结论：我们建立了印度儿童和青少年pQCT参数的参考曲线，以帮助评估儿童骨骼几何形状。

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引用次数: 0

Impact of DXA acquisition mode on bone mineral density and longitudinal monitoring: Evidence from the Manitoba BMD registry DXA采集模式对骨密度和纵向监测的影响：来自马尼托巴骨密度登记的证据

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 DOI: 10.1016/j.jocd.2025.101660

Sajjad Aftabi , William D. Leslie

Dual-energy X-ray absorptiometry (DXA) is the gold standard for assessing bone mineral density (BMD), but technical factors such as acquisition mode may affect measurement. On GE Healthcare DXA systems, Thin and Thick modes are often recommended for underweight and obese patients, respectively, while Standard mode is the default. Using the Manitoba Bone Density Program, a population-based registry, we analyzed paired same-day BMD measurements for the lumbar spine (n = 240), total hip (n = 432), and femoral neck (n = 431) obtained in Standard and nonstandard modes. Agreement was assessed by linear regression, Pearson correlation, Bland–Altman plots, and classification of BMD change using site-specific least significant change (LSC) thresholds. Paired Standard and nonstandard modes showed very strong correlations (r ≥ 0.97) with regression slopes approximating unity and intercepts approximating zero. Mean biases were negligible at the lumbar spine (−0.002 g/cm²), total hip (+0.001 g/cm²), and femoral neck (+0.001 g/cm²). Overall Standard versus nonstandard mode change agreement was near-perfect at the spine (Cohen’s κ 0.89) and total hip (κ 0.81), and substantial at the femoral neck (κ 0.75). All observed scan mode differences fell well below established LSC thresholds. These findings demonstrate that Thin and Thick acquisition modes produce BMD results that are effectively interchangeable with Standard mode.

双能x线吸收仪（DXA）是评估骨密度（BMD）的金标准，但采集方式等技术因素可能会影响测量。在GE Healthcare DXA系统上，通常分别推荐体重过轻和肥胖患者使用Thin和Thick模式，而标准模式是默认模式。使用马尼托巴骨密度计划，一个基于人群的登记，我们分析了在标准和非标准模式下获得的腰椎（n = 240）、全髋关节（n = 432）和股骨颈（n = 431）的配对当日骨密度测量值。通过线性回归、Pearson相关性、Bland-Altman图和使用位点特异性最不显著变化（LSC）阈值的BMD变化分类来评估一致性。配对的标准模式和非标准模式显示出很强的相关性（r≥0.97），回归斜率接近于1，截距接近于零。腰椎（- 0.002 g/cm²）、全髋关节（+0.001 g/cm²）和股骨颈（+0.001 g/cm²）的平均偏差可以忽略不计。总体而言，标准与非标准模式改变的一致性在脊柱（Cohen’s κ 0.89）和全髋关节（κ 0.81）处接近完美，在股骨颈（κ 0.75）处相当可观。所有观察到的扫描模式差异都低于既定的LSC阈值。这些发现表明，薄采集模式和厚采集模式产生的BMD结果与标准模式可以有效地互换。

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引用次数: 0

Metabolic and body composition alterations in normal-weight adults with prediabetes: A DEXA-based analysis 正常体重的糖尿病前期成人代谢和身体成分的改变：一项基于dexa的分析

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 DOI: 10.1016/j.jocd.2025.101662

Sami Bahçebaşı , Banu Açmaz , Ahmet Savranlar

Introduction: This study examines clinical, biochemical, and body composition differences between healthy and prediabetic normal-weight individuals (BMI 18.5-24.9 kg/m²), with a focus on central fat distribution.

Methods: Sixty participants (30 prediabetic, 30 healthy) underwent clinical evaluations, including body composition analysis using DEXA.

Results: • Women: Multivariate regression analysis demonstrated that the android-to-gynoid fat ratio remained an independent and significant predictor of prediabetes (p = 0.014).

