Statistical uncertainty principle in Markov kinetics

Abstract

A reciprocality between the statistical variance of observables of a thermodynamic state and that of their conjugate variables, as entropic forces, originates from the thermodynamic conjugacy with respect to an entropy function. This thermodynamic uncertainty principle in equilibrium can be derived from the Maximum Entropy principle and is independent upon underlying mechanistic details. We present, based on the Maximum Caliber principle as the dynamic generalization of Maximum Entropy, the formalism of the uncertainty principle in kinetics in time homogeneous Markov processes between transitional observables and their conjugate path entropic forces. A stochastic biophysical model for molecular motors is used as an illustrating example. The present work generalizes the phenomenological thermodynamics of uncertainties/fluctuations and is applicable to data ad infinitum.