Innovative nano-shielding for minimizing stray radiation dose in external radiation therapy: A promising approach to enhance patient safety

IF 1.4 3区物理与天体物理 Q3 INSTRUMENTS & INSTRUMENTATION Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms Pub Date : 2024-08-30 DOI:10.1016/j.nimb.2024.165513

Saeed Rajabpour , Ghada Almisned , H.O. Tekin , Asghar Mesbahi

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Abstract

This study investigates the effectiveness of novel nanocomposite shielding materials in reducing out-of-field radiation doses during radiation therapy, employing Geant4 Monte Carlo (MC) simulations alongside an anthropomorphic female phantom. The research focuses on two radiation modalities: 6 MV beams with and without flattening filters. Utilizing the Geant4 MC code, detailed simulations of a Varian Clinac 2100C/D linear accelerator and an ICRP-145 mesh-type human phantom were conducted to estimate the doses to out-of-field organs from unintended secondary radiation. This involved simulating a comprehensive linac model, including all relevant beam-line components, and assessing the shielding effects of three different nanocomposites doped with metal nanoparticles at various thicknesses. The nanocomposites, comprising Polytetrafluoroethylene (PTFE), with PtO₂, IrO₂, and Bi₂O₃ nanoparticles, were evaluated for their potential to reduce patient organ doses from stray photon doses. The results showed that these materials could significantly lower radiation exposure to non-target tissues.

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在体外放射治疗中减少杂散辐射剂量的创新纳米屏蔽：提高患者安全的有效方法

本研究采用 Geant4 蒙地卡罗 (MC) 模拟和拟人女性模型，研究新型纳米复合屏蔽材料在减少放射治疗过程中场外辐射剂量方面的有效性。研究重点是两种辐射模式：使用和不使用扁平化滤波器的 6 MV 射束。利用 Geant4 MC 代码，对瓦里安 Clinac 2100C/D 直线加速器和 ICRP-145 网格型人体模型进行了详细模拟，以估算意外二次辐射对场外器官造成的剂量。这包括模拟包括所有相关束线组件在内的综合直线加速器模型，以及评估三种不同厚度的掺杂金属纳米颗粒的纳米复合材料的屏蔽效果。这些纳米复合材料由聚四氟乙烯（PTFE）与二氧化铂（PtO2）、二氧化铱（IrO2）和氧化铋（Bi2O3）纳米粒子组成，评估了它们减少病人器官受杂散光子剂量影响的潜力。结果表明，这些材料可以大大降低非目标组织受到的辐射照射。

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来源期刊

Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms 物理-核科学技术

CiteScore

2.80

自引率

7.70%

发文量

231

审稿时长

1.9 months

期刊介绍： Section B of Nuclear Instruments and Methods in Physics Research covers all aspects of the interaction of energetic beams with atoms, molecules and aggregate forms of matter. This includes ion beam analysis and ion beam modification of materials as well as basic data of importance for these studies. Topics of general interest include: atomic collisions in solids, particle channelling, all aspects of collision cascades, the modification of materials by energetic beams, ion implantation, irradiation - induced changes in materials, the physics and chemistry of beam interactions and the analysis of materials by all forms of energetic radiation. Modification by ion, laser and electron beams for the study of electronic materials, metals, ceramics, insulators, polymers and other important and new materials systems are included. Related studies, such as the application of ion beam analysis to biological, archaeological and geological samples as well as applications to solve problems in planetary science are also welcome. Energetic beams of interest include atomic and molecular ions, neutrons, positrons and muons, plasmas directed at surfaces, electron and photon beams, including laser treated surfaces and studies of solids by photon radiation from rotating anodes, synchrotrons, etc. In addition, the interaction between various forms of radiation and radiation-induced deposition processes are relevant.