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Retraction: Carbon monoxide inhibits Fas activating antibody-induced apoptosis in endothelial cells. 收缩:一氧化碳抑制Fas激活抗体诱导的内皮细胞凋亡。
IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-10-01 DOI: 10.4103/2045-9912.374045

[This corrects the article DOI: 10.1186/2045-9912-1-8].

[这更正了文章DOI:10.1186/2045-912-1-8]。
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引用次数: 0
The overlooked benefits of hydrogen-producing bacteria. 产氢细菌被忽视的好处。
IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.344977
Yusuke Ichikawa, Haru Yamamoto, Shin-Ichi Hirano, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh

Intestinal bacteria can be classified into "beneficial bacteria" and "harmful bacteria." However, it is difficult to explain the mechanisms that make "beneficial bacteria" truly beneficial to human health. This issue can be addressed by focusing on hydrogen-producing bacteria in the intestines. Although it is widely known that molecular hydrogen can react with hydroxyl radicals, generated in the mitochondria, to protect cells from oxidative stress, the beneficial effects of hydrogen are not fully pervasive because it is not generally thought to be metabolized in vivo. In recent years, it has become clear that there is a close relationship between the amount of hydrogen produced by intestinal bacteria and various diseases, and this report discusses this relationship.

肠道细菌可分为“有益菌”和“有害菌”。然而,很难解释使“有益菌”真正有益于人类健康的机制。这个问题可以通过关注肠道中的产氢细菌来解决。虽然众所周知,氢分子可以与线粒体中产生的羟基自由基反应,以保护细胞免受氧化应激,但氢的有益作用并不完全普遍,因为通常认为它不会在体内代谢。近年来,人们发现肠道细菌产氢量与各种疾病之间存在密切关系,本报告对这种关系进行了探讨。
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引用次数: 3
Ozone for the treatment of temporomandibular joint disorders: a systematic review and meta-analysis. 臭氧治疗颞下颌关节疾病:系统回顾和荟萃分析。
IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.345174
Rafael Torres-Rosas, María Eugenia Marcela Castro-Gutiérrez, Luis Angel Flores-Mejía, Eduardo Ulises Torres-Rosas, Roberto Miguel Nieto-García, Liliana Argueta-Figueroa

Temporomandibular joint disorders (TMD) generate pain and difficulties for mouth opening affecting the patients' quality of life. Ozone is an emerging therapy that has been proposed as a potential treatment, due to that, the evidence about its efficacy should be reviewed. Therefore, this work aimed to conduct a comprehensive systematic review to address the efficacy of ozone therapy for the treatment of pain and limited mouth opening in patients with TMD. The design of the included studies was clinical trials and observational studies, whereas, a series of cases, in vivo, and in vitro studies were excluded. The search was performed in PubMed, ClinicalTrials, Web of Science, and Scopus. Gray literature was searched at Google Scholar. Relevant data of all included studies were recorded. The risk of bias (using RoB 2) and the quality (using Grading of Recommendations Assessment, Development, and Evaluation) assessments were carried out. Meta-analyses using random-effects models of pain and maximal mouth opening data were performed. This review included 8 studies with 404 participants suffering limited function and pain related to TMD. At the overall bias of the studies, 25% exhibited some concerns and 75% had high risk; and the quality of the studies was low. The analysis of the included studies suggests that ozone therapy can diminish pain and improve the maximal mouth opening in TMD patients. However, there is no conclusive evidence of ozone therapy as a superior treatment for TMD compared with occlusal splint and pharmacotherapy.

