A compact and low-frequency drive ultrasound transducer for facilitating cavitation-assisted drug permeation via skin.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Biomedical Physics & Engineering Express Pub Date : 2024-09-16 DOI:10.1088/2057-1976/ad7596
Shinya Yamamoto, Naohiro Sugita, Keita Tomioka, Tadahiko Shinshi
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Abstract

Low-frequency sonophoresis has emerged as a promising minimally invasive transdermal drug delivery method. However, effectively inducing cavitation on the skin surface with a compact, low-frequency ultrasound transducer poses a significant challenge. This paper presents a modified design of a low-frequency ultrasound transducer capable of generating ultrasound cavitation on the skin surfaces. The transducer comprises a piezoelectric ceramic disk and a bowl-shaped acoustic resonator. A conical slit structure was incorporated into the modified transducer design to amplify vibration displacement and enhance the maximum sound pressure. The FEM-based simulation results confirmed that the maximum sound pressure at the resonance frequency of 78 kHz was increased by 1.9 times that of the previous design. Ultrasound cavitation could be experimentally observed on the gel surface. Moreover, 3 min of ultrasound treatment significantly improved the caffeine permeability across an artificial membrane. These results demonstrated that this transducer holds promise for enhancing drug permeation by generating ultrasound cavitation on the skin surface.

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用于促进空化辅助药物经皮肤渗透的紧凑型低频驱动超声换能器。
低频声波电泳已成为一种前景广阔的微创透皮给药方法。然而,使用紧凑型低频超声换能器在皮肤表面有效诱导空化是一项重大挑战。本文介绍了一种能够在皮肤表面产生超声空化的低频超声换能器的改进设计。该换能器由一个压电陶瓷盘和一个碗形声学谐振器组成。在改进的换能器设计中加入了锥形缝隙结构,以放大振动位移并提高最大声压。基于有限元的模拟结果证实,共振频率为 78 kHz 时的最大声压比以前的设计提高了 1.9 倍。通过实验可以在凝胶表面观察到超声空化现象。此外,3 分钟的超声处理显著改善了咖啡因在人工膜上的渗透性。这些结果表明,这种传感器有望通过在皮肤表面产生超声空化来提高药物渗透性。
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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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