Advances in lasso peptide discovery, biosynthesis, and function.

IF 13.6 2区 生物学 Q1 GENETICS & HEREDITY Trends in Genetics Pub Date : 2024-11-01 Epub Date: 2024-08-31 DOI:10.1016/j.tig.2024.08.002
Susanna E Barrett, Douglas A Mitchell
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Abstract

Lasso peptides are a large and sequence-diverse class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products characterized by their slip knot-like shape. These unique, highly stable peptides are produced by bacteria for various purposes. Their stability and sequence diversity make them a potentially useful scaffold for biomedically relevant folded peptides. However, many questions remain about lasso peptide biosynthesis, ecological function, and diversification potential for biomedical and agricultural applications. This review discusses new insights and open questions about lasso peptide biosynthesis and biological function. The role that genome mining has played in the development of new methodologies for discovering and diversifying lasso peptides is also discussed.

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套索肽的发现、生物合成和功能方面的进展。
拉索肽是一大类序列多样的核糖体合成和翻译后修饰肽(RiPP)天然产物,其特点是具有滑结般的形状。这些独特、高度稳定的肽由细菌生产,用于各种用途。它们的稳定性和序列多样性使其有可能成为生物医学相关折叠肽的有用支架。然而,关于拉索肽的生物合成、生态功能以及在生物医学和农业应用中的多样化潜力,仍然存在许多问题。本综述将讨论有关套索肽生物合成和生物功能的新见解和未决问题。还讨论了基因组挖掘在开发发现拉索肽并使其多样化的新方法中发挥的作用。
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来源期刊
Trends in Genetics
Trends in Genetics 生物-遗传学
CiteScore
20.90
自引率
0.90%
发文量
160
审稿时长
6-12 weeks
期刊介绍: Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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