颞下颌关节疾病(Temporomandibular joint disorders, TMD)会引起患者的疼痛和开口困难,影响患者的生活质量。臭氧是一种新兴的治疗方法,已被提议作为一种潜在的治疗方法,因此,有关其有效性的证据应进行审查。因此,本研究旨在对臭氧疗法治疗TMD患者疼痛和开口受限的疗效进行全面的系统评价。纳入的研究设计为临床试验和观察性研究,然而,排除了一系列病例,体内和体外研究。检索在PubMed, ClinicalTrials, Web of Science和Scopus中进行。灰色文献在谷歌学术搜索。记录所有纳入研究的相关资料。进行偏倚风险(使用RoB 2)和质量(使用分级推荐评估、发展和评价)评估。采用随机效应模型对疼痛和最大张嘴数据进行meta分析。本综述包括8项研究,404名受试者患有与TMD相关的功能受限和疼痛。在研究的总体偏倚中,25%的人表现出一些担忧,75%的人有高风险;而且研究的质量很低。对纳入研究的分析表明,臭氧治疗可以减轻TMD患者的疼痛并改善最大开口。然而,与咬合夹板和药物治疗相比,没有确凿的证据表明臭氧治疗是TMD的优越治疗方法。
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引用次数: 2
Isobaric forms of ropivacaine vs. bupivacaine in lower abdominal surgeries: a hospital-based, prospective, comparative study. 罗哌卡因与布比卡因在下腹手术中的等比重:一项基于医院的前瞻性比较研究。
IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.359678
Pavitra Patil, Pavan Vithal Dhulkhed, Vithal K Dhulkhed

We aimed to assess whether ropivacaine (0.75%; 22.5 mg) can replace bupivacaine (0.5%; 15 mg) as a better intrathecal anesthetic in lower abdominal surgery. In this hospital-based, single-blind, randomized, prospective, comparative study, 100 patients of either sex, aged between 18 and 70 years, weighing 40-80 kg, with American Society of Anesthesiologists physical status 1 and 2, and undergoing lower abdominal surgery were randomly allocated into two groups to receive intrathecal isobaric bupivacaine 0.5% 3 mL (15 mg) or ropivacaine 0.75% 3 mL (22.5 mg). In the intraoperative period, the onset, efficacy, duration, and regression of sensory and motor blockade and the quality of anesthesia and hemodynamic effects were observed at regular intervals. The ropivacaine and bupivacaine groups were comparable for demographic parameters. The duration of onset of sensory and motor blocks was significantly shorter in the bupivacaine group (P < 0.01). In the ropivacaine group, a faster recovery from sensory block (P = 0.02) and higher segmental height [thoracic (T)10 and T8] were achieved (P < 0.01). Bradycardia and hypotension were insignificant in the ropivacaine group (P > 0.05). Isobaric ropivacaine is a better spinal anesthetic in lower abdominal surgeries as it provides faster recovery from sensory block and a higher level of segmental sensory block with fewer side-effects.

我们的目的是评估罗哌卡因(0.75%;22.5 mg)可以代替布比卡因(0.5%;15 mg)作为一种较好的下腹部手术鞘内麻醉剂。在这项以医院为基础的单盲、随机、前瞻性、比较研究中,100名年龄在18至70岁之间、体重40-80公斤、美国麻醉师学会物理状态为1和2、接受下腹部手术的患者被随机分为两组,分别接受鞘内等压布比卡因0.5% 3 mL (15 mg)或罗哌卡因0.75% 3 mL (22.5 mg)。术中定期观察感觉和运动阻滞的发生、疗效、持续时间、消退情况以及麻醉质量和血流动力学效果。罗哌卡因组和布比卡因组人口学参数具有可比性。布比卡因组感觉阻滞和运动阻滞发生时间明显缩短(P < 0.01)。罗哌卡因组感觉阻滞恢复较快(P = 0.02),节段高度[胸(T)10和T8]较高(P < 0.01)。罗哌卡因组患者心动过缓、低血压差异无统计学意义(P > 0.05)。等压罗哌卡因是一种较好的下腹部手术脊髓麻醉剂,因为它能更快地从感觉阻滞中恢复,并能提高节段性感觉阻滞的水平,而且副作用更少。
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引用次数: 0
A randomized controlled study to compare analgesic efficacy of sublingual buprenorphine and intravenous tramadol in patients undergoing mastectomy. 一项随机对照研究,比较舌下含服丁丙诺啡和静脉注射曲马多对乳房切除术患者的镇痛效果。
IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.345170
Krishna Sumanth Dokku, Abhijit Sukumaran Nair, Srinivasa Shyam Prasad Mantha, Vibhavari Milind Naik, Mohammed Salman Saifuddin, Basanth Kumar Rayani

