Damage to the behavior and physiological functions of Apis mellifera (Hymenoptera: Apidae) by monocrotaline via the modulation of tryptophan metabolism and the corazonin receptor.

IF 8 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Science of the Total Environment Pub Date : 2024-11-20 Epub Date: 2024-08-30 DOI:10.1016/j.scitotenv.2024.175931

Qi Hua, Xuepeng Chi, Wei Zhang, Hongyu Song, Ying Wang, Zhenguo Liu, Hongfang Wang, Baohua Xu

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Abstract

Monocrotaline (MCT) is a toxic pyrrolizidine alkaloid found in plants of the Crotalaria genus. As primary pollinators of Crotalaria plants, honeybees come into contact with this harmful substance. However, limited research has been conducted on the effects of MCT on Apis mellifera, particularly the risks of long-term exposure to sublethal concentrations. Through evaluating the proboscis extension reflex (PER) ability, analyzing the honeybee brain transcriptome, and analyzing the honeybee hemolymph metabolome, we discovered that sublethal concentrations of MCT impair the olfactory and memory capabilities of honeybees by affecting tryptophan (Trp) metabolism. Furthermore, MCT upregulates the expression of the corazonin receptor (CrzR) gene in the honeybee brain, which elevates reactive oxygen species (ROS) levels in the brain while reducing glucose levels in the hemolymph, consequently shortening the honeybees' lifespan. Our findings regarding the multifaceted impact of MCT on honeybees lay the foundation for exploring its toxicological pathways and management in honeybee populations.

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单克洛林通过调节色氨酸代谢和花冠素受体对蜜蜂行为和生理功能的损害

Monocrotaline (MCT) 是一种有毒的吡咯烷生物碱，存在于 Crotalaria 属植物中。作为 Crotalaria 植物的主要传粉者，蜜蜂会接触到这种有害物质。然而，有关 MCT 对蜜蜂的影响，特别是长期接触亚致死浓度的风险的研究还很有限。通过评估蜜蜂的探喙伸展反射（PER）能力、分析蜜蜂大脑转录组和蜜蜂血淋巴代谢组，我们发现亚致死浓度的MCT会影响色氨酸（Trp）的代谢，从而损害蜜蜂的嗅觉和记忆能力。此外，MCT 会上调蜜蜂大脑中 Corazonin 受体（CrzR）基因的表达，从而提高大脑中活性氧（ROS）的水平，同时降低血淋巴中的葡萄糖水平，从而缩短蜜蜂的寿命。我们关于 MCT 对蜜蜂多方面影响的研究结果，为探索其毒性途径和蜜蜂种群管理奠定了基础。

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公司名称

产品信息

阿拉丁

corazonin

来源期刊

Science of the Total Environment 环境科学-环境科学

CiteScore

17.60

自引率

10.20%

发文量

8726

审稿时长

2.4 months

期刊介绍： The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.