• Men: GFR and creatinine levels were significantly impaired (p = 0.008, p = 0.019). Central fat distribution, especially trunk fat, correlated with fasting glucose, although this association lost significance after age adjustment.

Discussion: In women, prediabetes is associated with impaired glucose metabolism and central fat accumulation, particularly reflected by an elevated DEXA-derived android/gynoid fat ratio, highlighting a “normal-weight obesity” phenotype even in individuals with normal BMI. In men, central fat distribution, especially the trunk-to-limb fat ratio, is linked to glucose metabolism; however, this relationship diminishes after adjusting for age, suggesting that age-related fat redistribution may modulate metabolic risk. Additionally, early renal dysfunction, as indicated by reduced eGFR, is evident in men with prediabetes, underscoring the importance of comprehensive metabolic and renal assessment. These findings emphasize the clinical relevance of body composition–based screening, particularly using DEXA-derived regional fat ratios, to identify high-risk normal-weight individuals and enable timely preventive interventions.

本研究探讨了健康和糖尿病前期正常体重个体（BMI 18.5-24.9 kg/m²）的临床、生化和身体组成差异，重点研究了中心脂肪分布。方法：60名参与者（30名糖尿病前期，30名健康）接受临床评估，包括DEXA身体成分分析。•女性：多变量回归分析表明，男性与女性的脂肪比仍然是前驱糖尿病的独立且显著的预测因子（p = 0.014）。•男性：GFR和肌酐水平显著降低（p = 0.008, p = 0.019）。中心脂肪分布，特别是躯干脂肪，与空腹血糖相关，尽管这种关联在年龄调整后失去了意义。讨论：在女性中，前驱糖尿病与糖代谢受损和中枢脂肪积累有关，特别是由dexa衍生的android/gynoid脂肪比例升高反映，即使在BMI正常的个体中也突出了“正常体重肥胖”表型。在男性中，中心脂肪分布，特别是躯干与四肢的脂肪比例，与葡萄糖代谢有关；然而，在调整年龄后，这种关系减弱，这表明与年龄相关的脂肪再分配可能会调节代谢风险。此外，早期肾功能障碍，如eGFR降低，在糖尿病前期男性中很明显，强调了综合代谢和肾脏评估的重要性。这些发现强调了基于身体成分的筛查的临床意义，特别是使用dexa衍生的区域脂肪比，以识别高危正常体重个体并及时进行预防性干预。

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引用次数: 0

Analyzing the effect of osteoporosis drug treatments on femoral strength using 3D-DXA finite elements modelling 采用3D-DXA有限元模型分析骨质疏松药物治疗对股骨强度的影响。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 DOI: 10.1016/j.jocd.2025.101663

Carlos Ruiz Wills , Muhammad Qasim , Renaud Winzenrieth , Silvana Di Gregorio , Luis Del Río , Ludovic Humbert , Jérôme Noailly

Osteoporotic hip fracture represents a high social and economic burden in western countries. Pharmacological treatments aim to limit/reverse the loss of bone mineral density (BMD). BMD is monitored through dual energy X-ray absorptiometry (DXA). Biomechanical analysis, through 3D-DXA finite element (FE) femur models, has been shown to potentially improve fracture risk prediction. Yet, the capability of 3D-DXA FE simulations to capture the effects of pharmacological treatments on bone strength remains unexplored. Thus, this study aims to evaluate simulated changes in bone strength in subjects with different osteoporosis treatments using 3D-DXA FE models. A cohort of 155 subjects was used to generate the patient-specific FE models. Osteoporosis treatments included Alendronate (AL, n = 54), Denosumab (DMAB, n = 33), Teriparatide (TPTD, n = 31), and Naïve (NAÏVE, n = 37). Bone was modelled as BMD-dependent elasto-plastic material. Lateral fall was simulated, and bone FE-strength changes from baseline were assessed. Integral FE-strength significantly increased by 3.1% and 4.0% in the AL and DMAB groups, respectively. Trabecular and cortical FE-strength significantly increased by 2.2% and 1.9%, respectively with DMAB. Load-bearing capacity increased in both the cortical and trabecular bone of the femoral neck with DMAB and AL, while it only increased in the trabecular bone with TPTD. 3D-DXA FE analysis might help clinicians to better monitor the effects of pharmacological treatments and potentially improve personalised treatment plans for subjects with osteoporosis.