Sublingual (SL) buprenorphine is approved for managing acute postoperative pain, characterized by easy administration, good pain relief and good patient compliance. We hypothesized that SL buprenorphine would be a better perioperative analgesic compared to intravenous (IV) opioids like tramadol in patients undergoing mastectomy surgery for breast cancer. After institutional ethics committee approval, we randomized 60 patients with breast cancer into 2 groups. In buprenorphine group, patients received 200 μg of SL buprenorphine thrice daily and in tramadol group patients received 100 mg of IV tramadol thrice daily. The analgesic efficacy of SL buprenorphine was comparable to that of IV tramadol. Visual Analogue Scale scores had no significant difference between the two groups at various time frames (0, 1, 3, 6, 12, 18 and 24 hours) at rest and movement except at 0 and 3 hours during movement when the score was lower in the tramadol group than the buprenorphine group. Four patients in the buprenorphine group received rescue analgesic (IV morphine 3 mg). Analgesic efficacy of SL buprenorphine appears comparable to IV tramadol for managing postoperative pain after mastectomy. SL buprenorphine can be administered sublingually, which is an advantage.

舌下含服(SL)丁丙诺啡已被批准用于治疗急性术后疼痛,其特点是用药方便、镇痛效果好、患者依从性好。我们假设,与静脉注射阿片类药物(如曲马多)相比,舌下含服丁丙诺啡是乳腺癌乳房切除术患者围手术期更好的镇痛药。经机构伦理委员会批准后,我们将 60 名乳腺癌患者随机分为两组。在丁丙诺啡组,患者接受每天三次、每次 200 微克的丁丙诺啡静脉注射;在曲马多组,患者接受每天三次、每次 100 毫克的曲马多静脉注射。静脉注射丁丙诺啡的镇痛效果与静脉注射曲马多相当。两组患者在休息和运动的不同时间段(0、1、3、6、12、18 和 24 小时)的视觉模拟量表评分没有明显差异,只有在运动的 0 和 3 小时,曲马多组的评分低于丁丙诺啡组。丁丙诺啡组的四名患者接受了抢救性镇痛(静脉注射吗啡 3 毫克)。在控制乳房切除术后疼痛方面,可吸入丁丙诺啡的镇痛效果似乎与静脉注射曲马多相当。可吸入丁丙诺啡可以舌下给药,这是一个优点。
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引用次数: 0
Effectiveness of ozonized saline solution in the treatment of Proteus spp. bacterial cystitis. 臭氧化盐水治疗变形杆菌细菌性膀胱炎的疗效观察。
IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.350861
Ana Martiele Engelmann, Andressa Bueno, Nathalia Viana Barbosa, Carolina Machado, Diego Correa, Juliana Felipetto Cargnelutti, Cinthia Melazzo de Andrade

Bacterial cystitis is a common clinical problem among cats and dogs and is one of the main reasons for the administration of antimicrobials. This can cause serious damage to public and animal health, as this practice facilitates the selection of bacteria that are multidrug-resistant to antibiotics. In this context, it is urgent to understand and validate therapeutic modalities that complement antimicrobial treatment in cystitis cases. Ozone therapy has been proposed by scientists owing to the various mechanisms of action in a range of pathologies, both in human and animal medicine. This paper describes the bactericidal action of two different protocols of bladder irrigation with ozonized saline solution (59 μg/mL) in a paraplegic canine with recurrent bacterial cystitis caused by Proteus spp. In the first protocol, the bladder instillations were applied once a day for three consecutive days while in the second, successive lavages were performed throughout the day until a significant reduction in the presence of bacteria in the urine sediment. In this study, we were able to demonstrate that repeated bladder instillation within 24 hours was the most effective treatment for Proteus compared to a single instillation on successive days.

