Whole genome sequencing reveals that five genes are related to BW trait in sheep

IF 4 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animal Pub Date : 2024-09-01 DOI:10.1016/j.animal.2024.101282

X. Xiang , C. Peng , D. Cao , Z. Chen , H. Jin , S. Nie , Y. Xie , X. Chen , Z. Wang

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Abstract

BW is an important economic trait in sheep that influences growth and development. Currently, most studies have used a single approach to screen genes associated with BW traits in sheep. To address this limitation, we conducted a genome-wide association study (GWAS) covering four different BW periods: birth, weaning, 6 months, and 12 months. Five new candidate genes: MAP3K1, ANKRD55, ABCB1, MEF2C and TRNAW-CCA-87 were screened using a combination of GWAS and quantitative trait loci analysis in sheep. Additionally, five genes were subjected to Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. These genes were primarily enriched in pathways related to growth hormone and energy metabolism. The results demonstrated that the above genes potentially influenced the growth and development of sheep. The five new candidate genes are closely related to the BW trait in sheep, which will be valuable for understanding the genetic mechanisms underlying BW traits and for guiding sheep breeding.

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全基因组测序发现五个基因与绵羊的体重特征有关

体重是影响绵羊生长发育的重要经济性状。目前，大多数研究都采用单一方法筛选与绵羊体重性状相关的基因。为了解决这一局限性，我们进行了一项全基因组关联研究（GWAS），涵盖了四个不同的体重期：出生、断奶、6 个月和 12 个月。五个新的候选基因我们结合绵羊的 GWAS 和数量性状位点分析，筛选出了五个新的候选基因：MAP3K1、ANKRD55、ABCB1、MEF2C 和 TRNAW-CCA-87。此外，还对五个基因进行了基因本体和京都基因和基因组百科全书通路富集分析。这些基因主要富集在与生长激素和能量代谢相关的通路中。结果表明，上述基因对绵羊的生长发育有潜在影响。这五个新的候选基因与绵羊的体重性状密切相关，对了解绵羊体重性状的遗传机制和指导绵羊育种具有重要价值。

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来源期刊

Animal 农林科学-奶制品与动物科学

CiteScore

7.50

自引率

2.80%

发文量

246

审稿时长

3 months

期刊介绍： Editorial board animal attracts the best research in animal biology and animal systems from across the spectrum of the agricultural, biomedical, and environmental sciences. It is the central element in an exciting collaboration between the British Society of Animal Science (BSAS), Institut National de la Recherche Agronomique (INRA) and the European Federation of Animal Science (EAAP) and represents a merging of three scientific journals: Animal Science; Animal Research; Reproduction, Nutrition, Development. animal publishes original cutting-edge research, ''hot'' topics and horizon-scanning reviews on animal-related aspects of the life sciences at the molecular, cellular, organ, whole animal and production system levels. The main subject areas include: breeding and genetics; nutrition; physiology and functional biology of systems; behaviour, health and welfare; farming systems, environmental impact and climate change; product quality, human health and well-being. Animal models and papers dealing with the integration of research between these topics and their impact on the environment and people are particularly welcome.