Impact of the Combination of Anamorelin and Rehabilitation on Functional and Nutritional Outcomes in Patients with Cancer Cachexia.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS Nutrition and Cancer-An International Journal Pub Date : 2024-08-29 DOI:10.1080/01635581.2024.2397060
Makoto Hasegawa, Yohei Sanmoto, Koji Kono
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Abstract

Cancer cachexia, characterized by the progressive loss of skeletal muscle mass, leads to functional impairment and poor prognosis. Anamorelin is approved for treating cancer cachexia in Japan; however, the factors influencing its discontinuation and the impact of combining anamorelin with rehabilitation remain unclear. Therefore, we retrospectively analyzed 82 patients with cancer cachexia to identify factors associated with anamorelin discontinuation and assess changes in nutritional status and motor function using non-dominant handgrip strength after 12 wk. Patients received outpatient rehabilitation, combining resistance and aerobic training every two weeks, alongside anamorelin therapy. Our findings indicate that patients with an ECOG performance status of 1 or 2 were less likely to continue anamorelin therapy for 12 wk compared to those with a performance status of 0 (odds ratio 2.71; 95% CI 1.05 - 7.00; p = 0.040). Significant improvements were observed in body weight (48.8 to 53.7 kg, p < 0.001), skeletal muscle mass (6.4 to 6.9 kg/m2, p < 0.001), FAACT score (11.5 to 18.0, p < 0.001), and non-dominant handgrip strength (20.5 to 21.7 kg, p = 0.018) after 12 wk. Early initiation of anamorelin with regular rehabilitation is recommended to enhance nutritional status and motor function in patients with cancer cachexia.

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阿那莫林与康复治疗相结合对癌症患者功能和营养结果的影响
癌症恶病质的特点是骨骼肌质量逐渐丧失,会导致功能障碍和预后不良。在日本,阿那莫瑞林被批准用于治疗癌症恶病质;然而,影响阿那莫瑞林停药的因素以及将阿那莫瑞林与康复治疗相结合的影响仍不清楚。因此,我们对 82 名癌症恶病质患者进行了回顾性分析,以确定与停用阿莫瑞林相关的因素,并评估 12 周后营养状况和非惯用手握力运动功能的变化。患者在接受阿莫瑞林治疗的同时,还接受了门诊康复治疗,每两周进行一次阻力训练和有氧训练。我们的研究结果表明,与 ECOG 表现为 0 的患者相比,ECOG 表现为 1 或 2 的患者继续接受阿莫瑞林治疗 12 周的可能性较低(几率比 2.71;95% CI 1.05 - 7.00;P = 0.040)。12 周后,体重明显改善(48.8 至 53.7 千克,P 2,P = 0.018)。建议尽早开始使用阿那莫林并定期进行康复治疗,以改善癌症恶病质患者的营养状况和运动功能。
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来源期刊
CiteScore
5.80
自引率
3.40%
发文量
172
审稿时长
3 months
期刊介绍: This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.
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