Bacillus lipopeptides as key players in rhizosphere chemical ecology.

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Microbiology Pub Date : 2024-08-29 DOI:10.1016/j.tim.2024.08.001
Guillaume Balleux, Monica Höfte, Anthony Arguelles-Arias, Magali Deleu, Marc Ongena
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Abstract

Microbial natural products are widely explored for their therapeutic potential. Understanding the underlying evolutionary and adaptive forces driving their production remains a fundamental question in biology. Amphiphilic cyclic lipopeptides (CLPs), a prominent category of bacterial specialized metabolites, show strong antimicrobial activity, particularly against phytopathogens. It is thus assumed that these compounds are deployed by soil- or rhizosphere-dwelling bacteria as microbial weapons in competitive natural environments. Here, we challenge this reductionist perspective and present evidence that Bacillus CLPs are prominent chemical mediators of ecological interactions. They help Bacillus to communicate, compete, defend against predators, or cooperate and establish mutualistic relationships with other (micro)organisms. Additional parallel examples are highlighted in other genera, such as Pseudomonas. This broader perspective underscores the need for further investigation into the role of CLPs in shaping the adaptive strategies of key rhizobacterial species.

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芽孢杆菌脂肽是根圈化学生态学中的关键角色。
微生物天然产物因其治疗潜力而被广泛开发。了解驱动其产生的基本进化和适应力仍然是生物学的一个基本问题。两亲环脂肽(CLPs)是细菌特化代谢产物的一个重要类别,具有很强的抗菌活性,特别是对植物病原体。因此,人们认为这些化合物是生活在土壤或根圈的细菌在竞争激烈的自然环境中作为微生物武器使用的。在此,我们对这种还原论观点提出质疑,并提出证据证明芽孢杆菌的 CLPs 是生态相互作用的重要化学媒介。它们帮助芽孢杆菌与其他(微)生物进行交流、竞争、抵御天敌或合作并建立互惠关系。其他菌属如假单胞菌中也有类似的例子。这种更广阔的视角强调了进一步研究 CLPs 在塑造关键根瘤菌物种适应策略中的作用的必要性。
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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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