The role of stathmin expression in the differential diagnosis, prognosis, and potential treatment of ovarian sex cord-stromal tumors.

IF 2.4 3区医学 Q2 PATHOLOGY Diagnostic Pathology Pub Date : 2024-08-30 DOI:10.1186/s13000-024-01541-x

Adam Šafanda, Michaela Kendall Bártů, Romana Michálková, Marián Švajdler, Tetiana Shatokhina, Jan Laco, Radoslav Matěj, Gábor Méhes, Jana Drozenová, Jitka Hausnerová, Zuzana Špůrková, Jozef Škarda, Mária Hácová, Monika Náležinská, Pavel Dundr, Kristýna Němejcová

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Abstract

Background: Stathmin, a cytosolic microtubule-destabilizing phosphoprotein involved in the regulation of mitosis, is widely expressed in various malignancies and acts as an adverse prognostic factor. Our research analyzed its immunohistochemical expression on a large cohort of ovarian sex cord-stromal tumors, evaluating its potential utility in differential diagnosis, prognosis, and therapeutic application.

Methods: We examined 390 cases of ovarian sex cord-stromal tumors including 281 adult granulosa cell tumors (AGCT), 5 juvenile granulosa cell tumors (JGCT), 33 Sertoli-Leydig cell tumors (SLCT), 50 fibromas/thecomas (F/T), 11 Leydig cell tumors/steroid cell tumors (LCT/SterCT), 5 sex-cord stromal tumors NOS (SCST-NOS), 3 Sertoli cell tumors (SCT), and 2 sclerosing stromal tumors (ScST). Immunohistochemical analysis was performed using TMAs.

Results: Strong expression (> 50%) was observed in all cases of AGCT, JGCT, SLCT, SCST-NOS, SCT and 1 ScST. The other case of ScST exhibited mild expression (5-10%). The negative cases included exclusively F/T and LCT/SterCT, with F/T showing 24% of negative cases and LCT/SterCT comprising 64% of negative cases.

Conclusion: The results of our study indicate that stathmin is neither a prognostic marker nor suitable for the differential diagnosis of challenging cases of ovarian sex cord-stromal tumors. However, its predictive value may be theoretically significant, as a decrease in stathmin expression potentialy influences response to chemotherapy treatment.

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Stathmin表达在卵巢性索间质肿瘤的鉴别诊断、预后和潜在治疗中的作用。

背景：Stathmin是一种参与有丝分裂调控的细胞膜微管稳定磷蛋白，在各种恶性肿瘤中广泛表达，是一种不良预后因素。我们的研究分析了其在大量卵巢性索间质肿瘤中的免疫组化表达，评估了其在鉴别诊断、预后和治疗应用中的潜在作用：我们研究了 390 例卵巢性索-基质肿瘤，包括 281 例成人颗粒细胞瘤（AGCT）、5 例幼年颗粒细胞瘤（JGCT）、33 例绒毛膜-Leydig 细胞瘤（SLCT）、50 例纤维瘤/肉瘤、50个纤维瘤/肉瘤（F/T）、11个Leydig细胞瘤/类固醇细胞瘤（LCT/SterCT）、5个性索间质瘤NOS（SCST-NOS）、3个Sertoli细胞瘤（SCT）和2个硬化性间质瘤（ScST）。使用 TMA 进行了免疫组化分析：在所有 AGCT、JGCT、SLCT、SCST-NOS、SCT 和 1 例 ScST 中均观察到强表达（> 50%）。另一例 ScST 表现为轻度表达（5%-10%）。阴性病例仅包括 F/T 和 LCT/SterCT，其中 F/T 占阴性病例的 24%，LCT/SterCT 占阴性病例的 64%：我们的研究结果表明，stathmin既不是预后标志物，也不适合用于卵巢性索间质肿瘤疑难病例的鉴别诊断。然而，它的预测价值在理论上可能是有意义的，因为stathmin表达的减少可能会影响对化疗治疗的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Pathology 医学-病理学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).