细菌性膀胱炎是猫和狗常见的临床问题,也是使用抗菌剂的主要原因之一。这可能对公众和动物健康造成严重损害,因为这种做法有利于选择对抗生素具有多重耐药性的细菌。在这种情况下,迫切需要了解和验证在膀胱炎病例中补充抗菌治疗的治疗方式。由于臭氧疗法在人类和动物医学的一系列病理中具有不同的作用机制,科学家们提出了臭氧疗法。本文描述了两种不同方案的臭氧盐水(59 μg/mL)膀胱冲洗对变形杆菌引起的复发性细菌性膀胱炎的截瘫犬的杀菌作用。在第一种方案中,膀胱灌注连续三天,每天一次,而在第二种方案中,连续全天进行灌洗,直到尿液沉积物中细菌的存在显著减少。在这项研究中,我们能够证明,与连续几天的单次输注相比,24小时内反复膀胱输注是治疗Proteus最有效的方法。
{"title":"Effectiveness of ozonized saline solution in the treatment of <i>Proteus</i> spp. bacterial cystitis.","authors":"Ana Martiele Engelmann,&nbsp;Andressa Bueno,&nbsp;Nathalia Viana Barbosa,&nbsp;Carolina Machado,&nbsp;Diego Correa,&nbsp;Juliana Felipetto Cargnelutti,&nbsp;Cinthia Melazzo de Andrade","doi":"10.4103/2045-9912.350861","DOIUrl":"https://doi.org/10.4103/2045-9912.350861","url":null,"abstract":"<p><p>Bacterial cystitis is a common clinical problem among cats and dogs and is one of the main reasons for the administration of antimicrobials. This can cause serious damage to public and animal health, as this practice facilitates the selection of bacteria that are multidrug-resistant to antibiotics. In this context, it is urgent to understand and validate therapeutic modalities that complement antimicrobial treatment in cystitis cases. Ozone therapy has been proposed by scientists owing to the various mechanisms of action in a range of pathologies, both in human and animal medicine. This paper describes the bactericidal action of two different protocols of bladder irrigation with ozonized saline solution (59 μg/mL) in a paraplegic canine with recurrent bacterial cystitis caused by Proteus spp. In the first protocol, the bladder instillations were applied once a day for three consecutive days while in the second, successive lavages were performed throughout the day until a significant reduction in the presence of bacteria in the urine sediment. In this study, we were able to demonstrate that repeated bladder instillation within 24 hours was the most effective treatment for Proteus compared to a single instillation on successive days.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"13 3","pages":"155-158"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/1c/MGR-13-155.PMC9979206.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10825633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A major leak from the condenser assembly of the anesthesia workstation. 麻醉工作站冷凝器组件严重泄漏。
IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.345173
Amit Rai, Krithika Ramamoorthy, Sachin Kulkarni, Sameer Taneja
Dear Editor, From a simple pneumatic device of the early 20th century, the anesthesia machine has evolved to incorporate various mechanical, electrical and electronic components to be more appropriately called anesthesia workstation.1 Despite advanced technology, a remote but life-threatening possibility of intraoperative machine malfunction exists. The leakage in the anesthesia circuit may result in hypoventilation, hypoxia, awareness, pollution of operating room and ventilatory failure even leading to death.2 Various causes of leaks in the breathing system have been reported in the literature that includes failure of an adjustable pressure limiting valve to close, mis-installation of a canister,3 weak connections in between different parts of the breathing circuit. We reported a case of gas leak from an unconventional site in the Datex Ohmeda Aespire View (GE Healthcare Pvt. Ltd. (India), Bangalore, India) workstation after anesthesia machine checks. As a routine, the complete pre-use anesthesia machine check was performed through the electronic self-check. A complete pre-use check of the machine included cylinders, pipelines, low-pressure system, vaporizers, breathing circuits, monitors and integrated ventilator. The circle system was also checked for any leaks and the ventilator systems were checked by setting the oxygen flow meter at minimum flows. However, after preliminary checks, soda lime in the carbon dioxide (CO2) absorber canister was changed. The canister was then reattached firmly. The water trap was also drained at this time. The patient was induced with propofol but bag mask ventilation was not adequate. There was a chest rise along with an end tidal CO2 trace but the reservoir bag was not filled adequately at a usual flow of 5 L/min. An oropharyngeal airway was inserted, and the flow increased to 10 L/min and the bag was filled better. The trachea was intubated with an 8.5 mm internal diameter cuffed endotracheal polyvinyl chloride tube using succinylcholine. However, the bag still required higher flows to fill up and when turned to the ventilation mode, the bellows required more than 8 L/min to fill up. We checked all the connections in the external circuit but found no loose connections or leaks. However, there was a large audible leak heard from the soda lime canister assembly. The CO2 absorber canister was removed and put back again to ensure that it is secured appropriately and locked. However, the audible leak still persisted. We decided to go ahead with the surgery as it was an emergency and ventilate the patient manually using Bains circuit. After the surgery got over, a detailed inspection of the CO2 canister assembly was done, and the leak seemed to originate from the EZchange and condenser part of the machine (Figure 1). Further evaluation revealed no issue in the EZchange part. The drain button of the condenser, however, was stuck in a semiopen position due to a soda lime granule trapped under the flap valve, leading
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引用次数: 0
Efficacy of ketamine, propofol, and dexmedetomidine for anesthesia in electroconvulsive therapy in treatment-resistant major depressive disorder patients: a double-blind randomized clinical trial. 氯胺酮、异丙酚和右美托咪定对耐药重度抑郁症患者电休克疗法的麻醉效果:一项双盲随机临床试验。
IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.350860
Hesameddin Modir, Behnam Mahmoodiyeh, Mehran Shayganfard, Ayda Abdus, Amir Almasi-Hashiani

