Degradation of andrographolide in Andrographis paniculata over 1 year storage.

IF 3 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS Phytochemical Analysis Pub Date : 2024-08-28 DOI:10.1002/pca.3441

Md Tanvin Ahammed, Md Zakir Sultan, Md Sabbir Hossain, Mamun Al Mahtab, Sitesh Chandra Bachar

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Abstract

Introduction: Andrographolide is a bioactive component found in the medicinal herb Andrographis paniculata (Burm. f.) Wall. ex Nees (Family-Acanthaceae) is well-known for its ability to cure liver disorders and as a bitter tonic.

Objective: In this study, the rate of degradation of andrographolide was examined over the course of a year of storage.

Materials and methods: New and old (1-year storage) A. paniculata powder samples were used in the study. High-performance liquid chromatography (HPLC) was used to assess the concentration of andrographolide after its extraction using ethanol as the solvent.

Results: The findings demonstrated a 69.26% progressive deterioration of andrographolide over the storage period. Temperature and crystallinity are two factors that affect how quickly andrographolide degrades.

Conclusion: The results emphasize how crucial it is to retain the effectiveness of A. paniculata extract by avoiding prolonged storage or by providing ideal storage conditions.

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穿心莲中的穿心莲内酯在储存一年后的降解情况。

简介：穿心莲内酯是一种生物活性成分，存在于穿心莲（穿心莲科）药草穿心莲（Burm：本研究对穿心莲内酯在一年储存过程中的降解率进行了检测：研究使用了新旧（储存 1 年）穿心莲内酯粉末样品。以乙醇为溶剂提取穿心莲内酯后，使用高效液相色谱法（HPLC）评估穿心莲内酯的浓度：研究结果表明，穿心莲内酯在贮藏期间会逐渐变质 69.26%。温度和结晶度是影响穿心莲内酯降解速度的两个因素：结果强调了通过避免长时间储存或提供理想的储存条件来保持穿心莲内酯提取物功效的重要性。

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来源期刊

Phytochemical Analysis 生物-分析化学

CiteScore

6.00

自引率

6.10%

发文量

审稿时长

1.7 months

期刊介绍： Phytochemical Analysis is devoted to the publication of original articles concerning the development, improvement, validation and/or extension of application of analytical methodology in the plant sciences. The spectrum of coverage is broad, encompassing methods and techniques relevant to the detection (including bio-screening), extraction, separation, purification, identification and quantification of compounds in plant biochemistry, plant cellular and molecular biology, plant biotechnology, the food sciences, agriculture and horticulture. The Journal publishes papers describing significant novelty in the analysis of whole plants (including algae), plant cells, tissues and organs, plant-derived extracts and plant products (including those which have been partially or completely refined for use in the food, agrochemical, pharmaceutical and related industries). All forms of physical, chemical, biochemical, spectroscopic, radiometric, electrometric, chromatographic, metabolomic and chemometric investigations of plant products (monomeric species as well as polymeric molecules such as nucleic acids, proteins, lipids and carbohydrates) are included within the remit of the Journal. Papers dealing with novel methods relating to areas such as data handling/ data mining in plant sciences will also be welcomed.