Oxidative stress-mediated protein sulfenylation in human diseases: Past, present, and future

IF 10.7 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Biology Pub Date : 2024-08-30 DOI:10.1016/j.redox.2024.103332
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Abstract

Reactive Oxygen Species (ROS) refer to a variety of derivatives of molecular oxygen that play crucial roles in regulating a wide range of physiological and pathological processes. Excessive ROS levels can cause oxidative stress, leading to cellular damage and even cell demise. However, moderately elevated levels of ROS can mediate the oxidative post-translational modifications (oxPTMs) of redox-sensitive proteins, thereby affecting protein functions and regulating various cellular signaling pathways. Among the oxPTMs, ROS-induced reversible protein sulfenylation represents the initial form of cysteine oxidation for sensing redox signaling. In this review, we will summarize the discovery, chemical formation, and detection approaches of protein sulfenylation. In addition, we will highlight recent findings for the roles of protein sulfenylation in various diseases, including thrombotic disorders, diabetes, cardiovascular diseases, neurodegenerative diseases, and cancer.

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人类疾病中氧化应激介导的蛋白质亚磺酰化:过去、现在和未来
活性氧(ROS)是指分子氧的各种衍生物,它们在调节各种生理和病理过程中发挥着至关重要的作用。过高的 ROS 水平会造成氧化应激,导致细胞损伤甚至死亡。然而,适度升高的 ROS 水平可以介导氧化还原敏感蛋白的氧化翻译后修饰(oxPTMs),从而影响蛋白质功能并调节各种细胞信号通路。在氧化后修饰(oxPTMs)中,ROS 诱导的可逆蛋白质亚磺酰化代表了半胱氨酸氧化感知氧化还原信号的最初形式。在本综述中,我们将总结蛋白质亚磺酰化的发现、化学形成和检测方法。此外,我们还将重点介绍蛋白质亚磺酰化在各种疾病(包括血栓性疾病、糖尿病、心血管疾病、神经退行性疾病和癌症)中的作用的最新发现。
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来源期刊
Redox Biology
Redox Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
19.90
自引率
3.50%
发文量
318
审稿时长
25 days
期刊介绍: Redox Biology is the official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe. It is also affiliated with the International Society for Free Radical Research (SFRRI). This journal serves as a platform for publishing pioneering research, innovative methods, and comprehensive review articles in the field of redox biology, encompassing both health and disease. Redox Biology welcomes various forms of contributions, including research articles (short or full communications), methods, mini-reviews, and commentaries. Through its diverse range of published content, Redox Biology aims to foster advancements and insights in the understanding of redox biology and its implications.
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