Impact of the novel chlorinated polyfluorinated ether sulfonate, F-53B, on gill structure and reproductive toxicity in zebrafish

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY Aquatic Toxicology Pub Date : 2024-08-30 DOI:10.1016/j.aquatox.2024.107072

Xianfeng Wang , Yiman Zhao , Fang Li , Zelong Li , Junping Liang , Hui Li , Xiaoyu Zhang , Man Zhang

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Abstract

6:2 Chlorinated polyfluorinated ether sulfonate, commonly known as F-53B, is widely used as a mist suppressant in various industries and is frequently detected in the environment. Despite its prevalent presence, the adverse effects of F-53B are not well understood and require future investigation. This study utilized zebrafish embryos and adults to examine the toxic effects of F-53B. Our findings revealed that F-53B impaired gill structure and increased erythrocyte numbers in adult zebrafish. Notably, F-53B demonstrated a higher sensitivity for inducing mortality (LC₅₀ at 96 h) in adult zebrafish compared to embryos. Additionally, F-53B disrupted the expression of critical steroidogenic genes and hindered sex hormone production, which negatively affecting egg production. In conclusion, this study underscores the detrimental impact of F-53B on gill structure and reproductive toxicity in zebrafish, providing valuable insights into its overall toxicity.

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新型氯化多氟醚磺酸盐 F-53B 对斑马鱼鳃结构和生殖毒性的影响

6:2 氯化多氟醚磺酸盐，俗称 F-53B，在各行各业被广泛用作抑雾剂，并经常在环境中检测到。尽管 F-53B 广泛存在，但人们对其不良影响还不甚了解，需要在今后进行调查。本研究利用斑马鱼胚胎和成鱼来研究 F-53B 的毒性效应。我们的研究结果表明，F-53B 会损害成体斑马鱼的鳃结构并增加其红细胞数量。值得注意的是，与胚胎斑马鱼相比，F-53B 对诱导成年斑马鱼死亡（96 小时半数致死浓度）的敏感性更高。此外，F-53B 破坏了关键类固醇生成基因的表达，阻碍了性激素的产生，从而对卵子的生产产生了负面影响。总之，本研究强调了 F-53B 对斑马鱼鳃结构和生殖毒性的不利影响，为了解其整体毒性提供了宝贵的见解。

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来源期刊

Aquatic Toxicology 环境科学-毒理学

CiteScore

7.10

自引率

4.40%

发文量

250

审稿时长

56 days

期刊介绍： Aquatic Toxicology publishes significant contributions that increase the understanding of the impact of harmful substances (including natural and synthetic chemicals) on aquatic organisms and ecosystems. Aquatic Toxicology considers both laboratory and field studies with a focus on marine/ freshwater environments. We strive to attract high quality original scientific papers, critical reviews and expert opinion papers in the following areas: Effects of harmful substances on molecular, cellular, sub-organismal, organismal, population, community, and ecosystem level; Toxic Mechanisms; Genetic disturbances, transgenerational effects, behavioral and adaptive responses; Impacts of harmful substances on structure, function of and services provided by aquatic ecosystems; Mixture toxicity assessment; Statistical approaches to predict exposure to and hazards of contaminants The journal also considers manuscripts in other areas, such as the development of innovative concepts, approaches, and methodologies, which promote the wider application of toxicological datasets to the protection of aquatic environments and inform ecological risk assessments and decision making by relevant authorities.