Prostate Cancer Disparities in Clinical Characteristics and Survival among Black and Latino Patients Considering Nativity: Findings from the California Cancer Registry.

IF 3.7 3区 医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-11-01 DOI:10.1158/1055-9965.EPI-24-0678
Alexis R Freedland, Joel Sanchez Mendez, Lihua Liu, Ann S Hamilton, Juanjuan Zhang, Amie E Hwang, Leslie Ballas, Andre Luis Abreu, Dennis Deapen, Mariana C Stern
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Abstract

Background: We investigated clinical characteristics and prostate cancer survival patterns among Latino patients considering nativity compared with non-Latino Black (NLB) and non-Latino White (NLW) patients.

Methods: We used data from the California Cancer Registry (1995-2021), which included 347,540 NLW, 50,032 NLB, and 75,238 Latino patients with prostate cancer. Frequencies of sociodemographic and clinical variables were assessed using χ2 tests. Multivariable regression models were fitted to evaluate determinants of treatment reception, Gleason upgrade, and survival differences. Exploratory analyses were conducted grouping Latino cases into US born and non-US born by country of origin.

Results: Compared with NLW, NLB cases had the greatest proportion of younger patients, whereas non-US-born Latino patients had the greatest proportion of low socioeconomic status and uninsured patients. Non-US-born Latinos showed a greater proportion of diagnoses completed with <6 core biopsies, Gleason >8, stage IV tumors, and metastasis. Multivariable analyses showed that compared with NLW, Latino patients were as likely to receive treatment, whereas NLB cases were less likely (OR = 0.81; 95% confidence interval, 0.67-0.98; P = 0.029). Compared with NLW, non-US-born Latino cases were less likely to die of prostate cancer (HR = 0.78; 95% confidence interval, 0.64-0.94; P = 0.011), with no difference reported for NLB cases.

Conclusions: Considering sociodemographic and clinical characteristics, non-US-born Latino patients with prostate cancer had better survival than NLW. This highlights the need to identify key determinants of these survival differences and the importance of sociodemographic and clinical determinants in survival disparities.

Impact: Our study emphasizes the importance of considering nativity among Latino patients to understand prostate cancer disparities and outcomes in this population.

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前列腺癌在黑人和拉丁裔患者中的临床和存活模式差异(考虑出生地):来自加利福尼亚癌症登记处的研究结果。
背景:我们对拉丁裔患者的临床特征和前列腺癌(PCa)生存模式进行了调查,并将其与非拉丁裔黑人(NLB)和非拉丁裔白人(NLW)患者进行了比较:我们使用了加州癌症登记处(1995-2021 年)的数据,其中包括 347,540 名非拉丁裔黑人、50,032 名非拉丁裔白人和 75,238 名拉丁裔 PCa 患者。社会人口学和临床变量的频率通过Chi-square检验进行评估。多变量回归模型用于评估治疗接受度、Gleason 升级和生存率差异的决定因素。根据原籍国将拉丁裔病例分为美国出生和非美国出生两组,并进行了探索性分析:与北大西洋公约组织相比,北大西洋公约组织病例中年轻患者的比例最高,而非美国出生的拉丁裔患者中社会经济地位低和无保险的患者比例最高。非美国出生的拉美裔患者中,诊断为8期、IV期肿瘤和转移瘤的比例更高。多变量分析表明,与北大西洋公约组织相比,拉丁裔患者接受治疗的可能性相同,而北大西洋公约组织病例接受治疗的可能性较低(OR = 0.81,95% CI:0.67-0.98,p = 0.029)。与北大西洋公约组织相比,非美国出生的拉丁裔病例死于 PCa 的可能性较低(HR = 0.78;95% CI = 0.64-0.94,p=0.011),而北大西洋公约组织病例则无差异:考虑到社会人口学和临床特征,非美国出生的拉丁裔 PCa 患者的生存率高于非拉丁裔。这凸显了确定这些生存率差异关键决定因素的必要性,以及社会人口学和临床决定因素在生存率差异中的重要性:影响:我们的研究强调了考虑拉丁裔患者的原籍对了解该人群的 PCa 差异和预后的重要性。
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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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