骨质疏松性髋部骨折在西方国家是一个很高的社会和经济负担。药物治疗的目的是限制/逆转骨密度（BMD）的损失。通过双能x射线吸收仪（DXA）监测骨密度。通过3D-DXA有限元（FE）股骨模型进行生物力学分析，已被证明有可能改善骨折风险预测。然而，3D-DXA FE模拟捕捉药物治疗对骨强度的影响的能力仍未被探索。因此，本研究旨在利用3D-DXA FE模型评估不同骨质疏松治疗受试者骨强度的模拟变化。155名受试者被用于生成患者特异性FE模型。治疗骨质疏松的药物包括阿仑膦酸钠（AL, n = 54）、Denosumab （DMAB, n = 33）、特立帕肽（TPTD, n = 31）和Naïve （NAÏVE, n = 37）。骨被建模为依赖于骨密度的弹塑性材料。模拟侧落，评估骨fe强度从基线的变化。AL组和DMAB组整体fe强度分别显著提高3.1%和4.0%。添加DMAB后，骨小梁和皮质fe强度分别显著提高2.2%和1.9%。DMAB和AL组股骨颈皮质骨和股骨小梁骨的承重能力均有增加，而TPTD组仅股骨小梁骨的承重能力有增加。3D-DXA FE分析可以帮助临床医生更好地监测药物治疗的效果，并有可能改善骨质疏松症患者的个性化治疗计划。

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引用次数: 0

Osteoporosis prediction from Frontal Lumbar Spine X-rays 腰椎前位x线预测骨质疏松症

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 DOI: 10.1016/j.jocd.2025.101666

Ryusei Inamori , Tomoya Kobayashi , Eichi Takaya , Junya Iwazaki , Carlos Makoto Miyauchi , Saori Ikumi , Yoshikazu Okamoto , Cheng Wei Lin , Sheng Che Hsiao , Qingzong Tseng , Shinya Sonobe

Background: This study aimed to evaluate the performance of DeepXray™ Spina, a software that estimates bone mineral density (BMD) and T-scores from frontal lumbar spine X-ray (FLS-X), in predicting osteoporosis.

Methodology: Patients from a Japanese cohort who underwent both FLS-X and dual-energy X-ray absorptiometry (DXA) using Hologic systems within 30 days at Tohoku University Hospital (May 2014-April 2024) were included. BMD was estimated from FLS-X using DeepXray™ Spina, which was developed using dataset from a Taiwanese Cohort. BMD assessed by DXA (observed BMD) and BMD estimated from FLS-X by DeepXray™ Spina (estimated BMD) were compared using Pearson’s correlation coefficient (PCC) and normalized root mean square error (NRMSE). T-scores were converted to osteoporosis classifications as normal, osteopenia, or osteoporosis following the World Health Organization criteria. Classification performance was evaluated by accuracy, sensitivity, specificity, Cohen’s kappa, and quadratic-weighted Cohen’s kappa.

Results: The correlation between estimated and observed BMD was strong, with a PCC of 0.901 and an NRMSE of 0.070. For osteoporosis classification, the accuracy, sensitivity, specificity, and Cohen’s kappa were as follows: 0.902, 1.000, 0.842, and 0.803 for normal; 0.854, 0.729, 0.924, and 0.673 for osteopenia; 0.951, 0.810, 1.000, and 0.863 for osteoporosis. The quadratic-weighted Cohen’s kappa was 0.884.

Conclusion: This study evaluated the performance of Deep Xray™ Spina in predicting osteoporosis from FLS-X. The software is a practical and reliable tool for predicting osteoporosis, with high performance and robustness.

