The power and pitfalls of underpowered studies.

IF 2.9 3区 医学 Q2 PHARMACOLOGY & PHARMACY Pharmacotherapy Pub Date : 2024-09-01 Epub Date: 2024-09-03 DOI:10.1002/phar.4605
Ryan M Carnahan, Grant D Brown
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Abstract

This article reflects on the potential value and many pitfalls of underpowered studies to help authors and readers consider whether and how they contribute meaningfully to the published literature. A basic introduction to power and sample size calculations is provided. Several problems that can arise in analysis and publication of underpowered studies are described. In addition, features of underpowered studies that may provide value are proposed, including when the hypothesis test of interest is a limited part of the story, the data is rich enough to showcase interesting features of the population of interest, when the rarity or ubiquity of events is an important finding, and when the study is preregistered to reduce the impact of publication bias. Several reporting guidelines for underpowered studies are also suggested.

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动力不足研究的威力和陷阱。
本文对动力不足研究的潜在价值和许多陷阱进行了反思,以帮助作者和读者考虑这些研究是否以及如何对已发表的文献做出有意义的贡献。文章提供了关于研究动力和样本量计算的基本介绍。介绍了在分析和发表动力不足研究时可能出现的几个问题。此外,还提出了可能具有价值的动力不足研究的特点,包括当感兴趣的假设检验是研究的有限部分时、当数据丰富到足以展示感兴趣人群的有趣特征时、当事件的罕见性或普遍性是一项重要发现时,以及当研究经过预先登记以减少发表偏倚的影响时。此外,还提出了几条关于研究动力不足的报告指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmacotherapy
Pharmacotherapy 医学-药学
CiteScore
7.80
自引率
2.40%
发文量
93
审稿时长
4-8 weeks
期刊介绍: Pharmacotherapy is devoted to publication of original research articles on all aspects of human pharmacology and review articles on drugs and drug therapy. The Editors and Editorial Board invite original research reports on pharmacokinetic, bioavailability, and drug interaction studies, clinical trials, investigations of specific pharmacological properties of drugs, and related topics.
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