Efficacy of hyaluronic acid in temporomandibular disorders evaluated with diagnostic criteria for temporomandibular disorders (DC/TMD)

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of oral rehabilitation Pub Date : 2024-08-29 DOI:10.1111/joor.13840

Pankaj Kukreja, Bhavna Jha Kukreja, Maria Maddalena Marrapodi, Vincenzo Ronsivalle, Marco Cicciù, Giuseppe Minervini

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Abstract

Background

The study aimed to retrospectively assess the efficacy of hyaluronic acid (HA) in managing temporomandibular disorders (TMD) using the diagnostic criteria for temporomandibular disorders (DC/TMD). There has been an ongoing debate regarding the effectiveness of HA as a treatment option for TMD, which necessitated a thorough evaluation.

Methods

The review adhered to PRISMA guidelines conducted across eight different databases, including PubMed, Embase, Web of Science, Cochrane Library, Scopus, ScienceDirect, PsycINFO and CINAHL. The selection criteria included studies that evaluated the efficacy of HA in TMD patients, utilised DC/TMD, and were published in English. Data extraction and quality assessment were performed independently by two reviewers. ROB–2 tool was employed to assess methodological quality of the assessed studies.

Results

A total of 10 studies met the inclusion criteria. They demonstrated that HA was effective in improving various symptoms of TMD, such as pain, mouth opening and joint sounds over control group. But on the other end, platelet-rich plasma (PRP) was found to be better than HA intervention in alleviation of TMD symptoms. However, the degree of improvement varied across the studies. Some studies reported adverse effects, but these were typically minor and transient. Risk of bias assessment was low in all the included studies.

Conclusion

The findings suggest that HA can be an effective treatment for TMD when evaluated with DC/TMD. However, the variation in effectiveness across studies indicates the need for individualised treatment planning and careful monitoring of adverse effects. Further research is needed to refine the treatment protocols and understand the long-term effectiveness and safety of HA in TMD management.

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根据颞下颌关节紊乱症（DC/TMD）诊断标准评估透明质酸对颞下颌关节紊乱症的疗效。

研究背景该研究旨在根据颞下颌关节紊乱症（DC/TMD）的诊断标准，回顾性评估透明质酸（HA）治疗颞下颌关节紊乱症（TMD）的疗效。关于透明质酸治疗 TMD 的有效性一直存在争议，因此有必要对其进行全面评估：综述遵循 PRISMA 准则，在 PubMed、Embase、Web of Science、Cochrane Library、Scopus、ScienceDirect、PsycINFO 和 CINAHL 等八个不同的数据库中进行。选择标准包括评估 HA 对 TMD 患者疗效的研究、使用 DC/TMD 的研究以及以英语发表的研究。数据提取和质量评估由两名审稿人独立完成。采用ROB-2工具评估所评估研究的方法学质量：共有 10 项研究符合纳入标准。这些研究表明，与对照组相比，HA 能有效改善 TMD 的各种症状，如疼痛、张口和关节声。但另一方面，在缓解 TMD 症状方面，富血小板血浆（PRP）的效果优于 HA 干预疗法。不过，不同研究的改善程度各不相同。一些研究报告了不良反应，但这些不良反应通常很轻微，而且是一过性的。所有纳入研究的偏倚风险评估均较低：研究结果表明，在与 DC/TMD 一起评估时，HA 可以有效治疗 TMD。然而，不同研究的疗效存在差异，这表明需要制定个性化的治疗计划并仔细监测不良反应。需要进一步开展研究，以完善治疗方案，了解 HA 在 TMD 治疗中的长期有效性和安全性。

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来源期刊

Journal of oral rehabilitation 医学-牙科与口腔外科

CiteScore

5.60

自引率

10.30%

发文量

116

审稿时长

4-8 weeks

期刊介绍： Journal of Oral Rehabilitation aims to be the most prestigious journal of dental research within all aspects of oral rehabilitation and applied oral physiology. It covers all diagnostic and clinical management aspects necessary to re-establish a subjective and objective harmonious oral function. Oral rehabilitation may become necessary as a result of developmental or acquired disturbances in the orofacial region, orofacial traumas, or a variety of dental and oral diseases (primarily dental caries and periodontal diseases) and orofacial pain conditions. As such, oral rehabilitation in the twenty-first century is a matter of skilful diagnosis and minimal, appropriate intervention, the nature of which is intimately linked to a profound knowledge of oral physiology, oral biology, and dental and oral pathology. The scientific content of the journal therefore strives to reflect the best of evidence-based clinical dentistry. Modern clinical management should be based on solid scientific evidence gathered about diagnostic procedures and the properties and efficacy of the chosen intervention (e.g. material science, biological, toxicological, pharmacological or psychological aspects). The content of the journal also reflects documentation of the possible side-effects of rehabilitation, and includes prognostic perspectives of the treatment modalities chosen.