Oxygen-ozone therapy for myocardial ischemic stroke and cardiovascular disorders.

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Medical Gas Research Pub Date : 2025-03-01 Epub Date: 2024-08-31 DOI:10.4103/mgr.MEDGASRES-D-23-00013
Sergio Pandolfi, Salvatore Chirumbolo, Marianno Franzini, Umberto Tirelli, Luigi Valdenassi
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Abstract

Cardiovascular diseases (CVDs) represent a major concern for human health worldwide. Emergencies in this field include wide repertories of studies dealing primarily with CVD prevention. In addition to dietary habits and lifestyles, medical knowledge is fully needed to improve public educational programs toward cardiovascular risk factors and to enrich the endowment of pharmaceutical options and therapies to address CVDs, particularly for ischemic damage due to an impairment in the endothelial-myocardial relationship. Because ozone is a stimulator of the endothelial nitric oxide synthase/nitric oxide pathway, ozone therapy has been widely demonstrated to have the ability to counteract endothelial-cardiac disorders, providing a novel straightforward opportunity to reduce the impact of CVDs, including atrial fibrillation. In this review, we attempt to establish a state-of-the-art method for the use of ozone in CVD, suggesting that future remarks be addressed to provide fundamental insights into this issue. The purpose of this study was to highlight the role of ozone in the adjunctive medical treatment of cardiovascular pathologies such as acute myocardial infarction due to ischemic disorders.

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氧-臭氧疗法治疗心肌缺血中风和心血管疾病。
心血管疾病(CVDs)是全球人类健康的一大隐患。该领域的紧急事件包括主要涉及心血管疾病预防的大量研究。除了饮食习惯和生活方式外,医学知识也是改善心血管风险因素公共教育计划和丰富应对心血管疾病的药物选择和疗法所必需的,尤其是针对由于内皮与心肌关系受损而导致的缺血性损伤。由于臭氧是内皮一氧化氮合成酶/一氧化氮通路的刺激物,臭氧疗法已被广泛证明具有对抗内皮-心脏失调的能力,为减少心血管疾病(包括心房颤动)的影响提供了一个新的直接机会。在这篇综述中,我们试图为臭氧在心血管疾病中的应用建立一种最先进的方法,并建议今后的讨论要针对这一问题提供根本性的见解。本研究的目的是强调臭氧在心血管病变(如缺血性疾病导致的急性心肌梗塞)的辅助医疗中的作用。
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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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