Revolutionising infection control: building the next generation of phage banks

IF 15.8 1区 医学 Q1 PHARMACOLOGY & PHARMACY Drug Resistance Updates Pub Date : 2024-11-01 DOI:10.1016/j.drup.2024.101143
Braira Wahid, Muhammad Salman Tiwana, Akhtar Ali
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Abstract

The escalating global burden of antimicrobial resistance (AMR) represents a critical public health challenge. This rise in antibiotic resistance is concomitant with heightened antibiotic consumption, with an estimated annual usage of 100,000 to 200,000 tons. A recent systematic review, which analysed data from 204 countries, reported that AMR was responsible for 4.95 million deaths in 2019 (Murray et al., 2022). The growing threat of AMR is imposing a significant financial burden on the global economy, with the CDC reporting an additional annual cost of $20 billion in the U.S. and €9 billion in Europe. The emerging field of bacteriophage therapy offers promising potential as a game-changer in the era of AMR. However, existing literature reveals numerous research gaps and technological challenges, including insufficient information on phage pharmacology, genomics, and a lack of preclinical and clinical data. In addition to conducting further research to address existing knowledge gaps, establishing phage banks in clinical facilities could be a transformative advancement in the fight against AMR.
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彻底改变感染控制:建立下一代噬菌体库
抗菌药耐药性(AMR)在全球范围内不断加剧,对公共卫生构成了严峻挑战。在抗生素耐药性上升的同时,抗生素的消耗量也在增加,估计每年的使用量为 10 万至 20 万吨。最近的一项系统回顾分析了来自 204 个国家的数据,报告称 2019 年有 495 万人死于 AMR(Murray 等人,2022 年)。AMR 日益严重的威胁给全球经济造成了巨大的财政负担,据美国疾病预防控制中心报告,美国每年的额外成本为 200 亿美元,欧洲为 90 亿欧元。在 AMR 时代,噬菌体疗法这一新兴领域有望改变游戏规则。然而,现有文献揭示了许多研究空白和技术挑战,包括噬菌体药理学、基因组学方面的信息不足,以及缺乏临床前和临床数据。除了开展进一步的研究以解决现有的知识差距外,在临床设施中建立噬菌体库可能会成为抗击 AMR 的变革性进步。
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来源期刊
Drug Resistance Updates
Drug Resistance Updates 医学-药学
CiteScore
26.20
自引率
11.90%
发文量
32
审稿时长
29 days
期刊介绍: Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research
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