背景：本研究旨在评估DeepXray™Spina的性能，DeepXray™Spina是一种评估骨矿物质密度（BMD）和腰椎前位x线（FLS-X） t评分的软件，用于预测骨质疏松症。方法：纳入2014年5月至2024年4月在东北大学医院（Tohoku University Hospital）接受FLS-X和双能x线吸收仪（DXA） 30天内使用Hologic系统的日本队列患者。使用DeepXray™Spina从FLS-X中估计BMD，该数据集使用来自台湾队列的数据集开发。采用Pearson相关系数（PCC）和标准化均方根误差（NRMSE）对DXA评估的骨密度（观察骨密度）和DeepXray™Spina从FLS-X估计的骨密度（估计骨密度）进行比较。按照世界卫生组织的标准，将t评分转换为骨质疏松症分类为正常、骨质减少或骨质疏松症。通过准确性、敏感性、特异性、Cohen’s kappa和二次加权Cohen’s kappa来评估分类效果。结果：BMD估计值与实测值相关性强，PCC为0.901，NRMSE为0.070。骨质疏松症分类的准确性、敏感性、特异性和Cohen’s kappa值分别为：正常为0.902、1.000、0.842、0.803；骨质减少为0.854、0.729、0.924、0.673；骨质疏松率分别为0.951、0.810、1.000、0.863。二次加权Cohen’s kappa为0.884。结论：本研究评估了Deep Xray™Spina在预测FLS-X骨质疏松症中的作用。该软件是预测骨质疏松症的实用可靠的工具，具有高性能和鲁棒性。

{"title":"Osteoporosis prediction from Frontal Lumbar Spine X-rays","authors":"Ryusei Inamori , Tomoya Kobayashi , Eichi Takaya , Junya Iwazaki , Carlos Makoto Miyauchi , Saori Ikumi , Yoshikazu Okamoto , Cheng Wei Lin , Sheng Che Hsiao , Qingzong Tseng , Shinya Sonobe","doi":"10.1016/j.jocd.2025.101666","DOIUrl":"10.1016/j.jocd.2025.101666","url":null,"abstract":"<div><div><em>Background:</em> This study aimed to evaluate the performance of DeepXray™ Spina, a software that estimates bone mineral density (BMD) and T-scores from frontal lumbar spine X-ray (FLS-X), in predicting osteoporosis.</div><div><em>Methodology:</em> Patients from a Japanese cohort who underwent both FLS-X and dual-energy X-ray absorptiometry (DXA) using Hologic systems within 30 days at Tohoku University Hospital (May 2014-April 2024) were included. BMD was estimated from FLS-X using DeepXray™ Spina, which was developed using dataset from a Taiwanese Cohort. BMD assessed by DXA (observed BMD) and BMD estimated from FLS-X by DeepXray™ Spina (estimated BMD) were compared using Pearson’s correlation coefficient (PCC) and normalized root mean square error (NRMSE). T-scores were converted to osteoporosis classifications as normal, osteopenia, or osteoporosis following the World Health Organization criteria. Classification performance was evaluated by accuracy, sensitivity, specificity, Cohen’s kappa, and quadratic-weighted Cohen’s kappa.</div><div><em>Results:</em> The correlation between estimated and observed BMD was strong, with a PCC of 0.901 and an NRMSE of 0.070. For osteoporosis classification, the accuracy, sensitivity, specificity, and Cohen’s kappa were as follows: 0.902, 1.000, 0.842, and 0.803 for normal; 0.854, 0.729, 0.924, and 0.673 for osteopenia; 0.951, 0.810, 1.000, and 0.863 for osteoporosis. The quadratic-weighted Cohen’s kappa was 0.884.</div><div><em>Conclusion:</em> This study evaluated the performance of Deep Xray™ Spina in predicting osteoporosis from FLS-X. The software is a practical and reliable tool for predicting osteoporosis, with high performance and robustness.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101666"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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