Electroconvulsive therapy (ECT) is one of the therapeutic opportunities for patients with psychological disorders when they may decline to take medication. We sought to systematically compare the anesthetic efficacy of ketamine, propofol, and dexmedetomidine for electroconvulsive therapy in treatment-resistant major depressive disorder patients. This double-blind trial enrolled treatment-resistant major depressive disorder patients (n = 85) who had been hospitalized for ECT in the Amir Kabir Hospital's psychiatric ward (Arak, Iran). The ketamine, propofol, and dexmedetomidine groups received a dose of 0.2 μg/kg ketamine, 1.5 mg/kg propofol, and 0.8 mg/kg dexmedetomidine, respectively. In all intervention groups, 10 mL of interventional drugs was injected intravenously for 10 minutes, and in the placebo group, 10 mL of normal saline was given over the same period. The dexmedetomidine group's blood pressure was revealed comparatively lower at all times. Dexmedetomidine-treated patients showed their marked satisfaction, while those treated with propofol had shorter recovery time, shorter seizure duration, and shorter time to achieve an Aldrete score of 9-10 and increased relaxation, and next dexmedetomidine produced deeper relaxation. Propofol could shorten recovery time and seizure duration, and enhance relaxation, while dexmedetomidine was associated with higher patient satisfaction. Considering that any anesthetic which does not shorten seizure duration may serve efficiently for ECT and that ketamine-treated patients had more prolonged seizure duration, the preferred drug can hence be considered from various angles, thereby offering anesthetic agents with highly favorable efficacy in treatment-resistant major depressive disorder patients needing ECT. The drug choice thus depends on physical conditions, underlying diseases, and psychiatrist consultation.

