Optimization of Parameters for Atom Probe Tomography Analysis of β-Tricalcium Phosphates.

IF 2.9 4区工程技术 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Microscopy and Microanalysis Pub Date : 2025-02-03 DOI:10.1093/mam/ozae077

Selase Torkornoo, Marc Bohner, Ingrid McCarroll, Baptiste Gault

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Abstract

The biocompatibility and resorption characteristics of β-tricalcium phosphate (β-TCP, Ca3(PO4)2) have made it a coveted alternative for bone grafts. However, the underlying mechanisms governing the biological interactions between β-tricalcium phosphate and osteoclasts remain elusive. It has been speculated that the composition at grain boundaries might vary and affect β-TCP resorption properties. Atom probe tomography (APT) offers a quantitative approach to assess the composition of the grain boundaries, and thus advance our comprehension of the biological responses within the microstructure and chemical composition at the nanoscale. The precise quantitative analysis of chemical composition remains a notable challenge in APT, primarily due to the influence of measurement conditions on compositional accuracy. In this study, we investigated the impact of laser pulse energy on the composition of β-TCP using APT, aiming for the most precise Ca:P ratio and consistent results across multiple analyses performed with different sets of analysis conditions and on two different instruments.

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β-磷酸三钙原子探针断层扫描分析参数的优化。

β-磷酸三钙（β-TCP，Ca3(PO4)2）的生物相容性和吸收特性使其成为令人垂涎的骨移植替代品。然而，β-磷酸三钙与破骨细胞之间的生物相互作用的基本机制仍然难以捉摸。据推测，晶界处的成分可能会发生变化，并影响 β-TCP 的吸收特性。原子探针断层扫描（APT）提供了一种定量评估晶界成分的方法，从而促进了我们对微观结构和纳米尺度化学成分中生物反应的理解。对化学成分的精确定量分析仍然是 APT 的一个显著挑战，这主要是由于测量条件对成分精度的影响。在本研究中，我们利用 APT 研究了激光脉冲能量对 β-TCP 成分的影响，目的是获得最精确的 Ca:P 比率，并在两台不同仪器上使用不同的分析条件进行多次分析时获得一致的结果。

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来源期刊

Microscopy and Microanalysis 工程技术-材料科学：综合

CiteScore

1.10

自引率

10.70%

发文量

1391

审稿时长

6 months

期刊介绍： Microscopy and Microanalysis publishes original research papers in the fields of microscopy, imaging, and compositional analysis. This distinguished international forum is intended for microscopists in both biology and materials science. The journal provides significant articles that describe new and existing techniques and instrumentation, as well as the applications of these to the imaging and analysis of microstructure. Microscopy and Microanalysis also includes review articles, letters to the editor, and book reviews.