miRNA-based electrochemical biosensors for ovarian cancer

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY Clinica Chimica Acta Pub Date : 2024-08-28 DOI:10.1016/j.cca.2024.119946

Saber Rouhi , Hassan Ghasemi , Mehdi Alizadeh , Ahmad Movahedpour , Farzaneh Vahedi , Mehdi Fattahi , Saleh Aiiashi , Seyyed Hossein Khatami

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Abstract

Ovarian cancer, a prevalent and deadly cancer among women, presents a significant challenge for early detection due to its heterogeneous nature. MicroRNAs, short non-coding regulatory RNA fragments, play a role in various cellular processes. Aberrant expression of these microRNAs has been observed in the carcinogenesis-related processes of many cancer types. Numerous studies highlight the critical role of microRNAs in the initiation and progression of ovarian cancer. Given their clinical importance and predictive value, there has been considerable interest in developing simple, prompt, and sensitive miRNA biosensor strategies. Among these, electrochemical sensors have demonstrated advantageous characteristics such as simplicity, sensitivity, low cost, and scalability. These microRNA-based electrochemical biosensors are valuable tools for early detection and point-of-care applications. This article discusses the potential role of microRNAs in ovarian cancer and recent advances in the development of electrochemical biosensors for miRNA detection in ovarian cancer samples.

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基于 miRNA 的卵巢癌电化学生物传感器

卵巢癌是女性中普遍存在的致命癌症，由于其异质性，为早期检测带来了巨大挑战。MicroRNA 是一种短小的非编码调控 RNA 片段，在各种细胞过程中发挥作用。在许多癌症类型的致癌相关过程中都观察到了这些 microRNA 的异常表达。大量研究强调了 microRNA 在卵巢癌的发生和发展过程中的关键作用。鉴于其临床重要性和预测价值，人们对开发简单、快速和灵敏的 miRNA 生物传感器策略产生了浓厚的兴趣。其中，电化学传感器已显示出简单、灵敏、低成本和可扩展性等优势特点。这些基于 microRNA 的电化学生物传感器是早期检测和护理点应用的重要工具。本文讨论了微 RNA 在卵巢癌中的潜在作用，以及用于检测卵巢癌样本中 miRNA 的电化学生物传感器的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.