Characterizing human respiratory syncytial virus among children admitted with acute respiratory tract infections from 2019 to 2022

IF 6.8 3区医学 Q1 VIROLOGY Journal of Medical Virology Pub Date : 2024-08-29 DOI:10.1002/jmv.29896

Ferdinamarie Sharmila Philomenadin, Shameema Mohammed, Sangitha Jayagandan, Narayan Ramamurthy, Vimal Raj Ratchagadasse, Venkatesh Chandrasekaran, Rahul Dhodapkar

{"title":"Characterizing human respiratory syncytial virus among children admitted with acute respiratory tract infections from 2019 to 2022","authors":"Ferdinamarie Sharmila Philomenadin, Shameema Mohammed, Sangitha Jayagandan, Narayan Ramamurthy, Vimal Raj Ratchagadasse, Venkatesh Chandrasekaran, Rahul Dhodapkar","doi":"10.1002/jmv.29896","DOIUrl":null,"url":null,"abstract":"Respiratory syncytial virus is a major causative agent of lower respiratory tract infection in children, especially infants with substantial morbidity and mortality implications. The virus undergoes continuous evolution documented by accumulation of mutations in the glycoprotein gene necessitating vigilant surveillance to provide essential data to epidemiologists and researchers involved in development of vaccines. This study was aimed to perform molecular characterization of respiratory syncytial virus (RSV) among children ≤ 5 years admitted in hospital. In the current study we observed RSV-A (2019 (n = 95) and 2021 (n = 61) seasons) and RSV-B (2022 season (n = 68)). Phylogenetic analysis revealed all RSV-A strains (n = 47) to be GA.2.3.5 and RSV-B (n = 22) were classified as GB.5.0.5a. Selection pressure analysis identified one positive (P274L/V) and one negative site (P230T) in RSV–A, while in RSV-B there was only one negatively selected site (S295). This study spanning over three seasons contributes to RSV evolutionary dynamics in India emphasizing the importance of on-going surveillance to inform effective public health strategies and vaccine development efforts.","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":null,"pages":null},"PeriodicalIF":6.8000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Virology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jmv.29896","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VIROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Respiratory syncytial virus is a major causative agent of lower respiratory tract infection in children, especially infants with substantial morbidity and mortality implications. The virus undergoes continuous evolution documented by accumulation of mutations in the glycoprotein gene necessitating vigilant surveillance to provide essential data to epidemiologists and researchers involved in development of vaccines. This study was aimed to perform molecular characterization of respiratory syncytial virus (RSV) among children ≤ 5 years admitted in hospital. In the current study we observed RSV-A (2019 (n = 95) and 2021 (n = 61) seasons) and RSV-B (2022 season (n = 68)). Phylogenetic analysis revealed all RSV-A strains (n = 47) to be GA.2.3.5 and RSV-B (n = 22) were classified as GB.5.0.5a. Selection pressure analysis identified one positive (P274L/V) and one negative site (P230T) in RSV–A, while in RSV-B there was only one negatively selected site (S295). This study spanning over three seasons contributes to RSV evolutionary dynamics in India emphasizing the importance of on-going surveillance to inform effective public health strategies and vaccine development efforts.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

2019 年至 2022 年急性呼吸道感染住院儿童中人类呼吸道合胞病毒的特征

呼吸道合胞病毒是儿童，尤其是婴儿下呼吸道感染的主要致病菌，具有严重的发病率和死亡率。该病毒通过糖蛋白基因突变的积累不断进化，因此有必要对其进行警惕性监测，以便为流行病学家和参与疫苗开发的研究人员提供重要数据。本研究旨在对住院的 5 岁以下儿童中的呼吸道合胞病毒（RSV）进行分子鉴定。在本次研究中，我们观察到了 RSV-A（2019 年（n = 95）和 2021 年（n = 61））和 RSV-B（2022 年（n = 68））。系统发育分析表明，所有 RSV-A 株系（n = 47）都属于 GA.2.3.5，RSV-B 株系（n = 22）被归类为 GB.5.0.5a。选择压力分析在 RSV-A 中发现了一个阳性位点（P274L/V）和一个阴性位点（P230T），而在 RSV-B 中只有一个阴性选择位点（S295）。这项跨越三个季节的研究有助于了解印度 RSV 的进化动态，强调了持续监测对有效的公共卫生策略和疫苗开发工作的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.