Risk Factors Associated With Drug-Related Side Effects in Children: A Scoping Review.

IF 1.4 Q3 PEDIATRICS Global Pediatric Health Pub Date : 2024-08-27 eCollection Date: 2024-01-01 DOI:10.1177/2333794X241273171

Esmaeel Toni, Haleh Ayatollahi, Reza Abbaszadeh, Alireza Fotuhi Siahpirani

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Abstract

Objective. Children's vulnerability to drug-related side effects has been highlighted in several studies. However, there is no consensus on the risk factors associated with these side effects. This study aimed to investigate risk factors associated with drug-related side effects in children. Methods. This scoping review was conducted across multiple databases. The search strategy was created with a focus on drug-related side effects, as they are more predictable based on the pre-determined risk factors. Data were collected, and reported narratively. Results. The demographic, health, hospital, and drug-related risk factors may cause drug-related side effects in children. Among them, low age, sex, polypharmacy, length of hospitalization, and medications used for comorbidities may increase the risk. Conclusion. While most of the risk factors might be similar in adults and children, their impact might be different in these 2 groups. Therefore, future studies should identify more details about the impact of the risk factors in children.

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与儿童药物副作用相关的风险因素：范围界定综述。

目的。多项研究都强调了儿童容易受到药物副作用的影响。然而，对于与这些副作用相关的风险因素还没有达成共识。本研究旨在调查与儿童药物相关副作用有关的风险因素。研究方法本研究在多个数据库中进行了范围界定。搜索策略主要针对与药物相关的副作用，因为根据预先确定的风险因素，这些副作用更容易预测。收集数据并进行叙述性报告。结果人口、健康、医院和药物相关风险因素可能会导致儿童出现药物相关副作用。其中，低龄、性别、使用多种药物、住院时间和合并症用药可能会增加风险。结论虽然大多数风险因素在成人和儿童中可能相似，但它们对这两个群体的影响可能不同。因此，今后的研究应更详细地确定风险因素对儿童的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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