Estimate of the Deterministic Neutron RBE for Radiation-induced Pseudo-Pelger Huët Cell Formation.

IF 1 4区医学 Q4 ENVIRONMENTAL SCIENCES Health physics Pub Date : 2025-02-01 Epub Date: 2024-09-02 DOI:10.1097/HP.0000000000001881

R E Goans, C J Iddins, R E Goans

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引用次数: 0

Abstract

Abstract: Using archival peripheral blood slides from radiation accident patients, we have recently described the pseudo-Pelger Huët anomaly (PPHA) in neutrophils as a new radiation-induced biomarker, useful for dosimetry not only immediately after a radiation incident but also potentially helpful as a tool in retrospective dosimetry. In conjunction with the Radiation Accident Registry at the Radiation Emergency Assistance Center/Training Site (REAC/TS), the frequency of PPHA cells has been compared from selected patients in the Y-12 criticality accident in Oak Ridge, TN, in 1958 and from the patient in the 1971 60 Co accident at the USAEC Comparative Animal Research Laboratory (CARL), also in Oak Ridge. Patients A, C, and D in the Y-12 accident are described as having an average dose of 2.53 ± 0.14 Gy gamma + 0.90 ± 0.05 Gy neutron, while the patient in the CARL event had 2.6 Gy gamma dose from event reconstruction. Since the average gamma energies are almost identical in these two cohorts, it is possible to estimate the deterministic neutron relative biological effectiveness (RBE d ) for PPHA formation in a criticality event. The neutron RBE d calculated in this way is an average value over the neutron fission energy spectrum and is found to be 3.4 ± 0.6, in good agreement with the currently recommended value of 3 for acute neutron dose to red marrow.

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辐射诱导伪佩尔格-胡埃特细胞形成的确定性中子 RBE 估计。

摘要：最近，我们利用辐射事故患者的外周血档案切片，描述了中性粒细胞中的假性佩尔格-胡埃异常（PPHA），将其作为一种新的辐射诱导生物标志物，不仅可在辐射事故发生后立即用于剂量测定，还可作为一种潜在的工具用于剂量回顾测定。通过与辐射紧急援助中心/培训基地（REAC/TS）的辐射事故登记处合作，对 1958 年田纳西州橡树岭 Y-12 临界事故中的部分患者和 1971 年同样位于橡树岭的美国电算中心比较动物研究实验室（CARL）的 60Co 事故患者的 PPHA 细胞频率进行了比较。据描述，Y-12 事件中的病人 A、C 和 D 的平均伽马剂量为 2.53 ± 0.14 Gy + 0.90 ± 0.05 Gy 中子，而 CARL 事件中的病人从事件重建中得到的伽马剂量为 2.6 Gy。由于这两组患者的平均伽马能量几乎相同，因此可以估算出在临界事件中形成 PPHA 的确定性中子相对生物效应（RBEd）。用这种方法计算出的中子相对生物有效性（RBEd）是中子裂变能谱的平均值，为 3.4 ± 0.6，与目前推荐的红骨髓急性中子剂量值 3 非常吻合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Health physics 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.20

自引率

0.00%

发文量

324

审稿时长

3-8 weeks

期刊介绍： Health Physics, first published in 1958, provides the latest research to a wide variety of radiation safety professionals including health physicists, nuclear chemists, medical physicists, and radiation safety officers with interests in nuclear and radiation science. The Journal allows professionals in these and other disciplines in science and engineering to stay on the cutting edge of scientific and technological advances in the field of radiation safety. The Journal publishes original papers, technical notes, articles on advances in practical applications, editorials, and correspondence. Journal articles report on the latest findings in theoretical, practical, and applied disciplines of epidemiology and radiation effects, radiation biology and radiation science, radiation ecology, and related fields.