电休克疗法(ECT)是心理障碍患者在拒绝服药时的治疗机会之一。我们试图系统地比较氯胺酮、异丙酚和右美托咪定对耐药重度抑郁症患者电休克疗法的麻醉效果。这项双盲试验招募了曾在阿米尔-卡比尔医院(伊朗阿拉克)精神科病房住院接受电休克治疗的重度抑郁障碍耐药患者(n = 85)。氯胺酮组、异丙酚组和右美托咪定组分别使用 0.2 μg/kg 氯胺酮、1.5 mg/kg 异丙酚和 0.8 mg/kg 右美托咪定。所有干预组均在 10 分钟内静脉注射 10 毫升干预药物,安慰剂组则在同一时间内注射 10 毫升生理盐水。结果显示,右美托咪定组的血压在任何时候都相对较低。右美托咪定治疗的患者表现出明显的满意度,而使用异丙酚治疗的患者恢复时间更短,发作持续时间更短,达到 Aldrete 评分 9-10 分的时间更短,放松程度更高,接下来右美托咪定产生的放松程度更深。丙泊酚可缩短恢复时间和癫痫发作持续时间,并增强松弛度,而右美托咪定可提高患者满意度。考虑到任何不会缩短发作持续时间的麻醉剂都可以有效地用于电痉挛疗法,而氯胺酮治疗的患者发作持续时间更长,因此可以从多个角度考虑首选药物,从而为需要电痉挛疗法的耐药重度抑郁症患者提供疗效更佳的麻醉剂。因此,药物的选择取决于身体状况、潜在疾病和精神科医生的咨询。
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引用次数: 0
Hydrogen applications: advances in the field of medical therapy. 氢的应用:医学治疗领域的进展。
IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.344978
Tao Yuan, Jian-Ning Zhao, Ni-Rong Bao

Hydrogen (H2) has been widely used in the chemical industry as a reducing agent. As the researches move along, increasing attention has been paid to its biological functions. The selective antioxidant effect of hydrogen is considered to be the main reason for medical applications. So far, many studies have confirmed its potential protective effects on ischemia/reperfusion injury of multiple organs, neurodegenerative diseases, bone and joint diseases, and respiratory diseases, opening a new era in the medical research and application of H2. Increasing studies have focused on its biological effects and molecular mechanisms in the treatment of different diseases. In this paper, we review the biological effects, molecular mechanisms and methods of H2 supply. We do hope that the advances in materials science can be better translated into medical applications and solve clinical problems. The medical application of H2 is promising, and how to prepare an H2 sustained-release system to achieve a sustained and stable H2 supply in the body and ultimately improve the therapeutic effect of H2 is a problem worthy of further investigation.

氢(H2)作为还原剂在化学工业中得到了广泛的应用。随着研究的深入,其生物学功能越来越受到人们的关注。氢的选择性抗氧化作用被认为是其在医学上应用的主要原因。迄今为止,许多研究证实了其对多器官缺血再灌注损伤、神经退行性疾病、骨关节疾病、呼吸系统疾病的潜在保护作用,开启了H2的医学研究和应用的新时代。越来越多的研究集中在其治疗不同疾病的生物学效应和分子机制上。本文就植物供氢的生物学效应、分子机制和方法作一综述。我们希望材料科学的进步能够更好地转化为医学应用,解决临床问题。H2的医学应用前景广阔,如何制备H2缓释体系,实现体内持续稳定的H2供应,最终提高H2的治疗效果是一个值得进一步研究的问题。
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引用次数: 2
Molecular hydrogen therapy for neurological diseases: a review of current evidence. 神经系统疾病的分子氢疗法:当前证据综述。
IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.359677
Dinesh Ramanathan, Lei Huang, Taylor Wilson, Warren Boling

Reactive oxygen species and other free radicals cause oxidative stress which is the underlying pathogenesis of cellular injury in various neurological diseases. Molecular hydrogen therapy with its unique biological property of selectively scavenging pathological free radicals has demonstrated therapeutic potential in innumerable animal studies and some clinical trials. These studies have implicated several cellular pathways affected by hydrogen therapy in explaining its anti-inflammatory and antioxidative effects. This article reviews relevant animal and clinical studies that demonstrate neuroprotective effects of hydrogen therapy in stroke, neurodegenerative diseases, neurotrauma, and global brain injury.

活性氧等自由基引起的氧化应激是多种神经系统疾病中细胞损伤的潜在发病机制。分子氢疗法以其独特的选择性清除病理自由基的生物学特性,在无数的动物研究和一些临床试验中显示出治疗潜力。这些研究暗示了氢疗法影响的几种细胞途径,以解释其抗炎和抗氧化作用。本文综述了氢疗法在脑卒中、神经退行性疾病、神经创伤和全脑损伤中的神经保护作用的相关动物和临床研究。
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引用次数: 3
期刊
Medical Gas Research
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